Tomoko Kobayashi Selected Research

Streptozocin (Streptozotocin)

12/2023	Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice.
1/2022	Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin.
12/2021	Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice.
9/2021	Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet.

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Tomoko Kobayashi Research Topics

Disease

16	Neoplasms (Cancer) 04/2024 - 07/2007
10	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2024 - 01/2021
7	Infections 04/2024 - 07/2006
5	Obesity 09/2021 - 11/2017
4	Type 2 Diabetes Mellitus (MODY) 12/2023 - 01/2020
4	Inflammation (Inflammations) 09/2022 - 03/2008
4	Seizures (Absence Seizure) 10/2020 - 04/2015
4	Anaphylaxis (Anaphylactic Shock) 01/2020 - 08/2015
4	Pain (Aches) 10/2015 - 08/2007
3	Carcinoma (Carcinomatosis) 04/2024 - 12/2023
3	Hypertension (High Blood Pressure) 02/2024 - 01/2021
3	Neurogenic Diabetes Insipidus (Central Diabetes Insipidus) 01/2024 - 10/2022
3	Hypothyroidism 01/2022 - 03/2018
3	Hyperglycemia 01/2022 - 01/2020
3	Thyroiditis 01/2022 - 03/2018
3	Body Weight (Weight, Body) 09/2021 - 04/2002
3	Brain Diseases (Brain Disorder) 01/2020 - 02/2017
3	Disease Progression 05/2019 - 10/2015
3	Hypersensitivity (Allergy) 01/2019 - 08/2015
3	Infantile Spasms (West Syndrome) 11/2016 - 04/2015
2	Headache (Headaches) 05/2024 - 01/2013
2	COVID-19 05/2024 - 04/2024
2	Thyrotoxicosis 04/2024 - 01/2021
2	Dyslipidemias (Dyslipidemia) 02/2024 - 09/2021
2	Pneumonia (Pneumonitis) 01/2024 - 07/2006
2	Neoplasm Metastasis (Metastasis) 12/2023 - 12/2023
2	Diabetes Insipidus 03/2023 - 10/2020
2	Pathologic Constriction (Stenosis) 02/2023 - 12/2007
2	Urinary Bladder Neoplasms (Bladder Cancer) 02/2023 - 08/2007
2	Abscess 01/2023 - 01/2010
2	Myocardial Infarction 01/2023 - 02/2021
2	Hypopituitarism (Sheehan's Syndrome) 01/2023 - 01/2021
2	Death (Near-Death Experience) 01/2023 - 02/2021
2	Latent Autoimmune Diabetes in Adults 01/2022 - 10/2021
2	Hyperalgesia 01/2022 - 03/2013
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2021 - 01/2020
2	Tuberous Sclerosis (Bourneville's Disease) 10/2020 - 11/2016
2	Prostatic Neoplasms (Prostate Cancer) 01/2018 - 02/2008
2	Spasm (Spasms) 04/2015 - 11/2013
2	Asthma (Bronchial Asthma) 03/2013 - 07/2005
2	Acute Coronary Syndrome 12/2009 - 01/2006
2	Ventricular Tachycardia 12/2009 - 01/2006
2	Ventricular Premature Complexes (Premature Ventricular Contraction) 12/2009 - 01/2006
2	Coronary Artery Disease (Coronary Atherosclerosis) 10/2004 - 09/2002
1	Vomiting 05/2024
1	Brain Neoplasms (Brain Tumor) 04/2024
1	Interstitial Lung Diseases (Interstitial Lung Disease) 02/2024
1	Skin Manifestations 02/2024
1	Malignant Mesothelioma 02/2024
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2024

Drug/Important Bio-Agent (IBA)

8	Glucose (Dextrose)FDA LinkGeneric 12/2023 - 12/2010
8	Insulin (Novolin)FDA Link 12/2023 - 01/2018
7	AntibodiesIBA 01/2022 - 11/2011
6	Immune Checkpoint InhibitorsIBA 01/2023 - 03/2018
5	Proteins (Proteins, Gene)FDA Link 01/2023 - 07/2006
4	Streptozocin (Streptozotocin)FDA Link 12/2023 - 09/2021
3	NivolumabIBA 02/2024 - 03/2018
3	SteroidsIBA 01/2024 - 05/2014
3	Arginine Vasopressin (Argipressin)IBA 03/2023 - 10/2020
3	Messenger RNA (mRNA)IBA 09/2022 - 07/2006
3	LeptinIBA 01/2022 - 01/2021
3	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 06/2006
3	CytokinesIBA 01/2020 - 03/2008
2	ORALIT (ORS)IBA 04/2024 - 05/2012
2	pembrolizumabIBA 04/2024 - 12/2023
2	Thyroxine (Levothyroxine)FDA LinkGeneric 04/2024 - 03/2018
2	Vasopressins (Vasopressin)IBA 01/2024 - 10/2022
2	ChemokinesIBA 12/2023 - 03/2008
2	Adrenal Cortex Hormones (Corticosteroids)IBA 03/2023 - 01/2013
2	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2022
2	omega-Chloroacetophenone (Mace)IBA 01/2023 - 02/2021
2	CholesterolIBA 01/2022 - 10/2004
2	RamucirumabIBA 01/2022 - 06/2020
2	B7-H1 AntigenIBA 01/2022 - 05/2021
2	Blood Glucose (Blood Sugar)IBA 09/2021 - 01/2020
2	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2020 - 04/2015
2	Vigabatrin FDA Link 11/2016 - 11/2013
2	Serotonin (5 Hydroxytryptamine)IBA 03/2014 - 09/2004
2	p38 Mitogen-Activated Protein KinasesIBA 03/2013 - 03/2008
2	JNK Mitogen-Activated Protein KinasesIBA 03/2008 - 07/2007
1	COVID-19 VaccinesIBA 05/2024
1	AntacidsIBA 04/2024
1	Proton Pump InhibitorsIBA 04/2024
1	Trimethoprim (Proloprim)FDA LinkGeneric 04/2024
1	Sulfamethoxazole FDA LinkGeneric 04/2024
1	TransferasesIBA 02/2024
1	SodiumIBA 02/2024
1	SaltsIBA 02/2024
1	PotassiumIBA 02/2024
1	oxidized low density lipoproteinIBA 02/2024
1	Mutant Proteins (Protein, Mutant)IBA 01/2024
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 12/2023

Therapy/Procedure

14	Therapeutics 04/2024 - 09/2003
4	Glycemic Control 12/2023 - 01/2020
3	Stents 10/2014 - 07/2003
2	Immunotherapy 12/2023 - 02/2023
2	Catheter Ablation 12/2009 - 01/2006
1	Craniotomy 04/2024
1	Metastasectomy 12/2023
1	Radiotherapy 12/2023