Christine Klein Selected Research

sapropterin (tetrahydrobiopterin)

1/2022	Relationship of Genotype, Phenotype, and Treatment in Dopa-Responsive Dystonia: MDSGene Review.
11/2011	Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease.

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Christine Klein Research Topics

Disease

93	Parkinson Disease (Parkinson's Disease) 03/2024 - 09/2005
30	Parkinsonian Disorders (Parkinsonism) 11/2023 - 04/2002
30	Dystonia (Limb Dystonia) 11/2022 - 08/2002
21	Movement Disorders (Movement Disorder) 01/2023 - 11/2002
12	X-Linked Torsion Dystonia 3 01/2023 - 09/2014
11	Mitochondrial Diseases (Mitochondrial Disease) 01/2023 - 07/2012
11	Myoclonic dystonia 01/2022 - 11/2002
9	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 09/2010
8	Dopa-responsive Dystonia 02/2024 - 01/2014
8	Inflammation (Inflammations) 10/2023 - 01/2018
8	Dystonia musculorum deformans type 1 09/2014 - 11/2002
6	Dyskinesias (Dyskinesia) 01/2017 - 11/2006
5	Atrophy 01/2023 - 11/2010
4	Chorea (Rheumatic Chorea) 02/2024 - 01/2016
4	Gaucher Disease (Gaucher's Disease) 09/2023 - 07/2010
4	Genetic Predisposition to Disease (Genetic Predisposition) 01/2021 - 12/2004
3	Disease Progression 01/2024 - 01/2017
3	Tremor (Tremors) 12/2023 - 08/2010
3	Cognitive Dysfunction 06/2021 - 11/2010
3	Task-Specific Focal Dystonia 04/2016 - 06/2014
3	Dystonic Disorders (Writer's Cramp) 02/2011 - 05/2010
2	Myoclonus (Nocturnal Myoclonus) 01/2022 - 08/2010
2	COVID-19 01/2022 - 06/2021
2	Infections 01/2022 - 06/2012
2	Bites and Stings (Sting) 10/2020 - 01/2018
2	Neoplasms (Cancer) 01/2020 - 11/2003
2	Neuroblastoma 01/2019 - 01/2017
2	Sialorrhea 01/2010 - 04/2004
1	Synucleinopathies 03/2024
1	Spinocerebellar Degenerations (Marinesco Sjogren Syndrome) 03/2024
1	Rare Diseases (Rare Disease) 02/2024
1	Proteostasis Deficiencies 12/2023
1	Dizziness (Lightheadedness) 12/2023
1	Epilepsy (Aura) 01/2023
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2023
1	Stroke (Strokes) 01/2023
1	Ischemia 11/2022
1	Necrosis 10/2022

Drug/Important Bio-Agent (IBA)

21	Proteins (Proteins, Gene)FDA Link 10/2023 - 04/2002
18	Phosphotransferases (Kinase)IBA 01/2023 - 09/2006
12	SynucleinsIBA 03/2024 - 04/2012
12	Leucine (L-Leucine)FDA Link 01/2021 - 09/2006
11	alpha-SynucleinIBA 03/2024 - 09/2005
10	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 05/2009
9	Levodopa (L Dopa)FDA LinkGeneric 02/2024 - 09/2005
9	Sarcoglycans (beta Sarcoglycan)IBA 10/2017 - 11/2002
8	Glucosylceramidase (Glucocerebrosidase)IBA 09/2023 - 07/2010
8	Retroelements (Retrotransposon)IBA 01/2023 - 01/2018
8	Biomarkers (Surrogate Marker)IBA 01/2023 - 08/2007
7	IronIBA 01/2023 - 09/2010
7	Mitochondrial DNA (mtDNA)IBA 01/2023 - 01/2018
6	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 04/2007
5	EnzymesIBA 01/2020 - 04/2002
5	PTEN-induced putative kinaseIBA 01/2017 - 06/2006
4	Botulinum Toxins (Botulinum Toxin)IBA 10/2013 - 04/2004
4	Adenosine Triphosphatases (ATPase)IBA 09/2012 - 08/2007
4	Antipsychotic Agents (Antipsychotics)IBA 04/2011 - 04/2004
3	UbiquitinIBA 12/2023 - 11/2018
3	RNA (Ribonucleic Acid)IBA 11/2022 - 01/2020
3	CytokinesIBA 10/2022 - 01/2018
3	Interleukin-6 (Interleukin 6)IBA 10/2022 - 01/2018
3	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2022 - 01/2020
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2022 - 08/2010
3	AntibodiesIBA 01/2022 - 11/2003
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 10/2010
3	NucleotidesIBA 12/2020 - 09/2014
3	Messenger RNA (mRNA)IBA 01/2017 - 02/2015
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2014 - 11/2007
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/2023 - 08/2022
2	Adenosine Monophosphate (AMP)IBA 10/2023 - 01/2018
2	CeramidesIBA 01/2023 - 10/2021
2	TubulinIBA 11/2022 - 04/2013
2	C-Reactive ProteinIBA 10/2022 - 10/2020
2	Nonsense Codon (Nonsense Mutation)IBA 01/2022 - 02/2016
2	sapropterin (tetrahydrobiopterin)FDA Link 01/2022 - 11/2011
2	InterferonsIBA 01/2021 - 10/2020
2	Prokaryotic Initiation Factor-2IBA 01/2021 - 01/2021
2	hydrogen sulfite (bisulfite)IBA 12/2020 - 10/2008
2	LipidsIBA 01/2018 - 01/2017
2	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 12/2017 - 01/2014
2	Caffeine (No Doz)FDA LinkGeneric 04/2017 - 11/2006
2	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2017 - 01/2016
2	UbiquinoneIBA 01/2017 - 07/2012
2	Guanosine Triphosphate (GTP)IBA 08/2012 - 12/2011
2	P-type ATPasesIBA 06/2012 - 02/2009
2	rimabotulinumtoxinB FDA Link 01/2010 - 08/2002
2	Clozapine (Clozaril)FDA LinkGeneric 01/2010 - 04/2004
2	Dihydroxyphenylalanine (Dopa)IBA 08/2002 - 07/2002
1	fibroblast growth factor 14IBA 03/2024
1	Replication Protein C (Replication Factor C)IBA 03/2024
1	Glucose (Dextrose)FDA LinkGeneric 01/2023
1	tributyl phosphate (TBP)IBA 01/2023
1	SphingolipidsIBA 01/2023
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 10/2022

Therapy/Procedure

20	Therapeutics 02/2024 - 07/2010
6	Deep Brain Stimulation 01/2019 - 08/2002
5	Precision Medicine 01/2024 - 01/2020
2	Activities of Daily Living (ADL) 01/2022 - 01/2019
2	Transcranial Magnetic Stimulation 04/2016 - 10/2015
2	Injections 01/2010 - 04/2004