Takashi Kijima Selected Research

Proteins (Proteins, Gene)

10/2019	Esophageal 3D organoids of MPV17-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition.
12/2018	Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells.
1/2017	Classification of idiopathic interstitial pneumonias using anti-myxovirus resistance-protein 1 autoantibody.
7/2012	Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity.
10/2006	Overexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation.
10/2006	Absence of CD9 enhances adhesion-dependent morphologic differentiation, survival, and matrix metalloproteinase-2 production in small cell lung cancer cells.
8/2005	Propionibacterium acnes-induced hepatic granuloma formation is impaired in mice lacking tetraspanin CD9.
2/2002	Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition.

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Takashi Kijima Research Topics

Disease

57	Neoplasms (Cancer) 02/2024 - 02/2002
39	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2024 - 09/2004
20	Malignant Mesothelioma 03/2023 - 09/2006
17	Lung Neoplasms (Lung Cancer) 01/2021 - 02/2002
15	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 02/2024 - 02/2002
14	Neoplasm Metastasis (Metastasis) 11/2023 - 11/2002
11	Stomach Neoplasms (Stomach Cancer) 11/2021 - 01/2016
9	Disease Progression 01/2023 - 10/2010
8	Mesothelioma 02/2024 - 09/2006
5	Pneumonia (Pneumonitis) 01/2023 - 05/2009
5	Chronic Obstructive Pulmonary Disease (COPD) 01/2013 - 03/2006
4	Inflammation (Inflammations) 12/2022 - 05/2011
4	Adenocarcinoma 01/2020 - 01/2012
4	Adenocarcinoma of Lung 12/2018 - 01/2012
3	Neutropenia 01/2021 - 07/2012
3	Respiratory Insufficiency (Respiratory Failure) 09/2018 - 11/2014
3	Carcinogenesis 06/2012 - 02/2002
2	Thrombocytopenia (Thrombopenia) 01/2021 - 01/2013
2	Cachexia 01/2021 - 08/2013
2	Esophagitis 01/2020 - 08/2018
2	Exanthema (Rash) 03/2019 - 01/2015
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2019 - 08/2018
2	Carcinoma (Carcinomatosis) 08/2018 - 05/2018
2	Lymphatic Metastasis 09/2017 - 02/2016
2	Brain Neoplasms (Brain Tumor) 02/2017 - 09/2004
2	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2017 - 10/2014
2	Idiopathic Pulmonary Fibrosis 01/2017 - 01/2014
2	Pulmonary Alveolar Proteinosis 01/2017 - 11/2014
2	Idiopathic Interstitial Pneumonias 01/2017 - 10/2014
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 11/2014 - 07/2012
2	Lung Diseases (Lung Disease) 11/2014 - 01/2013
2	Emphysema 10/2013 - 05/2011
2	Lymphoma (Lymphomas) 07/2013 - 08/2011
2	Fibrosis (Cirrhosis) 07/2012 - 03/2006
1	Necrosis 01/2023
1	Empyema 12/2022
1	Graft vs Host Disease (Graft-Versus-Host Disease) 08/2022

Drug/Important Bio-Agent (IBA)

14	Immune Checkpoint InhibitorsIBA 01/2024 - 08/2018
11	NivolumabIBA 01/2024 - 05/2018
11	TetraspaninsIBA 01/2018 - 02/2003
10	ErbB Receptors (EGF Receptor)IBA 01/2023 - 09/2004
9	Gefitinib (Iressa)FDA Link 01/2023 - 09/2004
8	Pemetrexed (MTA)FDA Link 01/2023 - 07/2012
8	Proteins (Proteins, Gene)FDA Link 10/2019 - 02/2002
6	pembrolizumabIBA 01/2024 - 01/2021
6	Tyrosine Kinase InhibitorsIBA 12/2018 - 09/2004
5	PlatinumIBA 01/2024 - 10/2011
5	CytokinesIBA 12/2022 - 08/2005
5	Trastuzumab (Herceptin)FDA Link 01/2021 - 03/2015
5	Erlotinib Hydrochloride (CP 358,774)FDA Link 10/2019 - 04/2012
5	Carboplatin (JM8)FDA LinkGeneric 05/2019 - 01/2013
5	Phosphotransferases (Kinase)IBA 07/2013 - 01/2003
4	Biomarkers (Surrogate Marker)IBA 02/2024 - 05/2012
4	AsbestosIBA 01/2023 - 08/2018
4	B7-H1 AntigenIBA 06/2022 - 01/2021
4	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 01/2017
4	Bevacizumab (Avastin)FDA Link 01/2021 - 01/2013
4	Irinotecan (Camptosar)FDA LinkGeneric 01/2021 - 04/2012
3	IpilimumabIBA 01/2024 - 03/2023
3	LigandsIBA 11/2023 - 03/2021
3	ChemokinesIBA 12/2022 - 06/2012
3	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 11/2021 - 01/2012
3	Gemcitabine FDA Link 01/2021 - 01/2013
3	Paclitaxel (Taxol)FDA LinkGeneric 05/2019 - 01/2013
3	Fluorouracil (Carac)FDA LinkGeneric 01/2019 - 10/2011
3	Therapeutic UsesIBA 01/2017 - 01/2016
3	IntegrinsIBA 10/2006 - 03/2002
2	osimertinibIBA 01/2023 - 02/2017
2	CarbohydratesIBA 11/2021 - 05/2020
2	Monoclonal AntibodiesIBA 06/2021 - 03/2021
2	Indocyanine Green (Cardio-Green)FDA LinkGeneric 09/2018 - 06/2016
2	Vinorelbine (Navelbine)FDA LinkGeneric 08/2018 - 01/2013
2	Fibrinogen (Factor I)FDA Link 02/2017 - 01/2016
2	AutoantibodiesIBA 01/2017 - 11/2014
2	Oxycodone (Oxycontin)FDA LinkGeneric 01/2014 - 08/2006
2	Pancreatic Elastase (Elastase)IBA 10/2013 - 05/2011
2	AdiponectinIBA 10/2013 - 05/2011
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 07/2013 - 08/2011
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2013 - 03/2002
2	Chemokine CXCL12IBA 05/2012 - 11/2002
2	tyrosine receptor (receptor, tyrosine)IBA 01/2004 - 01/2003
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2003 - 02/2002
1	nintedanibIBA 01/2023
1	dacomitinibIBA 01/2023
1	Proton Pump InhibitorsIBA 01/2023
1	Glucose (Dextrose)FDA LinkGeneric 11/2022

Therapy/Procedure

38	Therapeutics 01/2024 - 01/2003
35	Drug Therapy (Chemotherapy) 01/2024 - 01/2003
6	Neoadjuvant Therapy 02/2024 - 01/2019
6	Immunotherapy 02/2024 - 01/2018
6	Radiotherapy 01/2021 - 09/2004
4	Chemoradiotherapy 08/2018 - 01/2016
3	Gastrectomy 01/2021 - 01/2020
3	Precision Medicine 01/2020 - 01/2019
3	Aftercare (After-Treatment) 01/2020 - 01/2008
2	Induction Chemotherapy 09/2022 - 01/2018
2	Combination Drug Therapy (Combination Chemotherapy) 01/2021 - 07/2012
2	Combined Modality Therapy 08/2018 - 01/2008
2	Lymph Node Excision (Lymph Node Dissection) 09/2017 - 02/2016
1	Debridement 12/2022