Jaap Keijer Selected Research

Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)

1/2020	Muscle Toxicity of Drugs: When Drugs Turn Physiology into Pathophysiology.
8/2011	Glycemic index differences of high-fat diets modulate primarily lipid metabolism in murine adipose tissue.

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Jaap Keijer Research Topics

Disease

20	Inflammation (Inflammations) 12/2023 - 09/2007
18	Obesity 03/2023 - 10/2002
15	Body Weight (Weight, Body) 01/2023 - 07/2005
12	Insulin Resistance 02/2022 - 09/2007
9	Neoplasms (Cancer) 12/2021 - 02/2007
6	Hypoxia (Hypoxemia) 11/2023 - 02/2008
5	Lung Neoplasms (Lung Cancer) 02/2011 - 05/2005
4	Fatty Liver 03/2023 - 04/2011
4	Metabolic Diseases (Metabolic Disease) 02/2023 - 09/2009
4	Mitochondrial Diseases (Mitochondrial Disease) 10/2022 - 02/2016
4	Cardiovascular Diseases (Cardiovascular Disease) 12/2021 - 01/2008
4	Infections 12/2009 - 09/2007
3	Hyperinsulinism (Hyperinsulinemia) 03/2023 - 12/2021
3	Chronic Disease (Chronic Diseases) 12/2021 - 01/2017
3	Weight Gain 02/2014 - 06/2005
3	Carcinogenesis 08/2010 - 07/2003
2	Type 2 Diabetes Mellitus (MODY) 12/2021 - 01/2018
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 01/2020
2	Glucose Intolerance 10/2019 - 02/2014
2	Non-alcoholic Fatty Liver Disease 12/2018 - 02/2014
2	Hypothyroidism 01/2017 - 04/2016
2	Starvation 02/2016 - 04/2015
2	Weight Loss (Weight Reduction) 05/2014 - 06/2006
2	Salmonella Infections (Salmonellosis) 12/2009 - 09/2007
2	Colorectal Neoplasms (Colorectal Cancer) 04/2008 - 07/2005
2	Colonic Neoplasms (Colon Cancer) 04/2008 - 12/2007
2	Adenoma (Adenomas) 09/2007 - 02/2007
1	Malnutrition (Nutritional Deficiencies) 06/2023
1	Sarcopenia 06/2023
1	Overweight 01/2023
1	Cardiac Arrhythmias (Arrythmia) 10/2022
1	Pellagra 02/2022
1	Leigh Disease (Leigh's Disease) 01/2022
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Mitochondrial complex I deficiency 01/2022
1	Dysbiosis 12/2021
1	Fibrosis (Cirrhosis) 12/2021
1	Liver Cirrhosis (Hepatic Cirrhosis) 12/2021

Drug/Important Bio-Agent (IBA)

12	Glucose (Dextrose)FDA LinkGeneric 10/2022 - 04/2009
11	LipidsIBA 03/2023 - 09/2007
9	Proteins (Proteins, Gene)FDA Link 10/2022 - 06/2006
8	Biomarkers (Surrogate Marker)IBA 03/2023 - 07/2003
7	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 02/2008
7	LeptinIBA 12/2021 - 08/2011
4	Oxygen (Dioxygen)IBA 11/2023 - 01/2015
4	AdiponectinIBA 09/2022 - 08/2011
4	CarbohydratesIBA 07/2019 - 03/2008
4	CholesterolIBA 04/2014 - 08/2011
4	Folic Acid (Vitamin M)FDA LinkGeneric 06/2011 - 02/2007
4	beta Carotene (Betacarotene)FDA Link 12/2009 - 07/2005
3	Blood Glucose (Blood Sugar)IBA 11/2023 - 06/2006
3	Adenosine Triphosphate (ATP)IBA 11/2023 - 01/2014
3	CalciumIBA 10/2022 - 12/2007
3	Galactose (Galactopyranose)FDA LinkGeneric 09/2022 - 01/2019
3	Niacinamide (Nicotinamide)FDA LinkGeneric 02/2022 - 02/2008
3	Carotenoids (Carotene)IBA 12/2021 - 01/2017
3	Messenger RNA (mRNA)IBA 11/2019 - 12/2007
3	Insulin (Novolin)FDA Link 01/2019 - 05/2014
3	Triglycerides (Triacylglycerol)IBA 10/2017 - 08/2011
3	QuercetinIBA 07/2015 - 07/2005
3	SeleniumIBA 09/2012 - 01/2008
3	Heme (Haem)IBA 09/2012 - 07/2003
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 09/2007
2	DiglyceridesIBA 01/2022 - 01/2022
2	CytokinesIBA 01/2022 - 01/2017
2	AntioxidantsIBA 12/2021 - 04/2016
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020 - 08/2011
2	FructoseIBA 01/2020 - 01/2018
2	nicotinamide-beta-ribosideIBA 10/2019 - 09/2019
2	Nonesterified Fatty Acids (NEFA)IBA 10/2017 - 06/2006
2	AdipokinesIBA 10/2017 - 01/2015
2	Thyroid HormonesIBA 03/2017 - 04/2016
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 02/2014 - 01/2012
2	Hormones (Hormone)IBA 02/2013 - 06/2005
2	ThiazolidinedionesIBA 01/2012 - 08/2011
2	Dietary Fats (Dietary Fat)IBA 08/2011 - 01/2011
2	PolyphenolsIBA 06/2011 - 02/2008
2	VitaminsIBA 06/2011 - 09/2007
2	EnzymesIBA 04/2011 - 06/2006
2	Methionine (L-Methionine)FDA Link 04/2011 - 04/2008
2	Pancreatitis-Associated ProteinsIBA 12/2009 - 09/2007
2	AsbestosIBA 01/2009 - 05/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2008 - 02/2008
2	Complementary DNA (cDNA)IBA 06/2006 - 10/2002
1	Amyloid (Amyloid Fibrils)IBA 12/2023
1	Staphylococcal Protein A (Protein A)IBA 12/2023
1	Interleukin-8 (Interleukin 8)IBA 01/2023
1	Tricarboxylic AcidsIBA 01/2022
1	Isoleucine (L-Isoleucine)FDA Link 01/2022
1	Lipid PeroxidesIBA 01/2022
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2022
1	CeramidesIBA 01/2022
1	ChemokinesIBA 01/2022
1	Valine (L-Valine)FDA Link 01/2022
1	CollagenIBA 12/2021
1	Butyrates (Butyrate)IBA 12/2021

Therapy/Procedure

5	Fat-Restricted Diet (Diet, Fat Restricted) 05/2014 - 06/2006
2	Diet Therapy (Therapy, Diet) 05/2014 - 06/2006
1	Denervation 11/2023
1	Caloric Restriction 06/2023