Makoto Kawai Selected Research

Liver Diseases (Liver Disease)

1/2009	Synthesis and structure-activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease.
4/2003	High-molecular-mass isoform of aminopeptidase N/CD13 in serum from cholestatic patients.

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Makoto Kawai Research Topics

Disease

15	Heart Failure 01/2023 - 04/2007
11	Cardiovascular Diseases (Cardiovascular Disease) 10/2023 - 04/2007
8	Human Influenza (Influenza) 01/2021 - 10/2016
7	Heart Diseases (Heart Disease) 01/2019 - 07/2009
5	Insulin Resistance 01/2023 - 03/2016
5	Infections 01/2022 - 01/2019
5	Fibrosis (Cirrhosis) 01/2020 - 04/2003
5	Hypertension (High Blood Pressure) 12/2008 - 10/2002
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2017 - 01/2014
4	Hypertrophy 06/2014 - 08/2006
3	Wounds and Injuries (Trauma) 03/2024 - 12/2009
3	Acute Coronary Syndrome 10/2023 - 01/2017
3	Fabry Disease (Fabry's Disease) 06/2022 - 01/2018
3	Ischemia 03/2021 - 12/2013
3	Left Ventricular Dysfunction 01/2021 - 01/2017
3	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2020 - 08/2006
2	Myocardial Infarction 10/2023 - 09/2007
2	Thrombosis (Thrombus) 10/2023 - 07/2011
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 06/2022 - 11/2011
2	Pneumonia (Pneumonitis) 01/2022 - 09/2007
2	Influenza in Birds (Avian Flu) 01/2022 - 01/2019
2	Pathologic Constriction (Stenosis) 01/2022 - 01/2017
2	Hypoxia (Hypoxemia) 01/2021 - 06/2006
2	Hyperglycemia 03/2020 - 10/2002
2	Dyslipidemias (Dyslipidemia) 03/2020 - 09/2007
2	Obesity 01/2017 - 07/2016
2	Sleepiness 01/2016 - 11/2015
2	Apnea 01/2016 - 01/2016
2	Cardiomegaly (Heart Hypertrophy) 06/2014 - 07/2009
2	Atrial Fibrillation 01/2014 - 09/2007
2	Inflammation (Inflammations) 01/2010 - 06/2007
2	Liver Diseases (Liver Disease) 01/2009 - 04/2003
2	Stroke (Strokes) 09/2007 - 04/2007
2	Cholestasis 02/2006 - 04/2003
1	Cerebral Infarction 10/2023
1	Mental Disorders (Mental Disorder) 08/2022
1	Pulmonary Vein Stenosis 01/2022
1	Virus Diseases (Viral Diseases) 01/2022
1	Ankle Injuries (Ankle Injury) 08/2021
1	Invasive Fungal Infections 01/2021
1	Arteriosclerosis 01/2021
1	Pulmonary Hypertension 01/2021
1	Cognitive Dysfunction 01/2020
1	Body Weight (Weight, Body) 01/2019

Drug/Important Bio-Agent (IBA)

13	Brain Natriuretic Peptide (Natrecor)FDA Link 10/2023 - 01/2010
7	EndonucleasesIBA 01/2021 - 10/2016
5	Natriuretic PeptidesIBA 10/2023 - 03/2016
5	Angiotensin Receptor AntagonistsIBA 01/2023 - 08/2006
5	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 10/2002
4	Uric Acid (Urate)IBA 01/2023 - 04/2013
4	baloxavirIBA 01/2022 - 01/2018
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2016
4	CreatinineIBA 03/2016 - 09/2007
3	Insulin (Novolin)FDA Link 01/2023 - 09/2007
3	Antiviral Agents (Antivirals)IBA 01/2022 - 11/2020
3	Phosphates (Orthophosphate)IBA 01/2022 - 01/2019
3	Oseltamivir (Tamiflu)FDA Link 01/2022 - 01/2019
3	AcidsIBA 01/2021 - 10/2016
3	oxidized low density lipoproteinIBA 01/2021 - 01/2017
3	Proteins (Proteins, Gene)FDA Link 11/2018 - 06/2014
2	Anesthetics (Anesthetic Agents)IBA 03/2024 - 08/2022
2	omega-Chloroacetophenone (Mace)IBA 10/2023 - 07/2011
2	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2023 - 03/2022
2	Neprilysin (Neutral Endopeptidase)IBA 01/2023 - 03/2022
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2023 - 12/2008
2	Malondialdehyde (Propanedial)IBA 01/2021 - 03/2020
2	LipidsIBA 01/2021 - 03/2020
2	LDL Lipoproteins (beta Lipoproteins)IBA 01/2021 - 03/2020
2	Therapeutic UsesIBA 01/2021 - 01/2019
2	Oxygen (Dioxygen)IBA 01/2021 - 01/2016
2	GadoliniumIBA 01/2020 - 11/2011
2	SodiumIBA 06/2014 - 12/2013
2	C-Reactive ProteinIBA 01/2010 - 06/2007
2	AldosteroneIBA 07/2009 - 08/2006
2	Adrenal Cortex Hormones (Corticosteroids)IBA 09/2007 - 06/2007
2	Protein Isoforms (Isoforms)IBA 02/2006 - 04/2003
1	Adrenocorticotropic Hormone (ACTH)FDA Link 10/2023
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2023
1	GlycosphingolipidsIBA 06/2022
1	sacubitril and valsartan sodium hydrate drug combinationIBA 03/2022
1	NitratesIBA 03/2021
1	Guanidine (Guanidine Nitrate)FDA Link 01/2021
1	Voriconazole (Vfend)FDA LinkGeneric 01/2021
1	Antifungal AgentsIBA 01/2021
1	low density lipoprotein inhibitorIBA 01/2021
1	Ergosterol (Lumisterol)IBA 01/2021
1	Vasodilator Agents (Vasodilators)IBA 01/2021
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2020
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2019
1	favipiravirIBA 01/2019
1	Viral RNAIBA 12/2018
1	Midazolam (Versed)FDA LinkGeneric 11/2018

Therapy/Procedure

8	Therapeutics 01/2022 - 06/2006
3	Aftercare (After-Treatment) 01/2017 - 09/2012
2	Stents 10/2023 - 07/2011
1	Catheter Ablation 01/2022
1	Braces 08/2021
1	Enzyme Replacement Therapy 01/2020
1	Oral Administration 01/2019
1	Treatment Delay 01/2019