P Kaplan Selected Research

imiglucerase

4/2009	A randomized trial comparing the efficacy and safety of imiglucerase (Cerezyme) infusions every 4 weeks versus every 2 weeks in the maintenance therapy of adult patients with Gaucher disease type 1.
5/2008	Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study.

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P Kaplan Research Topics

Disease

3	Gaucher Disease (Gaucher's Disease) 04/2009 - 10/2000
2	Ischemia 01/2015 - 01/2009
2	Neoplasms (Cancer) 01/2012 - 04/2001
2	Hypoxia (Hypoxemia) 01/2012 - 06/2007
2	Bone Diseases (Bone Disease) 04/2009 - 05/2008
1	Brain Ischemia (Cerebral Ischemia) 09/2009
1	Heart Diseases (Heart Disease) 06/2008
1	Metabolic Bone Diseases (Osteopenia) 05/2008
1	Bone Resorption 05/2008
1	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2007
1	Parkinson Disease (Parkinson's Disease) 11/2002
1	Endometrial Neoplasms (Endometrial Cancer) 04/2001
1	Hypoglycemia (Reactive Hypoglycemia) 04/2001
1	Hyperplasia 04/2001
1	Breast Neoplasms (Breast Cancer) 04/2001
1	Cytochrome-c Oxidase Deficiency 05/2000
1	Hyperammonemia 02/2000
1	Familial Primary Pulmonary Hypertension 02/2000

Drug/Important Bio-Agent (IBA)

3	Proteins (Proteins, Gene)FDA Link 01/2015 - 06/2008
2	imiglucerase FDA Link 04/2009 - 05/2008
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2009 - 05/2000
2	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 11/2002 - 04/2001
1	Hypoxia-Inducible Factor 1IBA 01/2012
1	Glucose (Dextrose)FDA LinkGeneric 01/2012
1	Adenosine Triphosphatases (ATPase)IBA 09/2009
1	Hemoglobins (Hemoglobin)IBA 04/2009
1	Glucosylceramidase (Glucocerebrosidase)IBA 04/2009
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2009
1	Peptides (Polypeptides)IBA 01/2009
1	Reactive Nitrogen SpeciesIBA 06/2008
1	LipidsIBA 06/2008
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2008
1	Biomarkers (Surrogate Marker)IBA 05/2008
1	Oxidants (Oxidizing Agents)IBA 08/2007
1	sigma Receptors (sigma Receptor)IBA 06/2007
1	Growth Differentiation FactorsIBA 11/2002
1	Tamoxifen FDA LinkGeneric 04/2001
1	Phorbol EstersIBA 04/2001
1	Nerve Growth Factors (Neurotrophins)IBA 04/2001
1	Estrogens (Estrogen)FDA Link 04/2001
1	Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA 02/2000
1	NitrogenIBA 02/2000

Therapy/Procedure

4	Therapeutics 01/2012 - 10/2000
1	Enzyme Replacement Therapy 05/2008
1	Transplantation 02/2000
1	Lung Transplantation 02/2000
1	Total Parenteral Nutrition 02/2000