Soosung Kang Selected Research

Neoplasms (Cancer)

12/2022	Structure, Function, and Inhibitors of the Mitochondrial Chaperone TRAP1.
1/2022	Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6-chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity.
12/2021	Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site.
7/2021	Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.
11/2020	Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics.
1/2020	Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.
1/2020	Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.
8/2018	Evolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery.
1/2018	Exploring G Protein-Coupled Receptors (GPCRs) Ligand Space via Cheminformatics Approaches: Impact on Rational Drug Design.
1/2015	Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability.

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Soosung Kang Research Topics

Disease

11	Neoplasms (Cancer) 12/2022 - 10/2013
3	Inflammation (Inflammations) 12/2023 - 08/2018
3	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2015 - 10/2014
3	Parkinson Disease (Parkinson's Disease) 07/2013 - 01/2012
2	Body Weight (Weight, Body) 12/2023 - 11/2015
2	Carcinogenesis 01/2022 - 01/2020
1	Fibrosis (Cirrhosis) 12/2023
1	Hypersensitivity (Allergy) 01/2023
1	Alzheimer Disease (Alzheimer's Disease) 12/2022
1	Prostatic Neoplasms (Prostate Cancer) 11/2020
1	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 12/2019
1	Hypothermia 12/2019
1	Neuroinflammatory Diseases 01/2019
1	Central Nervous System Diseases (CNS Diseases) 01/2019
1	Heart Diseases (Heart Disease) 01/2018
1	Adenoma (Adenomas) 04/2016
1	Gliosis 11/2015
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 11/2015
1	Osteoporosis 01/2015
1	Infections 01/2015
1	Pain (Aches) 10/2014
1	Neuralgia (Stump Neuralgia) 10/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2013

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 12/2022 - 08/2018
3	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 07/2013 - 01/2012
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2022 - 01/2020
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2022 - 07/2021
2	EnzymesIBA 11/2020 - 10/2014
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2015 - 10/2014
1	Janus Kinase 1IBA 12/2023
1	CollagenIBA 12/2023
1	Bleomycin (Blenoxane)FDA LinkGeneric 12/2023
1	PiperazineIBA 01/2023
1	Translationally-Controlled 1 Tumor ProteinIBA 01/2023
1	OvalbuminIBA 01/2023
1	Meclizine (Meclozine)FDA LinkGeneric 01/2023
1	Histamine Antagonists (Antihistamines)IBA 01/2023
1	IndazolesIBA 12/2022
1	glutaminyl-peptide cyclotransferaseIBA 12/2022
1	Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA 12/2022
1	Amyloid (Amyloid Fibrils)IBA 12/2022
1	mitoquinoneIBA 12/2021
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 12/2021
1	GSK2194069IBA 11/2020
1	4- (1- (5- (3,4- dimethyl- 1H- pyrazol- 5- yl)- 2,4- dimethylbenzoyl)azetidin- 3- yl)benzonitrileIBA 11/2020
1	LipidsIBA 11/2020
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 11/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020
1	TNF Receptor-Associated Factor 1IBA 01/2020
1	N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA 01/2019
1	Fluorine-18IBA 01/2019
1	rubimaillinIBA 08/2018
1	LigandsIBA 01/2018
1	AldosteroneIBA 04/2016
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2015
1	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 11/2015
1	Citalopram FDA LinkGeneric 11/2015
1	Ataxin-3IBA 11/2015
1	polyglutamineIBA 11/2015
1	CholesterolIBA 01/2015
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2015
1	Protein Isoforms (Isoforms)IBA 10/2014
1	ResveratrolIBA 10/2013
1	Calcium Channels (Calcium Channel)IBA 06/2013
1	CalciumIBA 06/2013
1	Oxidants (Oxidizing Agents)IBA 01/2012

Therapy/Procedure

2	Therapeutics 01/2020 - 01/2012