Nabil Kaci Selected Research

Achondroplasia

4/2024	Low-Dose Infigratinib Increases Bone Growth And Corrects Growth Plate Abnormalities In An Achondroplasia Mouse Model.
1/2022	Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia.
10/2021	Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth.
1/2018	Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.
1/2016	Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model.
12/2012	Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia.
2/2012	A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model.

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Nabil Kaci Research Topics

Disease

7	Achondroplasia 04/2024 - 02/2012
6	Dwarfism 01/2023 - 02/2012
1	Crouzon Syndrome With Acanthosis Nigricans 01/2022
1	Craniosynostoses (Craniosynostosis) 01/2022
1	Achondroplastic dwarfism 10/2021
1	Acromesomelic dysplasia 10/2021
1	Thanatophoric Dysplasia (Dwarfism, Thanatophoric) 01/2018

Drug/Important Bio-Agent (IBA)

9	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 04/2024 - 02/2012
2	infigratinibIBA 04/2024 - 01/2016
2	Guanylate Cyclase (Guanylyl Cyclase)IBA 10/2021 - 10/2021
1	Natriuretic PeptidesIBA 10/2021
1	Cyclic GMPIBA 10/2021
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2016
1	Tyrosine Kinase InhibitorsIBA 01/2016

Therapy/Procedure

1	Sutures (Suture) 01/2022