Hualiang Jiang Selected Research

COVID-19

10/2023	Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir.
1/2023	A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir.
1/2023	Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19.
12/2022	In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2.
10/2021	Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study.
10/2021	Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial.
1/2021	Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.
1/2021	Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs.
10/2020	Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19.
10/2020	Erratum to: Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19.

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Hualiang Jiang Research Topics

Disease

76	Neoplasms (Cancer) 04/2024 - 05/2004
16	Inflammation (Inflammations) 11/2023 - 12/2004
13	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 11/2003
12	Leukemia 02/2023 - 02/2007
12	Infections 10/2021 - 02/2005
10	COVID-19 10/2023 - 10/2020
9	Carcinogenesis 01/2022 - 05/2008
8	Type 2 Diabetes Mellitus (MODY) 01/2022 - 01/2007
7	Breast Neoplasms (Breast Cancer) 05/2022 - 04/2010
6	Amyloid Plaque 11/2017 - 04/2005
5	Schizophrenia (Dementia Praecox) 01/2021 - 09/2007
4	Heart Failure 02/2023 - 01/2013
4	Renal Cell Carcinoma (Grawitz Tumor) 01/2021 - 12/2016
4	Hepatocellular Carcinoma (Hepatoma) 12/2018 - 06/2008
4	Hypertension (High Blood Pressure) 01/2013 - 12/2004
4	Influenza in Birds (Avian Flu) 08/2012 - 06/2006
4	Rupture 04/2007 - 09/2003
3	Colorectal Neoplasms (Colorectal Cancer) 04/2024 - 07/2009
3	Bites and Stings (Sting) 12/2023 - 01/2023
3	Colitis 11/2022 - 01/2021
3	Central Nervous System Diseases (CNS Diseases) 07/2022 - 10/2019
3	Dyslipidemias (Dyslipidemia) 01/2022 - 12/2004
3	Parkinson Disease (Parkinson's Disease) 01/2021 - 12/2013
3	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 04/2010
3	Pulmonary Arterial Hypertension 01/2021 - 06/2010
3	Neoplasm Metastasis (Metastasis) 07/2020 - 06/2008
3	Lymphoma (Lymphomas) 01/2020 - 11/2014
3	Virus Diseases (Viral Diseases) 01/2020 - 09/2012
3	Malaria 12/2017 - 01/2009
3	Cardiovascular Diseases (Cardiovascular Disease) 11/2017 - 07/2011
3	Obesity 01/2015 - 01/2007
3	Insulin Resistance 01/2013 - 01/2011
3	Human Influenza (Influenza) 09/2012 - 10/2010
3	Metabolic Diseases (Metabolic Disease) 03/2011 - 01/2011
3	Severe Acute Respiratory Syndrome 01/2008 - 06/2005
2	Communicable Diseases (Infectious Diseases) 01/2023 - 01/2020
2	Hyperlipidemias (Hyperlipidemia) 01/2022 - 11/2019
2	Fibrosis (Cirrhosis) 01/2021 - 01/2013
2	Catalepsy 10/2020 - 02/2018
2	Critical Illness (Critically Ill) 10/2020 - 10/2020

Drug/Important Bio-Agent (IBA)

33	Proteins (Proteins, Gene)FDA Link 02/2023 - 02/2005
10	EnzymesIBA 05/2017 - 08/2005
9	Peptide Hydrolases (Proteases)FDA Link 10/2023 - 03/2005
9	MethyltransferasesIBA 02/2019 - 11/2014
8	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 07/2009
6	Amyloid (Amyloid Fibrils)IBA 01/2022 - 09/2006
5	Phosphotransferases (Kinase)IBA 12/2023 - 09/2012
5	LigandsIBA 01/2021 - 06/2007
5	Anti-Bacterial Agents (Antibiotics)IBA 02/2019 - 11/2006
5	Neuraminidase (Sialidase)IBA 09/2012 - 06/2006
4	Lysine (L-Lysine)FDA Link 02/2023 - 10/2015
4	Glycoproteins (Glycoprotein)IBA 10/2021 - 02/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021 - 04/2010
4	Phosphodiesterase 5 InhibitorsIBA 01/2021 - 06/2010
4	Arginine (L-Arginine)FDA Link 02/2019 - 12/2014
4	Blood Glucose (Blood Sugar)IBA 10/2013 - 09/2006
3	InterferonsIBA 12/2023 - 01/2023
3	RNA (Ribonucleic Acid)IBA 10/2023 - 01/2021
3	Messenger RNA (mRNA)IBA 10/2023 - 01/2015
3	Antiviral Agents (Antivirals)IBA 01/2023 - 01/2021
3	Dextran SulfateIBA 11/2022 - 01/2021
3	AcetylcholinesteraseIBA 10/2022 - 03/2013
3	Therapeutic UsesIBA 01/2022 - 06/2010
3	CytokinesIBA 01/2022 - 01/2020
3	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2021 - 10/2020
3	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2021 - 05/2017
3	Sorting NexinsIBA 01/2021 - 01/2020
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2020 - 01/2017
3	nitroxolineIBA 02/2019 - 11/2017
3	ErbB Receptors (EGF Receptor)IBA 01/2018 - 05/2004
3	Histones (Histone)IBA 01/2017 - 02/2014
3	Amyloid beta-PeptidesIBA 04/2013 - 04/2005
3	huperzine AIBA 04/2013 - 11/2003
3	Insulin (Novolin)FDA Link 01/2013 - 01/2007
3	Zanamivir (Relenza)FDA Link 09/2012 - 10/2006
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2012 - 03/2005
3	PPAR gammaIBA 12/2008 - 12/2004
2	Irinotecan (Camptosar)FDA LinkGeneric 04/2024 - 02/2007
2	NucleotidesIBA 11/2023 - 01/2021
2	N-methyladenosineIBA 10/2023 - 01/2015
2	magnololIBA 01/2023 - 01/2011
2	remdesivirIBA 12/2022 - 01/2021
2	Peptidylprolyl Isomerase (Prolyl Isomerase)IBA 10/2022 - 06/2007
2	Antineoplastic Agents (Antineoplastics)IBA 07/2022 - 07/2012
2	Purinergic P1 Receptors (Adenosine Receptor)IBA 06/2022 - 11/2021
2	Histone Deacetylases (Histone Deacetylase)IBA 11/2021 - 09/2010
2	Apoptosis Regulatory ProteinsIBA 10/2021 - 04/2010
2	Hormones (Hormone)IBA 10/2021 - 09/2012
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2021 - 01/2019
2	Interleukin-6 (Interleukin 6)IBA 10/2020 - 01/2020
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2020 - 01/2012
2	SphingolipidsIBA 01/2020 - 01/2014
2	Chloroquine (Aralen)FDA LinkGeneric 01/2020 - 09/2002
2	CholesterolIBA 01/2020 - 08/2012
2	Small Interfering RNA (siRNA)IBA 01/2020 - 08/2014

Therapy/Procedure

34	Therapeutics 04/2024 - 05/2008
5	Drug Therapy (Chemotherapy) 01/2020 - 06/2003
4	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2023 - 11/2003
2	Immunotherapy 10/2023 - 01/2022
2	Artificial Respiration (Mechanical Ventilation) 10/2020 - 10/2020