Magdalena Jastrzębska-Więsek Selected Research

Antidepressive Agents (Antidepressants)

2/2023	Hybrid molecules combining GABA-A and serotonin 5-HT6 receptors activity designed to tackle neuroinflammation associated with depression.
9/2022	The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.
4/2022	Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia.
1/2022	The selective 5-HT 1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat.
1/2020	The preclinical discovery and development of paliperidone for the treatment of schizophrenia.
1/2019	Novel antagonists of 5-HT6 and/or 5-HT7 receptors affect the brain monoamines metabolism and enhance the anti-immobility activity of different antidepressants in rats.
1/2017	Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.
1/2013	Partial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays.

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Magdalena Jastrzębska-Więsek Research Topics

Disease

7	Dementia (Dementias) 09/2022 - 01/2013
5	Cognitive Dysfunction 10/2021 - 06/2016
4	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 06/2022
4	Memory Disorders (Memory Loss) 09/2022 - 06/2016
3	Psychotic Disorders (Schizoaffective Disorder) 11/2023 - 06/2016
3	Obesity 12/2019 - 01/2013
2	Weight Gain 01/2023 - 09/2022
2	Central Nervous System Diseases (CNS Diseases) 01/2021 - 12/2019
2	Schizophrenia (Dementia Praecox) 01/2020 - 01/2018
1	Inflammation (Inflammations) 09/2023
1	Anxiety Disorders (Anxiety Disorder) 03/2023
1	Neuroinflammatory Diseases 02/2023
1	Abdominal Obesity 01/2023
1	Dyslipidemias (Dyslipidemia) 01/2023
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2023
1	Hyperglycemia 01/2023
1	Parkinsonian Disorders (Parkinsonism) 01/2022
1	Chorea (Rheumatic Chorea) 01/2022
1	Huntington Disease (Huntington's Disease) 01/2022
1	Catalepsy 01/2022
1	Motor Disorders 01/2022
1	Dyskinesias (Dyskinesia) 01/2022
1	Treatment-Resistant Depressive Disorder 01/2019
1	Mania (Manias) 01/2018
1	Mental Disorders (Mental Disorder) 01/2018
1	Body Weight (Weight, Body) 01/2017
1	Pica (Geophagia) 01/2017
1	Tics (Tic) 03/2015
1	Mood Disorders (Mood Disorder) 12/2014

Drug/Important Bio-Agent (IBA)

8	Antidepressive Agents (Antidepressants)IBA 02/2023 - 01/2013
5	Serotonin (5 Hydroxytryptamine)IBA 11/2023 - 01/2022
5	LigandsIBA 11/2023 - 07/2019
4	Serotonin ReceptorsIBA 01/2024 - 07/2019
3	Antipsychotic Agents (Antipsychotics)IBA 01/2023 - 01/2017
3	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 01/2017
3	Anti-Anxiety Agents (Anxiolytics)IBA 12/2019 - 01/2013
2	TriazinesIBA 11/2023 - 12/2019
2	3- benzenesulfonyl- 8- piperazin- 1- ylquinolineIBA 01/2023 - 06/2016
2	serotonin 6 receptorIBA 10/2021 - 03/2015
1	SeleniumIBA 01/2024
1	Ether (Diethyl Ether)IBA 11/2023
1	Formaldehyde (Formol)FDA Link 09/2023
1	N-dodecyl-L-lysine amideIBA 09/2023
1	CarrageenanIBA 09/2023
1	HBK-15IBA 03/2023
1	gamma-Aminobutyric Acid (GABA)IBA 02/2023
1	N(1)- (6- chloroimidazo(2,1- b)(1,3)thiazole- 5- sulfonyl)tryptamineIBA 01/2023
1	Olanzapine (Zyprexa)FDA Link 01/2023
1	GhrelinIBA 01/2023
1	AdiponectinIBA 01/2023
1	Haloperidol (Haldol)FDA LinkGeneric 01/2023
1	Hormones (Hormone)IBA 01/2023
1	Insulin (Novolin)FDA Link 01/2023
1	LipidsIBA 01/2023
1	LeptinIBA 01/2023
1	Risperidone (Risperdal Consta)FDA LinkGeneric 01/2023
1	AntioxidantsIBA 09/2022
1	Triglycerides (Triacylglycerol)IBA 09/2022
1	EnzymesIBA 09/2022
1	CholesterolIBA 09/2022
1	Monoamine Oxidase (MAO)IBA 06/2022
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 04/2022
1	befiradolIBA 01/2022
1	Buspirone (Buspar)FDA LinkGeneric 01/2022
1	deutetrabenazineIBA 01/2022
1	Levodopa (L Dopa)FDA LinkGeneric 01/2022
1	Tetrabenazine (Nitoman)FDA Link 01/2022
1	AminesIBA 10/2021
1	Proteins (Proteins, Gene)FDA Link 10/2021
1	5-HT1A Serotonin ReceptorIBA 01/2021
1	Quetiapine Fumarate (Seroquel)FDA Link 04/2020
1	BenzoxazolesIBA 04/2020
1	Paliperidone Palmitate FDA Link 01/2020
1	HydantoinsIBA 12/2019
1	SulfonesIBA 12/2019
1	indoleIBA 12/2019
1	cariprazineIBA 01/2018
1	5- chloro- 2- methyl- 3- (1,2,3,6- tetrahydro- 4- pyridinyl)- 1H- indoleIBA 01/2017
1	Appetite Depressants (Anorectics)IBA 01/2017
1	Glycerol (Glycerine)FDA LinkGeneric 01/2017
1	Scopolamine (Hyoscine)FDA Link 01/2017
1	Dopamine (Intropin)FDA LinkGeneric 01/2017
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2017
1	ADN-1184IBA 06/2016
1	AmidesIBA 03/2015
1	Theophylline (Theon)FDA LinkGeneric 12/2014

Therapy/Procedure

4	Therapeutics 04/2022 - 01/2017