Akio Inui Selected Research

Neoplasms (Cancer)

1/2023	Anamorelin in Japanese patients with cancer cachexia: an update.
12/2021	Application of Kampo medicines for the palliation of cancer cachexia.
1/2021	The regulatory approval of anamorelin for treatment of cachexia in patients with non-small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer in Japan: facts and numbers.
6/2019	Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia.
1/2018	Herbal Medicine Ninjin'yoeito in the Treatment of Sarcopenia and Frailty.
1/2016	Increased Ghrelin but Low Ghrelin-Reactive Immunoglobulins in a Rat Model of Methotrexate Chemotherapy-Induced Anorexia.
1/2015	The translational aspect of complementary and alternative medicine for cancer with particular emphasis on Kampo.
1/2015	Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer.
1/2015	Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma.
1/2014	Hesperidin potentiates ghrelin signaling.

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Akio Inui Research Topics

Disease

37	Neoplasms (Cancer) 01/2023 - 02/2002
30	Body Weight (Weight, Body) 01/2023 - 02/2002
29	Anorexia 01/2021 - 02/2002
24	Cachexia 01/2023 - 02/2002
21	Obesity 01/2021 - 02/2003
16	Anorexia Nervosa 09/2015 - 12/2004
13	Weight Loss (Weight Reduction) 01/2023 - 03/2002
9	Insulin Resistance 01/2020 - 05/2003
8	Type 2 Diabetes Mellitus (MODY) 02/2016 - 05/2003
7	Hyperglycemia 01/2020 - 02/2006
7	AIDS-Related Complex (ARC) 01/2020 - 05/2003
5	Frailty 01/2024 - 01/2018
5	Fatigue 01/2022 - 06/2005
5	Diabetes Mellitus 01/2018 - 07/2008
5	Weight Gain 01/2018 - 06/2007
5	Feeding and Eating Disorders (Eating Disorder) 03/2015 - 01/2004
4	Heart Failure 06/2019 - 07/2008
4	Sarcopenia 06/2019 - 07/2005
4	Hyperphagia (Overeating) 01/2013 - 02/2006
4	Fatty Liver 03/2011 - 05/2003
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2023 - 01/2019
3	Inflammation (Inflammations) 01/2022 - 08/2003
3	Adult-onset citrullinemia type 2 01/2017 - 11/2012
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2016 - 01/2013
3	Hypoglycemia (Reactive Hypoglycemia) 09/2015 - 05/2006
3	Dyspepsia (Indigestion) 01/2015 - 04/2011
3	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2015 - 04/2011
3	Chronic Renal Insufficiency 04/2013 - 02/2008
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2013 - 12/2009
3	Chronic Obstructive Pulmonary Disease (COPD) 10/2011 - 07/2008
3	Starvation 10/2006 - 09/2004
2	Colorectal Neoplasms (Colorectal Cancer) 01/2023 - 01/2021
2	Stomach Neoplasms (Stomach Cancer) 01/2023 - 01/2021
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2023 - 01/2021
2	Chronic Disease (Chronic Diseases) 09/2015 - 07/2005
2	Colonic Neoplasms (Colon Cancer) 01/2015 - 11/2008
2	Infections 04/2013 - 10/2012
2	Taste Disorders (Taste Disorder) 04/2013 - 09/2011
2	Constipation 11/2012 - 01/2010

Drug/Important Bio-Agent (IBA)

39	GhrelinIBA 01/2021 - 05/2003
20	LeptinIBA 07/2013 - 06/2002
17	CytokinesIBA 12/2021 - 02/2002
16	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 05/2003
13	Insulin (Novolin)FDA Link 01/2021 - 09/2004
12	Hormones (Hormone)IBA 02/2016 - 07/2004
9	Peptides (Polypeptides)IBA 03/2015 - 05/2003
8	Neuropeptide YIBA 01/2020 - 05/2003
7	Serotonin (5 Hydroxytryptamine)IBA 08/2006 - 10/2002
6	ninjin'yoeitoIBA 01/2024 - 01/2018
6	des-n-octanoyl ghrelinIBA 12/2009 - 01/2005
5	Messenger RNA (mRNA)IBA 01/2022 - 07/2004
5	Proteins (Proteins, Gene)FDA Link 12/2021 - 07/2003
5	NeuropeptidesIBA 01/2021 - 07/2004
5	Ghrelin ReceptorsIBA 01/2021 - 06/2007
5	Appetite Depressants (Anorectics)IBA 01/2020 - 07/2004
5	liu-jun-zi-tangIBA 01/2015 - 01/2012
5	AdiponectinIBA 01/2014 - 09/2004
5	Branched-Chain Amino AcidsIBA 10/2006 - 03/2002
4	citrinIBA 01/2017 - 11/2012
4	Interleukin-6 (Interleukin 6)IBA 10/2013 - 07/2003
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2013 - 08/2003
4	acyl-ghrelinIBA 12/2009 - 01/2008
4	MelanocortinsIBA 05/2009 - 02/2003
4	Eicosapentaenoic AcidIBA 10/2006 - 03/2002
4	Thalidomide (Thalomid)FDA Link 10/2006 - 03/2002
4	MelatoninIBA 10/2006 - 03/2002
4	CannabinoidsIBA 10/2006 - 03/2002
3	Plant ExtractsIBA 01/2020 - 01/2012
3	Streptozocin (Streptozotocin)FDA Link 01/2020 - 01/2013
3	UrocortinsIBA 12/2019 - 05/2003
3	Protein Isoforms (Isoforms)IBA 09/2015 - 10/2012
3	Olanzapine (Zyprexa)FDA Link 08/2014 - 03/2007
3	Interleukin-1 (Interleukin 1)IBA 10/2013 - 07/2003
3	Therapeutic UsesIBA 01/2013 - 05/2009
3	LipidsIBA 10/2006 - 09/2004
2	anamorelinIBA 01/2023 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2003
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2022 - 01/2013
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2020 - 01/2016
2	Cisplatin (Platino)FDA LinkGeneric 01/2020 - 06/2019
2	Growth Hormone (Somatotropin)IBA 01/2018 - 09/2015
2	Glycerol (Glycerine)FDA LinkGeneric 01/2017 - 09/2015
2	Immunoglobulins (Immunoglobulin)IBA 01/2016 - 04/2012
2	Immunoglobulin G (IgG)IBA 01/2016 - 01/2013
2	growth hormone-releasing peptide-2 (KP 102)IBA 09/2015 - 11/2008
2	Glycerolphosphate Dehydrogenase (Glycerol 3 Phosphate Dehydrogenase)IBA 09/2015 - 11/2012
2	AutoantibodiesIBA 03/2015 - 04/2011
2	Caspase 3 (Caspase-3)IBA 01/2015 - 01/2015
2	Fluorouracil (Carac)FDA LinkGeneric 01/2015 - 11/2008
2	Blood Glucose (Blood Sugar)IBA 01/2014 - 05/2009
2	FructoseIBA 01/2014 - 09/2013
2	ZincIBA 04/2013 - 09/2011
2	CarbohydratesIBA 11/2012 - 08/2004

Therapy/Procedure

18	Therapeutics 01/2022 - 03/2002
11	Kampo Medicine (Kampo) 01/2023 - 11/2012
9	Drug Therapy (Chemotherapy) 05/2019 - 02/2002
5	Gastric Bypass (Roux-en-Y Gastric Bypass) 02/2016 - 08/2003
3	Oral Administration 06/2019 - 04/2013
2	Palliative Care (Palliative Therapy) 01/2018 - 11/2012
2	Bariatric Surgery 02/2017 - 02/2016