Federico Innocenti Selected Research

Irinotecan (Camptosar)

2/2024	Model-Based Prediction of Irinotecan-Induced Grade 4 Neutropenia in Cancer Patients: Influence of Incorporating Germline Genetic Factors in the Model.
12/2022	Evaluation of methylated DCR1 as a biomarker for response to adjuvant irinotecan-based therapy in stage III colon cancer: cancer and leukaemia Group B 89803 (Alliance).
7/2022	Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs.
1/2022	Integration of DNA sequencing with population pharmacokinetics to improve the prediction of irinotecan exposure in cancer patients.
1/2022	All You Need to Know About UGT1A1 Genetic Testing for Patients Treated With Irinotecan: A Practitioner-Friendly Guide.
1/2022	Model-Based Prediction of Irinotecan-Induced Grade 4 Neutropenia in Advanced Cancer Patients: Influence of Demographic and Clinical Factors.
1/2021	Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance).
1/2020	Optimal Sampling Strategies for Irinotecan (CPT-11) and its Active Metabolite (SN-38) in Cancer Patients.
2/2017	Genotype-Guided Dosing Study of FOLFIRI plus Bevacizumab in Patients with Metastatic Colorectal Cancer.
1/2017	Exceptional Chemotherapy Response in Metastatic Colorectal Cancer Associated With Hyper-Indel-Hypermutated Cancer Genome and Comutation of POLD1 and MLH1.

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Federico Innocenti Research Topics

Disease

73	Neoplasms (Cancer) 04/2024 - 05/2002
40	Colorectal Neoplasms (Colorectal Cancer) 12/2024 - 11/2004
14	Neutropenia 02/2024 - 05/2002
11	Pancreatic Neoplasms (Pancreatic Cancer) 05/2024 - 08/2010
10	Leukemia 03/2024 - 08/2010
10	Hypertension (High Blood Pressure) 12/2022 - 01/2016
4	Diarrhea 12/2022 - 11/2004
3	Colonic Neoplasms (Colon Cancer) 12/2024 - 01/2017
3	Genetic Risk Score 01/2022 - 01/2019
3	Proteinuria 01/2022 - 01/2016
3	Breast Neoplasms (Breast Cancer) 01/2019 - 05/2002
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2015 - 11/2007
2	Residual Neoplasm 12/2024 - 12/2020
2	Hypoxia (Hypoxemia) 02/2024 - 01/2022
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 07/2022 - 06/2007
2	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 01/2003
2	Type 2 Diabetes Mellitus (MODY) 12/2021 - 11/2016
2	Disease Progression 11/2020 - 12/2019
2	Lung Neoplasms (Lung Cancer) 08/2011 - 09/2009
1	Inflammation (Inflammations) 01/2024
1	Hepatitis C 01/2024
1	Hepatocellular Carcinoma (Hepatoma) 01/2024
1	Infections 01/2024
1	Chemical and Drug Induced Liver Injury 01/2023
1	Adenocarcinoma 07/2022
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 07/2022
1	Brain Neoplasms (Brain Tumor) 07/2022
1	Biliary Tract Neoplasms (Biliary Tract Cancer) 07/2022
1	Chronic Renal Insufficiency 01/2022
1	Essential Hypertension 01/2022
1	Anemia 01/2022
1	Fatigue 10/2021
1	Rectal Neoplasms (Rectal Cancer) 12/2020

Drug/Important Bio-Agent (IBA)

28	Irinotecan (Camptosar)FDA LinkGeneric 02/2024 - 05/2003
24	Bevacizumab (Avastin)FDA Link 03/2024 - 08/2010
15	DNA (Deoxyribonucleic Acid)IBA 12/2024 - 07/2009
12	Cetuximab (Erbitux)FDA Link 03/2024 - 01/2016
11	Biomarkers (Surrogate Marker)IBA 12/2024 - 01/2016
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2024 - 07/2015
9	Fluorouracil (Carac)FDA LinkGeneric 04/2024 - 05/2009
7	Proteins (Proteins, Gene)FDA Link 05/2024 - 08/2011
6	Leucovorin (Folinic Acid)FDA Link 01/2020 - 05/2009
6	Gemcitabine FDA Link 01/2019 - 01/2009
4	Sorafenib (BAY 43-9006)FDA Link 01/2024 - 01/2019
4	Antineoplastic Agents (Antineoplastics)IBA 01/2022 - 03/2003
4	Vitamin D FDA LinkGeneric 12/2019 - 08/2014
3	RNA (Ribonucleic Acid)IBA 03/2024 - 01/2022
3	LigandsIBA 01/2024 - 01/2014
3	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2021 - 12/2006
3	Genetic Markers (Genetic Marker)IBA 01/2021 - 04/2013
3	LipidsIBA 01/2020 - 05/2011
3	hydroxide ionIBA 12/2019 - 08/2014
3	ErbB Receptors (EGF Receptor)IBA 09/2009 - 03/2003
2	Long Noncoding RNAIBA 05/2024 - 12/2023
2	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 04/2024 - 11/2023
2	Monoclonal AntibodiesIBA 03/2024 - 01/2017
2	Topoisomerase InhibitorsIBA 07/2022 - 04/2009
2	BilirubinIBA 01/2022 - 04/2004
2	Blood Proteins (Serum Proteins)IBA 01/2022 - 01/2022
2	regorafenibIBA 01/2022 - 10/2020
2	Angiopoietin-2IBA 01/2022 - 01/2022
2	ORALIT (ORS)IBA 01/2022 - 04/2013
2	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 01/2022 - 01/2022
2	Metformin (Glucophage)FDA LinkGeneric 12/2021 - 11/2016
2	25-hydroxyvitamin DIBA 12/2019 - 08/2014
2	Angiogenesis InhibitorsIBA 01/2019 - 10/2018
2	Hormones (Hormone)IBA 12/2016 - 01/2016
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 09/2009 - 11/2007
2	Ketoconazole (Nizoral)FDA LinkGeneric 11/2007 - 11/2004
1	HLA-B Antigens (HLA-B)IBA 02/2024
1	Calcibiotic Root Canal SealerIBA 02/2024
1	Phosphotransferases (Kinase)IBA 02/2024
1	ChemokinesIBA 01/2024
1	Chemokine ReceptorsIBA 01/2024
1	TensinsIBA 01/2024
1	CTLA-4 AntigenIBA 01/2024
1	Programmed Cell Death 1 ReceptorIBA 01/2024
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2024
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2024
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2024
1	Amoxicillin (Wymox)FDA LinkGeneric 01/2023
1	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 01/2023
1	Taxoids (Taxanes)IBA 01/2023
1	Cytochrome P-450 CYP2C8IBA 01/2023
1	Circulating Tumor DNAIBA 01/2023
1	folfirinoxIBA 07/2022
1	Neurofibromin 1 (Neurofibromin)IBA 01/2022
1	NucleotidesIBA 01/2022
1	Prolyl-Hydroxylase InhibitorsIBA 01/2022
1	Glipizide (Glucotrol)FDA LinkGeneric 12/2021
1	AdiponectinIBA 01/2021
1	LuciferasesIBA 01/2021
1	Insulin-Like Growth Factor Binding ProteinsIBA 01/2021

Therapy/Procedure

34	Therapeutics 03/2024 - 08/2003
25	Drug Therapy (Chemotherapy) 05/2024 - 04/2010
2	Biological Therapy 12/2019 - 01/2017
1	Adjuvant Chemotherapy 12/2024
1	Immunotherapy 01/2024
1	Precision Medicine 01/2023
1	Drug Tapering 10/2021