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Patrick Imesch Selected Research

Vorinostat

9/2009MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells.
6/2009Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities.
9/2007The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells.

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Patrick Imesch Research Topics

Disease

17Endometriosis
12/2023 - 12/2010
13Neoplasms (Cancer)
06/2020 - 09/2007
4Endometrial Neoplasms (Endometrial Cancer)
06/2020 - 01/2009
4Breast Neoplasms (Breast Cancer)
06/2020 - 01/2014
2Pain (Aches)
01/2022 - 02/2019
1Migraine Disorders (Migraine)
12/2023
1Adenomyosis
01/2023
1Chronic Pain
01/2022
1Spontaneous Abortion (Miscarriage)
11/2017
1Neoplasm Metastasis (Metastasis)
06/2015
1Pathologic Complete Response
06/2015
1Carcinoma (Carcinomatosis)
09/2013
1Adenocarcinoma
01/2013
1Vulvar Neoplasms (Vulvar Cancer)
10/2011
1Hypoxia (Hypoxemia)
04/2011
1Colonic Neoplasms (Colon Cancer)
09/2007

Drug/Important Bio-Agent (IBA)

4Proteins (Proteins, Gene)FDA Link
01/2014 - 06/2009
3GTP-Binding Proteins (G-Protein)IBA
01/2014 - 04/2012
3Estrogen ReceptorsIBA
01/2014 - 04/2012
3Histone Deacetylase InhibitorsIBA
12/2013 - 09/2007
3VorinostatFDA Link
09/2009 - 09/2007
2dienogestFDA Link
06/2023 - 04/2019
2Progesterone Receptors (Progesterone Receptor)IBA
01/2023 - 04/2012
2Gonadal Steroid Hormones (Sex Hormones)IBA
01/2023 - 04/2012
2Estrogens (Estrogen)FDA Link
07/2016 - 09/2013
2Hormones (Hormone)IBA
06/2015 - 12/2013
2Histone Deacetylases (Histone Deacetylase)IBA
12/2013 - 10/2011
2romidepsin (FK228)FDA Link
04/2011 - 12/2010
2Valproic Acid (Depakote)FDA LinkGeneric
09/2009 - 09/2007
1Contraceptive Agents (Contraceptives)IBA
12/2023
1Analgesics (Analgesic Drugs)IBA
12/2023
1Estrogen Receptor alphaIBA
01/2023
1Estrogen Receptor betaIBA
01/2023
1Vitamin DFDA LinkGeneric
12/2022
1ibrutinibIBA
06/2020
1GelatinasesIBA
04/2019
1Matrix Metalloproteinases (MMPs)IBA
04/2019
1Progestins (Progestagens)IBA
04/2019
1vasectrin IIIIBA
11/2017
1Mercaptoethanol (2 Mercaptoethanol)IBA
07/2016
1Trastuzumab (Herceptin)FDA Link
06/2015
1human ERBB2 proteinIBA
06/2015
1NVP-BKM120IBA
07/2014
1MK 2206IBA
07/2014
1perifosineIBA
07/2014
1Phenobarbital (Luminal)FDA Link
01/2014
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2014
1Formaldehyde (Formol)FDA Link
01/2014
1Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2014
1ParaffinIBA
01/2014
1Histone Deacetylase 1IBA
12/2013
1P-2 (P 2)IBA
12/2013
1SteroidsIBA
12/2013
16-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA
09/2013
1Peptides (Polypeptides)IBA
09/2013
1Cytochromes c (Cytochrome c)IBA
09/2013
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
06/2012
1Biomarkers (Surrogate Marker)IBA
06/2012
1Messenger RNA (mRNA)IBA
02/2012
1Polynucleotide Adenylyltransferase (Polymerase, Poly A)IBA
02/2012
1Cytostatic AgentsIBA
02/2012
1cordycepinIBA
02/2012
1Interleukin-10 (Interleukin 10)IBA
09/2011
1Fibronectins (Fibronectin)IBA
09/2011
1CytokinesIBA
09/2011
1AntigensIBA
09/2011
1F8 monoclonal antibodyIBA
09/2011
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2011
1cobaltous chloride (cobalt(II)chloride)IBA
04/2011
1Poly AIBA
01/2011
1trichostatin A (A 300)IBA
09/2009
1Antineoplastic Agents (Antineoplastics)IBA
09/2009
1MutL Protein Homolog 1IBA
09/2009
1theasinensin AIBA
09/2009

Therapy/Procedure

5Therapeutics
01/2022 - 06/2015
1Pain Management
01/2022
1Traditional Medicine (Folk Remedies)
02/2019
1Complementary Therapies (Alternative Medicine)
02/2019
1Pelvic Exenteration
05/2016
1Lasers (Laser)
07/2013
1Aftercare (After-Treatment)
07/2013
1Sex Reassignment Surgery
01/2013
1Ovariectomy (Oophorectomy)
01/2013
1Lymph Node Excision (Lymph Node Dissection)
01/2009
1Hysterectomy
01/2009
1Salpingo-oophorectomy
01/2009