Richard Idro Selected Research

Nodding Syndrome

5/2024	Doxycycline for the treatment of nodding syndrome: a randomised, placebo-controlled, phase 2 trial.
1/2021	Systemic and cerebrospinal fluid immune and complement activation in Ugandan children and adolescents with long-standing nodding syndrome: A case-control study.
3/2020	Prevalence and incidence of nodding syndrome and other forms of epilepsy in onchocerciasis-endemic areas in northern Uganda after the implementation of onchocerciasis control measures.
1/2020	Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo.
3/2019	Doxycycline for the treatment of nodding syndrome (DONS); the study protocol of a phase II randomised controlled trial.
10/2018	Asymptomatic malaria parasitaemia and seizure control in children with nodding syndrome; a cross-sectional study.
1/2018	Nodding syndrome: recent insights into etiology, pathophysiology, and treatment.
1/2018	Setting up a clinical trial for a novel disease: a case study of the Doxycycline for the Treatment of Nodding Syndrome Trial - challenges, enablers and lessons learned.
4/2016	Is nodding syndrome an Onchocerca volvulus-induced neuroinflammatory disorder? Uganda's story of research in understanding the disease.
12/2015	Catatonia in Ugandan children with nodding syndrome and effects of treatment with lorazepam: a pilot study.

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Richard Idro Research Topics

Disease

31	Malaria 01/2024 - 04/2004
15	Cerebral Malaria 11/2023 - 09/2006
11	Nodding Syndrome 05/2024 - 11/2014
11	Seizures (Absence Seizure) 05/2024 - 07/2007
8	Anemia 01/2024 - 02/2008
7	Coma (Comas) 01/2023 - 02/2008
6	Cognitive Dysfunction 01/2024 - 09/2006
6	Onchocerciasis 03/2020 - 01/2017
5	Intestinal Volvulus (Volvulus) 05/2024 - 04/2016
5	Infections 05/2024 - 03/2019
4	Inflammation (Inflammations) 01/2024 - 01/2020
4	Acidosis 01/2023 - 09/2006
4	Epilepsy (Aura) 03/2020 - 01/2017
3	Neuroinflammatory Diseases 05/2024 - 04/2016
3	Neurologic Manifestations (Neurological Manifestations) 01/2021 - 02/2008
3	Acute Kidney Injury (Acute Renal Failure) 01/2020 - 10/2019
2	Status Epilepticus (Complex Partial Status Epilepticus) 05/2024 - 11/2010
2	Sickle Cell Anemia (Hemoglobin S Disease) 01/2024 - 07/2019
2	Stroke (Strokes) 01/2024 - 11/2023
2	Malnutrition (Nutritional Deficiencies) 01/2024 - 10/2019
2	Drug Resistant Epilepsy 01/2024 - 12/2021
2	Brain Injuries (Brain Injury) 11/2023 - 09/2006
2	Hemolysis 01/2020 - 01/2019
2	Fever (Fevers) 01/2019 - 07/2017
2	Central Nervous System Infections (Central Nervous System Infection) 01/2017 - 02/2008
2	Bacterial Meningitis 04/2010 - 01/2009
2	Traumatic Brain Injuries (Traumatic Brain Injury) 04/2010 - 01/2009
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2023
1	Cerebral Infarction 11/2023
1	Jaundice (Icterus) 01/2023
1	Atrophy 01/2023
1	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2022
1	Neoplasms (Cancer) 01/2022
1	Premature Birth (Birth, Premature) 11/2021
1	Muscle Spasticity (Spastic) 10/2021
1	Pain (Aches) 10/2021

Drug/Important Bio-Agent (IBA)

7	artenimol (dihydroartemisinin)IBA 01/2024 - 11/2018
7	piperaquineIBA 01/2024 - 11/2018
6	AntibodiesIBA 05/2024 - 04/2016
5	Doxycycline (Periostat)FDA LinkGeneric 05/2024 - 01/2018
5	Ivermectin (Mectizan)FDA Link 03/2020 - 01/2017
4	Proteins (Proteins, Gene)FDA Link 05/2024 - 04/2016
4	Hemoglobins (Hemoglobin)IBA 11/2023 - 01/2018
4	CytokinesIBA 01/2021 - 09/2006
4	Valproic Acid (Depakote)FDA LinkGeneric 01/2020 - 11/2014
3	Biomarkers (Surrogate Marker)IBA 01/2024 - 01/2023
3	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 01/2024 - 11/2018
3	Interleukin-10 (Interleukin 10)IBA 01/2021 - 09/2006
3	ChemokinesIBA 01/2021 - 09/2006
3	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 01/2017
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 09/2006
3	Erythropoietin FDA Link 01/2015 - 02/2008
2	AutoantibodiesIBA 05/2024 - 10/2019
2	pyrimethamine drug combination fanasil (Fansidar)FDA Link 01/2024 - 04/2023
2	KynurenineIBA 01/2023 - 01/2017
2	Angiopoietin-2IBA 01/2021 - 01/2020
2	Chemokine CCL5IBA 01/2021 - 09/2006
2	tau Proteins (tau Protein)IBA 01/2020 - 07/2007
2	Kynurenic Acid (Kynurenate)IBA 01/2020 - 01/2017
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2020 - 01/2019
2	Phenobarbital (Luminal)FDA Link 01/2020 - 02/2008
2	Antimalarials (Antimalarial Agents)IBA 07/2019 - 07/2017
2	IronIBA 11/2010 - 10/2008
2	Glycerol (Glycerine)FDA LinkGeneric 04/2010 - 01/2009
2	Mannitol (Osmitrol)FDA LinkGeneric 04/2010 - 01/2009
2	InterleukinsIBA 02/2008 - 09/2006
1	Anti-Bacterial Agents (Antibiotics)IBA 05/2024
1	LuciferasesIBA 05/2024
1	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2024
1	Monoclonal AntibodiesIBA 01/2024
1	Apolipoprotein E3IBA 11/2023
1	Apolipoproteins E (ApoE)IBA 11/2023
1	Apolipoprotein E4IBA 11/2023
1	NitrogenIBA 01/2023
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2023
1	Urea (Carbamide)FDA LinkGeneric 01/2023
1	ElectrolytesIBA 01/2023
1	Phosphopyruvate Hydratase (Enolase)IBA 01/2023
1	Amino Acids FDA Link 12/2022
1	ApolipoproteinsIBA 01/2022
1	Cytidine DeaminaseIBA 01/2022
1	EnzymesIBA 01/2022
1	Peptides (Polypeptides)IBA 01/2022
1	Messenger RNA (mRNA)IBA 01/2022
1	Inosine Diphosphate (IDP)IBA 11/2021
1	ArtesunateIBA 01/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	ArtemisininsIBA 01/2021
1	artemisinin (artemisinine)IBA 01/2021
1	Quinine (Quinson)FDA Link 01/2021
1	E-SelectinIBA 01/2020
1	BilirubinIBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020

Therapy/Procedure

10	Chemoprevention 01/2024 - 11/2018
7	Therapeutics 05/2024 - 02/2008
2	Blood Transfusion (Blood Transfusions) 09/2012 - 12/2008
1	Ketogenic Diet 01/2024
1	High-Protein Low-Carbohydrate Diet (Atkins Diet) 12/2021
1	Pain Management 10/2021
1	Injections 01/2021