John A Howe Selected Research

N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamide

1/2015	Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations.
9/2014	Clinical Implications of Detectable Baseline Hepatitis C Virus-Genotype 1 NS3/4A-Protease Variants on the Efficacy of Boceprevir Combined With Peginterferon/Ribavirin.
7/2013	Antiviral activity of boceprevir monotherapy in treatment-naive subjects with chronic hepatitis C genotype 2/3.
1/2013	Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-α2b and ribavirin in patients with chronic hepatitis C in the SPRINT-1 trial.
1/2013	Boceprevir with peginterferon alfa-2a-ribavirin is effective for previously treated chronic hepatitis C genotype 1 infection.

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John A Howe Research Topics

Disease

6	Infections 09/2014 - 12/2009
3	Chronic Hepatitis C 07/2013 - 01/2013
3	Neoplasms (Cancer) 10/2003 - 07/2002
2	Hepatitis C 01/2015 - 01/2013
1	Neutropenia 01/2013
1	Anemia 01/2013
1	Acquired Immunodeficiency Syndrome (AIDS) 06/2008
1	Carcinogenesis 10/2003

Drug/Important Bio-Agent (IBA)

5	N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA 01/2015 - 01/2013
3	Ribavirin (Virazole)FDA LinkGeneric 09/2014 - 01/2013
3	Antiviral Agents (Antivirals)IBA 07/2013 - 06/2008
1	Peptide Hydrolases (Proteases)FDA Link 01/2015
1	elbasvirIBA 03/2014
1	grazoprevirIBA 03/2014
1	Protease Inhibitors (Protease Inhibitor)IBA 03/2014
1	Amino Acids FDA Link 01/2013
1	peginterferon alfa-2b (Pegintron)FDA Link 01/2013
1	Hemoglobins (Hemoglobin)IBA 01/2013
1	LigandsIBA 12/2009
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2009
1	vicrivirocIBA 12/2009
1	HIV IntegraseIBA 06/2008
1	TensinsIBA 10/2003
1	beta-Galactosidase (Lactaid)IBA 10/2003
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2003
1	Phosphotransferases (Kinase)IBA 10/2003
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 10/2003
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 10/2003
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2003
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 07/2002
1	Drinking WaterIBA 07/2002
1	Doxycycline (Periostat)FDA LinkGeneric 07/2002
1	Interferon-alpha (Interferon Alfa)IBA 07/2002
1	Proteins (Proteins, Gene)FDA Link 07/2002

Therapy/Procedure

2	Therapeutics 03/2014 - 01/2013
1	Oncolytic Virotherapy 07/2003