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Tadashi Hisamitsu Selected Research

celastrol

12/2013Anti-invasive effects of celastrol in hypoxia-induced fibroblast-like synoviocyte through suppressing of HIF-1α/CXCR4 signaling pathway.
1/2013Celastrol inhibits lipopolysaccharide-stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of TLR4/NF-κB-mediated matrix metalloproteinase-9 expression.
12/2012Celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix metalloproteinase-9 expression.

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Tadashi Hisamitsu Research Topics

Disease

11Neoplasms (Cancer)
12/2018 - 01/2011
8Pain (Aches)
03/2024 - 10/2003
5Rheumatoid Arthritis
01/2020 - 03/2006
5Nasal Polyps (Nasal Polyp)
11/2004 - 06/2003
4Neoplasm Metastasis (Metastasis)
01/2017 - 01/2011
3Inflammation (Inflammations)
03/2024 - 02/2012
3Body Weight (Weight, Body)
03/2022 - 03/2003
3Experimental Melanoma
01/2017 - 01/2011
3Hypoxia (Hypoxemia)
12/2013 - 01/2013
3Experimental Arthritis
01/2013 - 02/2012
2Allergic Rhinitis
09/2022 - 07/2006
2Stomach Neoplasms (Stomach Cancer)
06/2017 - 05/2015
2Osteoarthritis
01/2017 - 03/2006
2Necrosis
01/2016 - 02/2014
2Osteoporosis
01/2016 - 11/2015
2Hyperplasia
01/2013 - 01/2013
1Rhinitis
09/2022
1Occupational Asthma
09/2022
1Asthma (Bronchial Asthma)
09/2022
1Anemia
03/2022
1Sleep Initiation and Maintenance Disorders (Insomnia)
03/2022
1Atrophy
04/2021
1Weight Gain
04/2021
1Mucositis
12/2018
1Stomatitis
12/2018
1Aphthous Stomatitis (Aphthous Ulcer)
12/2018
1Trigeminal Neuralgia (Tic Douloureux)
06/2018
1Headache (Headaches)
06/2018
1Postherpetic Neuralgia
06/2018
1Fibromyalgia (Fibrositis)
06/2018
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2018
1Knee Osteoarthritis
01/2017
1Postmenopausal Osteoporosis
01/2017
1Hepatocellular Carcinoma (Hepatoma)
11/2016
1Carcinogenesis
11/2016
1Colorectal Neoplasms (Colorectal Cancer)
11/2016
1Chronic Pain
03/2016
1Bone Resorption
01/2016
1Ischemia
02/2015
1Retinal Neovascularization
09/2014

Drug/Important Bio-Agent (IBA)

6Matrix Metalloproteinases (MMPs)IBA
02/2014 - 10/2004
4Analgesics (Analgesic Drugs)IBA
03/2024 - 06/2018
4juzentaihotoIBA
12/2018 - 01/2011
3Plant ExtractsIBA
09/2022 - 01/2012
3CorticosteroneIBA
03/2022 - 02/2012
3Yi-Gan SanIBA
06/2021 - 03/2016
3Morphine (MS Contin)FDA LinkGeneric
06/2018 - 03/2011
3ethyl acetateIBA
02/2018 - 11/2016
3PeriostinIBA
01/2017 - 01/2017
3CytokinesIBA
01/2017 - 06/2003
3Proteins (Proteins, Gene)FDA Link
02/2015 - 12/2013
3celastrolIBA
12/2013 - 12/2012
3Fluticasone (Cutivate)FDA LinkGeneric
07/2006 - 10/2004
2Formaldehyde (Formol)FDA Link
03/2024 - 06/2021
2palmatineIBA
01/2016 - 11/2015
2VimentinIBA
05/2015 - 02/2015
2Messenger RNA (mRNA)IBA
11/2014 - 12/2013
2Metalloproteases (Metalloproteinases)IBA
02/2014 - 07/2006
2Small Interfering RNA (siRNA)IBA
03/2013 - 01/2013
2Interleukin-17 (Interleukin 17)IBA
03/2013 - 12/2012
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2012 - 11/2004
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2006 - 10/2004
2Anti-Bacterial Agents (Antibiotics)IBA
12/2003 - 06/2003
2MacrolidesIBA
12/2003 - 06/2003
1Interleukin-33IBA
09/2022
1Toluene 2,4-Diisocyanate (Toluene Diisocyanate)IBA
09/2022
1sho-seiryu-toIBA
09/2022
1kamikihi-to (KKT)IBA
03/2022
1Protein Kinases (Protein Kinase)IBA
06/2021
1MicroRNAs (MicroRNA)IBA
01/2020
1pyruvate dehydrogenase kinase 4IBA
01/2020
1bu-zhong-yi-qi-tangIBA
12/2018
1Therapeutic UsesIBA
02/2018
1Biomarkers (Surrogate Marker)IBA
01/2017
1Interleukin-13IBA
01/2017
1Semaphorin-3AIBA
01/2017
1QuercetinIBA
11/2016
1Opioid Analgesics (Opioids)IBA
03/2016
1BerberineIBA
01/2016
1Antineoplastic Agents (Antineoplastics)IBA
05/2015
1Cadherins (E-Cadherin)IBA
05/2015
1Connexin 43 (Connexin43)IBA
02/2015
1ConnexinsIBA
02/2015
1Nerve Growth Factor (NGF)IBA
02/2015
1salicylhydroxamic acid (SHAM)IBA
02/2015
1Norepinephrine (Noradrenaline)FDA LinkGeneric
02/2015
1Retinaldehyde (Retinal)IBA
09/2014
1Apyrase (ATP Diphosphatase)IBA
09/2014
1NF-kappa B (NF-kB)IBA
02/2014

Therapy/Procedure

7Kampo Medicine (Kampo)
09/2022 - 01/2011
6Therapeutics
06/2021 - 01/2011
2Oral Administration
01/2012 - 01/2011
2Intravenous Injections
01/2012 - 01/2011
1Transcutaneous Electric Nerve Stimulation (TENS)
03/2024
1Electroacupuncture
06/2021
1Radiotherapy
12/2018
1Drug Therapy (Chemotherapy)
12/2018
1Chinese Traditional Medicine (Traditional Chinese Medicine)
06/2017
1Immunotherapy
01/2017
1Liver Transplantation
11/2016