Takatsugu Hirokawa Selected Research

Zanamivir (Relenza)

10/2011

Correlation analyses on binding affinity of sialic acid analogues and anti-influenza drugs with human neuraminidase using ab initio MO calculations on their complex structures--LERE-QSAR analysis (IV).

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Takatsugu Hirokawa Research Topics

Disease

5	Neoplasms (Cancer) 12/2022 - 08/2009
3	Parkinsonian Disorders (Parkinsonism) 10/2015 - 04/2003
2	Human Influenza (Influenza) 10/2023 - 10/2011
2	Adenocarcinoma of Lung 04/2022 - 01/2019
2	Fibrosis (Cirrhosis) 01/2022 - 12/2017
2	COVID-19 01/2022 - 04/2021
2	Parkinson Disease (Parkinson's Disease) 11/2021 - 04/2003
2	GM2 Gangliosidoses (GM2 Gangliosidosis) 09/2016 - 01/2016
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 09/2016 - 01/2016
1	Sphingolipidoses (Sphingolipidosis) 11/2023
1	Neuroinflammatory Diseases 11/2023
1	Immune System Diseases (Immune Disorders) 12/2022
1	Mental Disorders (Mental Disorder) 12/2022
1	Infections 01/2022
1	Inflammation (Inflammations) 01/2022
1	Yellow Fever 01/2022
1	Pancreatic Neoplasms (Pancreatic Cancer) 12/2020
1	Lung Neoplasms (Lung Cancer) 12/2020
1	Adenocarcinoma 01/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2019
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2018
1	Leukemia 12/2016
1	Syncope (Fainting) 01/2015
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 11/2014
1	Neuraminidase deficiency with beta-galactosidase deficiency 11/2009
1	Carcinogenesis 08/2009
1	Intestinal Neoplasms (Intestinal Cancer) 08/2009
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 08/2009

Drug/Important Bio-Agent (IBA)

3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019 - 08/2009
2	MethyltransferasesIBA 10/2023 - 01/2022
2	Proteins (Proteins, Gene)FDA Link 04/2022 - 11/2021
2	Antiviral Agents (Antivirals)IBA 01/2022 - 04/2021
2	Peptides (Polypeptides)IBA 12/2020 - 01/2018
2	Hexosaminidase BIBA 09/2016 - 01/2016
1	GlycosphingolipidsIBA 11/2023
1	RNA (Ribonucleic Acid)IBA 10/2023
1	Type II Vasoactive Intestinal Peptide ReceptorsIBA 12/2022
1	SteroidsIBA 01/2022
1	3-deazaneplanocinIBA 01/2022
1	AdenosylhomocysteinaseIBA 01/2022
1	daidzeinIBA 01/2022
1	EcdysoneIBA 01/2022
1	EnzymesIBA 01/2022
1	FlavonoidsIBA 01/2022
1	Glutathione Transferase (Glutathione S-Transferase)IBA 01/2022
1	Hormones (Hormone)IBA 01/2022
1	Gemcitabine FDA Link 12/2020
1	KS-58IBA 12/2020
1	Prostaglandin E Receptors (Prostaglandin E Receptor)IBA 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Antineoplastic Agents (Antineoplastics)IBA 01/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019
1	Aprepitant (Emend)FDA Link 01/2019
1	TicagrelorIBA 01/2019
1	OrexinsIBA 01/2018
1	Molecular Chaperones (Chaperone, Molecular)IBA 12/2017
1	CollagenIBA 12/2017
1	DNA (Deoxyribonucleic Acid)IBA 12/2016
1	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 12/2016
1	Hexosaminidases (Hexosaminidase)IBA 09/2016
1	G(M2) Activator ProteinIBA 09/2016
1	Mannose (D-Mannose)IBA 01/2016
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2016
1	Hexosaminidase A (Hex A)IBA 01/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2015
1	Ataxin-3IBA 11/2014
1	Deubiquitinating EnzymesIBA 11/2014
1	PTEN-induced putative kinaseIBA 06/2014
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 10/2011
1	Neuraminidase (Sialidase)IBA 10/2011
1	Oseltamivir (Tamiflu)FDA Link 10/2011
1	Zanamivir (Relenza)FDA Link 10/2011
1	Enzyme Precursors (Zymogens)IBA 11/2009
1	GlucosinolatesIBA 08/2009
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 08/2009
1	XenobioticsIBA 08/2009
1	beta CateninIBA 08/2009
1	LigandsIBA 08/2009
1	Tryptophan (L-Tryptophan)FDA Link 08/2009
1	indoleIBA 08/2009
1	HydrolasesIBA 04/2003
1	UbiquitinIBA 04/2003

Therapy/Procedure

2	Therapeutics 09/2016 - 01/2016
1	Drug Therapy (Chemotherapy) 12/2020
1	Intravenous Injections 12/2020
1	Oral Administration 01/2019
1	Enzyme Replacement Therapy 01/2016
1	Chemoprevention 08/2009