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Hajime Higuchi Selected Research

Hepatocellular Carcinoma (Hepatoma)

6/2010DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.
9/2006Cyclooxygenase-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo.

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Hajime Higuchi Research Topics

Disease

11Neoplasms (Cancer)
02/2019 - 03/2002
7Pancreatic Neoplasms (Pancreatic Cancer)
10/2022 - 06/2009
6Cholangiocarcinoma
11/2006 - 03/2002
5Inflammation (Inflammations)
04/2013 - 03/2002
4Cholestasis
07/2003 - 11/2002
3Lymphatic Metastasis
01/2013 - 07/2011
3Carcinogenesis
04/2012 - 04/2002
2Colonic Neoplasms (Colon Cancer)
02/2019 - 04/2002
2Esophageal Neoplasms (Esophageal Cancer)
07/2018 - 07/2011
2Disease Progression
07/2018 - 01/2013
2Hypersensitivity (Allergy)
07/2018 - 04/2015
2Neoplasm Metastasis (Metastasis)
04/2015 - 01/2013
2Colorectal Neoplasms (Colorectal Cancer)
02/2014 - 04/2012
2Carcinoma (Carcinomatosis)
01/2013 - 08/2005
2Stomach Neoplasms (Stomach Cancer)
01/2013 - 08/2005
2Hepatocellular Carcinoma (Hepatoma)
06/2010 - 09/2006
2Fibrosis (Cirrhosis)
11/2003 - 07/2003
1Diarrhea
02/2019
1Hyperbilirubinemia
02/2019
1Sigmoid Neoplasms
02/2019
1Thrombocytopenia (Thrombopenia)
02/2019
1Squamous Cell Neoplasms (Squamous Cell Cancer)
07/2018
1Adenoma (Adenomas)
09/2015
1Type 3 Maturity-Onset Diabetes of the Young
01/2015
1Pancreatitis
04/2013
1Chronic Pancreatitis
04/2013
1Hyperglycemia
04/2013
1Adenocarcinoma
09/2012
1Hemobilia
06/2012
1Hemorrhage
06/2012
1Necrosis
06/2012
1Gastrinoma
06/2012
1Gallbladder Neoplasms (Gallbladder Cancer)
07/2011
1Crohn Disease (Crohn's Disease)
07/2008
1Ulcerative Colitis
07/2008
1Microscopic Colitis
01/2007
1Hypoalbuminemia
01/2007
1Granuloma
01/2007

Drug/Important Bio-Agent (IBA)

4GemcitabineFDA Link
10/2022 - 11/2010
4EnzymesIBA
07/2018 - 04/2002
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2004 - 09/2002
4Bile Acids and Salts (Bile Acids)IBA
07/2003 - 04/2002
3InterferonsIBA
07/2018 - 09/2006
3Death Domain ReceptorsIBA
11/2003 - 05/2003
2Peptides (Polypeptides)IBA
07/2018 - 04/2015
2C-Reactive ProteinIBA
04/2015 - 01/2007
2Proteins (Proteins, Gene)FDA Link
01/2013 - 11/2002
2Irinotecan (Camptosar)FDA LinkGeneric
01/2013 - 08/2005
2Cisplatin (Platino)FDA LinkGeneric
01/2013 - 07/2011
2Fluorouracil (Carac)FDA LinkGeneric
09/2012 - 07/2011
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
04/2012 - 04/2002
2DNA (Deoxyribonucleic Acid)IBA
06/2010 - 09/2002
2LigandsIBA
05/2004 - 11/2002
2ErbB Receptors (EGF Receptor)IBA
11/2002 - 04/2002
1130-nm albumin-bound paclitaxelIBA
10/2022
1Oxaliplatin (Eloxatin)FDA LinkGeneric
02/2019
1Bevacizumab (Avastin)FDA Link
02/2019
1Docetaxel (Taxotere)FDA Link
07/2018
1Immunologic Factors (Immunomodulators)IBA
04/2015
1Interleukin-8 (Interleukin 8)IBA
04/2015
1Hepatocyte Nuclear FactorsIBA
01/2015
1Complementary DNA (cDNA)IBA
02/2014
1Insulin (Novolin)FDA Link
04/2013
1Glucagon-Like Peptide-1 ReceptorIBA
04/2013
1CCR2 ReceptorsIBA
04/2013
1Glucagon-Like Peptide 1 (GLP 1)IBA
04/2013
1CeruletideIBA
04/2013
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
04/2013
1Small Interfering RNA (siRNA)IBA
02/2013
1Cadherins (E-Cadherin)IBA
02/2013
1Jagged-1 ProteinIBA
02/2013
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
02/2013
1pro-gastrin-releasing peptide (31-98)IBA
01/2013
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
07/2012
1Transforming Growth Factors (Transforming Growth Factor)IBA
07/2012
1GastrinsIBA
06/2012
1Bile Pigments (Bilin)IBA
06/2012
1Bacterial AntigensIBA
06/2012
1SecretagoguesIBA
06/2012
1Interleukin-12 (IL 12)IBA
06/2012
1Mesalamine (Mesalazine)FDA LinkGeneric
04/2012
1Dinoprostone (PGE2)FDA Link
04/2012
115-hydroxyprostaglandin dehydrogenaseIBA
04/2012
1MethyltransferasesIBA
06/2010
1Caspase 8 (Caspase-8)IBA
06/2010
1Transforming Growth Factor beta (TGF-beta)IBA
06/2009
116S Ribosomal RNAIBA
07/2008
1Immunoglobulin G (IgG)IBA
01/2007
1SteroidsIBA
01/2007
1Interferon-betaIBA
09/2006

Therapy/Procedure

9Drug Therapy (Chemotherapy)
02/2019 - 08/2005
7Therapeutics
07/2018 - 05/2004
1Colectomy
02/2019
1Maintenance Chemotherapy
02/2019
1Surgical Instruments (Clip)
09/2015
1Endoscopic Sphincterotomy
07/2015
1Transplantation
09/2012
1Pancreaticoduodenectomy
06/2012
1Endoscopic Hemostasis
06/2012
1Aftercare (After-Treatment)
09/2006