Simon Heidegger Selected Research

RNA (Ribonucleic Acid)

1/2023	Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy.
1/2021	Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
1/2019	RIG-I activation is critical for responsiveness to checkpoint blockade.
1/2019	Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines.
11/2015	TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection.
11/2010	Delivery of immunostimulatory RNA oligonucleotides by gelatin nanoparticles triggers an efficient antitumoral response.

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Simon Heidegger Research Topics

Disease

13	Neoplasms (Cancer) 01/2024 - 11/2010
5	Melanoma (Melanoma, Malignant) 01/2023 - 01/2019
5	Graft vs Host Disease (Graft-Versus-Host Disease) 10/2019 - 01/2014
3	Infections 11/2015 - 05/2013
2	Lymphoma (Lymphomas) 01/2024 - 01/2014
2	Inflammation (Inflammations) 01/2017 - 11/2015
1	T-Cell Lymphoma (Lymphoma, T Cell) 01/2024
1	Dysbiosis 11/2023
1	Vesicular Stomatitis 09/2023
1	Body Weight (Weight, Body) 01/2021
1	Progressive Multifocal Leukoencephalopathy 01/2021
1	Bites and Stings (Sting) 01/2017
1	Virus Diseases (Viral Diseases) 11/2015
1	Mycoplasma Infections 01/2015
1	Leukemia 01/2014
1	Cytokine Release Syndrome 01/2014
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2014
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2014
1	Hematologic Neoplasms (Hematological Malignancy) 01/2014
1	B-Cell Lymphoma (Lymphoma, B Cell) 08/2013
1	Lung Neoplasms (Lung Cancer) 08/2013
1	Carcinoma (Carcinomatosis) 08/2013

Drug/Important Bio-Agent (IBA)

6	RNA (Ribonucleic Acid)IBA 01/2023 - 11/2010
5	Immune Checkpoint InhibitorsIBA 11/2023 - 01/2021
3	AntigensIBA 01/2023 - 01/2019
3	Interferon Type IIBA 01/2021 - 01/2019
3	Neoplasm Antigens (Tumor Antigens)IBA 01/2021 - 01/2019
3	Pattern Recognition ReceptorsIBA 01/2019 - 01/2014
2	Proteins (Proteins, Gene)FDA Link 09/2023 - 08/2011
2	InterferonsIBA 01/2023 - 01/2017
2	VaccinesIBA 03/2019 - 01/2019
1	68Ga-pentixaforIBA 01/2024
1	Chemokine ReceptorsIBA 01/2024
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2023
1	phloretic acidIBA 11/2023
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 09/2023
1	Viral RNAIBA 09/2023
1	GTP Phosphohydrolases (GTPases)IBA 01/2023
1	Nucleic AcidsIBA 01/2023
1	Therapeutic UsesIBA 01/2021
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2021
1	Azacitidine (5 Azacytidine)FDA Link 01/2021
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2021
1	pembrolizumabIBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 01/2019
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2019
1	CaspasesIBA 01/2017
1	Poly I-CIBA 11/2015
1	Antiviral Agents (Antivirals)IBA 11/2015
1	Chloroquine (Aralen)FDA LinkGeneric 01/2015
1	Peptide Hydrolases (Proteases)FDA Link 01/2015
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2014
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2014
1	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2014
1	Cisplatin (Platino)FDA LinkGeneric 01/2014
1	CytokinesIBA 01/2014
1	Brentuximab VedotinIBA 01/2014
1	Immunoconjugates (Immunoconjugate)IBA 01/2014
1	Anaplastic Lymphoma KinaseIBA 01/2014
1	NLR ProteinsIBA 01/2014
1	Pathogen-Associated Molecular Pattern MoleculesIBA 10/2013
1	Interleukin-22 (IL-22)IBA 08/2013
1	Carboplatin (JM8)FDA LinkGeneric 08/2013
1	interleukin-22 receptor (IL-22R)IBA 08/2013
1	IntegrinsIBA 05/2013
1	Toll-Like Receptor 7IBA 08/2011
1	Interleukin-1 Receptor-Associated KinasesIBA 08/2011

Therapy/Procedure

8	Therapeutics 01/2024 - 08/2011
6	Immunotherapy 11/2023 - 08/2011
5	Hematopoietic Stem Cell Transplantation 10/2019 - 01/2014
2	Drug Therapy (Chemotherapy) 01/2021 - 08/2013
1	Precision Medicine 01/2024
1	Salvage Therapy 01/2014
1	Stem Cell Transplantation 01/2014
1	Injections 08/2011