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Daniel A Harrington Selected Research

Erectile Dysfunction

3/2024SHH regulates penile morphology and smooth muscle through a mechanism involving BMP4 and GREM1.
3/2024BMP4 and GREM1 are targets of SHH signaling and downstream regulators of collagen in the penis.
1/2022Sonic Hedgehog Signaling in Primary Culture of Human Corpora Cavernosal Tissue From Prostatectomy, Diabetic, and Peyronie's Patients.
10/2021Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction.
1/2021Caspase Signaling in ED Patients and Animal Models.
10/2018Peptide amphiphile delivery of sonic hedgehog protein promotes neurite formation in penile projecting neurons.
1/2017Peptide amphiphile nanofiber hydrogel delivery of sonic hedgehog protein to the cavernous nerve to promote regeneration and prevent erectile dysfunction.
3/2016Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction.
2/2011Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers.
1/2011Peptide amphiphile nanofiber delivery of sonic hedgehog protein to reduce smooth muscle apoptosis in the penis after cavernous nerve resection.

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Daniel A Harrington Research Topics

Disease

10Erectile Dysfunction
03/2024 - 01/2011
10Neoplasms (Cancer)
10/2019 - 12/2012
6Prostatic Neoplasms (Prostate Cancer)
01/2023 - 01/2011
3Fibrosis (Cirrhosis)
03/2024 - 03/2016
3Xerostomia
11/2023 - 07/2013
2Hypertension (High Blood Pressure)
03/2024 - 01/2022
2Neoplasm Metastasis (Metastasis)
10/2019 - 01/2018
1Penile Induration (Peyronie's Disease)
03/2024
1Squamous Cell Carcinoma of Head and Neck
11/2023
1Cardiovascular Diseases (Cardiovascular Disease)
01/2022
1Smear Layer
02/2021
1Osteolysis
01/2020
1Renal Cell Carcinoma (Grawitz Tumor)
01/2020
1Breast Neoplasms (Breast Cancer)
10/2019
1Stress Urinary Incontinence
11/2018
1Bone Diseases (Bone Disease)
01/2018
1Infections
01/2017
1Head and Neck Neoplasms (Head and Neck Cancer)
01/2017
1Peripheral Nerve Injuries
03/2016
1Endometrial Neoplasms (Endometrial Cancer)
08/2015
1Inflammation (Inflammations)
02/2014
1Neurogenic Urinary Bladder (Bladder, Neurogenic)
10/2005

Drug/Important Bio-Agent (IBA)

12HydrogelsIBA
01/2023 - 12/2012
5Peptides (Polypeptides)IBA
01/2022 - 02/2011
4CollagenIBA
03/2024 - 03/2016
3Hyaluronic Acid (Hyaluronan)IBA
08/2015 - 12/2012
2Hedgehog ProteinsIBA
10/2021 - 01/2017
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2019 - 12/2012
2perlecanIBA
10/2019 - 01/2018
2Proteoglycans (Proteoglycan)IBA
10/2019 - 01/2018
1Neurotransmitter Agents (Neurotransmitter)IBA
03/2024
1Proteins (Proteins, Gene)FDA Link
01/2022
1SilverIBA
02/2021
1cabozantinibIBA
01/2020
1DNA (Deoxyribonucleic Acid)IBA
01/2018
1Heparitin Sulfate (Heparan Sulfate)IBA
01/2018
1RNA (Ribonucleic Acid)IBA
01/2018
1Matrix Metalloproteinases (MMPs)IBA
01/2018
1Matrix Metalloproteinase 7 (Matrilysin)IBA
01/2018
1Semaphorin-3AIBA
01/2018
1Fibroblast Growth Factors (Fibroblast Growth Factor)IBA
01/2016
1PlasticsIBA
08/2015
1Androgen Receptors (Androgen Receptor)IBA
07/2014
1Doxorubicin (Adriamycin)FDA LinkGeneric
03/2014
1PolymersIBA
03/2014
1AntibodiesIBA
10/2005
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
10/2005

Therapy/Procedure

9Prostatectomy (Retropubic Prostatectomy)
03/2024 - 01/2011
5Therapeutics
03/2024 - 03/2014
3Radiotherapy
11/2023 - 07/2013
1Denervation
03/2024
1Palliative Care (Palliative Therapy)
11/2023
1Tooth Preparation
02/2021
1Laser Therapy (Surgery, Laser)
02/2021
1Aftercare (After-Treatment)
10/2005