Hiromichi Hara Selected Research

Fibrosis (Cirrhosis)

1/2021	Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk.
10/2019	Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis.
8/2017	Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.
1/2017	Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy.
1/2016	Metformin attenuates lung fibrosis development via NOX4 suppression.
1/2016	Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.

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Hiromichi Hara Research Topics

Disease

14	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 03/2012
8	Asthma (Bronchial Asthma) 06/2022 - 01/2017
6	Fibrosis (Cirrhosis) 01/2021 - 01/2016
5	Lung Diseases (Lung Disease) 01/2023 - 07/2011
5	Interstitial Lung Diseases (Interstitial Lung Disease) 06/2021 - 11/2005
4	Idiopathic Pulmonary Fibrosis 11/2021 - 01/2016
4	Neoplasms (Cancer) 11/2020 - 01/2014
3	Infections 11/2015 - 06/2008
2	Respiratory Insufficiency (Respiratory Failure) 10/2020 - 01/2014
2	Bronchiectasis 10/2020 - 11/2005
2	Adenocarcinoma of Lung 06/2019 - 01/2014
2	Tuberculosis (Tuberculoses) 01/2017 - 10/2003
2	Starvation 01/2013 - 08/2006
1	Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis) 01/2023
1	Sinusitis 06/2022
1	Inflammation (Inflammations) 01/2022
1	Eosinophilia 01/2022
1	Atrophy 01/2022
1	Sarcopenia 01/2022
1	Conjunctivitis 01/2022
1	Respiratory Sounds (Crackle) 01/2022
1	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 01/2022
1	Psoriasis (Pustulosis Palmaris et Plantaris) 06/2021
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2021
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2020
1	Pneumonia (Pneumonitis) 10/2020
1	Amyopathic dermatomyositis 10/2020
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/2020
1	Necrosis 01/2020
1	Rhinosinusitis 10/2019
1	Neoplasm Metastasis (Metastasis) 06/2019
1	Lung Neoplasms (Lung Cancer) 06/2019
1	Carcinoma (Carcinomatosis) 06/2019
1	Rheumatoid Arthritis 01/2019
1	Alzheimer Disease (Alzheimer's Disease) 01/2019
1	Nephrotic Syndrome (Syndrome, Nephrotic) 02/2018
1	Aortic Rupture 01/2018

Drug/Important Bio-Agent (IBA)

10	SmokeIBA 01/2022 - 03/2012
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2012
6	Bleomycin (Blenoxane)FDA LinkGeneric 01/2021 - 01/2016
5	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 01/2018
5	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2013
4	Monoclonal AntibodiesIBA 01/2022 - 10/2019
3	InterleukinsIBA 01/2022 - 01/2019
3	benralizumabIBA 01/2022 - 08/2020
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2007
3	pirfenidoneIBA 11/2021 - 01/2017
3	Phosphotransferases (Kinase)IBA 01/2020 - 01/2019
3	Sirolimus (Rapamycin)FDA Link 01/2019 - 01/2015
2	dupilumabIBA 06/2022 - 01/2022
2	mepolizumabIBA 08/2020 - 10/2019
2	IronIBA 01/2020 - 01/2019
2	11 alpha- hydroxy- 9,15- dioxo- 2,3,4,5,20- pentanor- 19- carboxyprostanoic acidIBA 06/2019 - 01/2017
2	ProstaglandinsIBA 06/2019 - 01/2017
2	Azithromycin (Zithromax)FDA LinkGeneric 02/2018 - 08/2017
1	Minoxidil (Rogaine)FDA LinkGeneric 01/2023
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 01/2022
1	Interleukin-13IBA 01/2022
1	Interleukin-4 (Interleukin 4)IBA 01/2022
1	nintedanibIBA 11/2021
1	LipofuscinIBA 01/2021
1	Galectin 3 (LGALS3)IBA 01/2021
1	CateninsIBA 01/2021
1	Cisplatin (Platino)FDA LinkGeneric 11/2020
1	PlatinumIBA 11/2020
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/2020
1	SteroidsIBA 10/2020
1	Tacrolimus (Prograf)FDA LinkGeneric 10/2020
1	Immune Checkpoint InhibitorsIBA 10/2020
1	pembrolizumabIBA 10/2020
1	Methylprednisolone FDA LinkGeneric 10/2020
1	Dasatinib (BMS 354825)FDA Link 09/2020
1	LipidsIBA 01/2020
1	CaspasesIBA 01/2020
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA 10/2019
1	Indicators and Reagents (Reagents)IBA 06/2019
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 06/2019
1	AntigensIBA 06/2019
1	Tumor Biomarkers (Tumor Markers)IBA 06/2019
1	LipopolysaccharidesIBA 01/2019
1	LigandsIBA 01/2019
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2019
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2019
1	GalactosidasesIBA 01/2019
1	CalciumIBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2019
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2019
1	ChemokinesIBA 01/2019
1	Cyclin-Dependent Kinase Inhibitor p16IBA 01/2019
1	8-Hydroxy-2'-DeoxyguanosineIBA 01/2019
1	Lamin Type B (Lamin B)IBA 01/2019
1	TensinsIBA 01/2019
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 01/2019
1	PTEN-induced putative kinaseIBA 01/2019

Therapy/Procedure

5	Therapeutics 11/2021 - 01/2014
2	Traction 10/2020 - 11/2005
1	Biological Therapy 01/2021