Harald Hübner Selected Research

Pergolide (Permax)

7/2011	The bulky N6 substituent of cabergoline is responsible for agonism of this drug at 5-hydroxytryptamine 5-HT2A and 5-HT2B receptors and thus is a determinant of valvular heart disease.
3/2008	Characterization of the molecular fragment that is responsible for agonism of pergolide at serotonin 5-Hydroxytryptamine2B and 5-Hydroxytryptamine2A receptors.

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Harald Hübner Research Topics

Disease

10	Neoplasms (Cancer) 01/2024 - 08/2010
8	Pain (Aches) 05/2024 - 04/2011
8	Schizophrenia (Dementia Praecox) 12/2020 - 08/2004
4	Parkinson Disease (Parkinson's Disease) 06/2023 - 07/2011
3	Chronic Obstructive Pulmonary Disease (COPD) 01/2024 - 11/2018
2	Asthma (Bronchial Asthma) 01/2024 - 01/2020
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 01/2021
2	Mental Disorders (Mental Disorder) 12/2020 - 04/2011
2	Nervous System Diseases (Neurological Disorders) 01/2020 - 10/2017
2	Breast Neoplasms (Breast Cancer) 03/2017 - 07/2015
2	Substance-Related Disorders (Drug Abuse) 01/2017 - 05/2008
1	Heart Failure 03/2024
1	Heart Diseases (Heart Disease) 01/2024
1	Alcoholism (Alcohol Abuse) 01/2023
1	Central Nervous System Diseases (CNS Diseases) 01/2021
1	Psychotic Disorders (Schizoaffective Disorder) 01/2021
1	Cardiomegaly (Heart Hypertrophy) 01/2021
1	Urinary Incontinence 01/2020
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2020
1	Fatigue 09/2017
1	Adenocarcinoma 03/2017
1	Prostatic Neoplasms (Prostate Cancer) 03/2017
1	Respiratory Insufficiency (Respiratory Failure) 01/2016
1	Carcinoma (Carcinomatosis) 01/2016
1	Neuralgia (Stump Neuralgia) 10/2014
1	Erectile Dysfunction 12/2012
1	Heart Valve Diseases (Valvular Heart Disease) 07/2011
1	Vascular Ring 03/2008
1	Catalepsy 08/2004

Drug/Important Bio-Agent (IBA)

8	Neurotensin Receptors (Neurotensin Receptor)IBA 03/2017 - 08/2010
7	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 08/2004
6	LigandsIBA 05/2024 - 05/2011
5	Antipsychotic Agents (Antipsychotics)IBA 01/2017 - 08/2004
4	NeurotensinIBA 06/2023 - 05/2011
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2011
3	Analgesics (Analgesic Drugs)IBA 01/2022 - 01/2016
3	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 01/2021 - 06/2014
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 06/2020 - 05/2011
3	Opioid Receptors (Opioid Receptor)IBA 01/2020 - 01/2016
3	Opioid Analgesics (Opioids)IBA 01/2017 - 10/2014
2	Amphetamine (Amfetamine)FDA LinkGeneric 01/2021 - 08/2004
2	Dopamine D4 Receptors (Dopamine D4 Receptor)IBA 01/2021 - 08/2004
2	ORALIT (ORS)IBA 01/2020 - 01/2020
2	Dopamine D3 ReceptorsIBA 01/2017 - 05/2008
2	2- (4- (4- chlorophenyl)piperazin- 1- ylmethyl)pyrazolo(1,5- a)- pyridineIBA 01/2017 - 08/2004
2	Peptides (Polypeptides)IBA 01/2016 - 08/2010
2	Molecular Probes (Molecular Probe)IBA 01/2016 - 01/2013
2	Pergolide (Permax)FDA Link 07/2011 - 03/2008
1	Protein Isoforms (Isoforms)IBA 03/2024
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2024
1	Neurotransmitter Agents (Neurotransmitter)IBA 06/2023
1	hordenineIBA 01/2023
1	Non-Narcotic Analgesics (Analgesics, Non Narcotic)IBA 01/2022
1	Dexmedetomidine FDA Link 01/2022
1	Adenosine Monophosphate (AMP)IBA 01/2021
1	PAR-2 ReceptorIBA 06/2020
1	OrexinsIBA 01/2020
1	suvorexantIBA 01/2020
1	Orexin Receptor AntagonistsIBA 01/2020
1	Muscarinic M3 ReceptorIBA 01/2020
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 11/2018
1	SolventsIBA 09/2017
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2017
1	Dopamine Receptors (Dopamine Receptor)IBA 12/2016
1	AlkaloidsIBA 01/2016
1	ArrestinIBA 01/2016
1	Morphine (MS Contin)FDA LinkGeneric 01/2016
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 04/2014
1	GlycoconjugatesIBA 11/2013
1	SR 142948AIBA 11/2013
1	PalladiumIBA 11/2013
1	azuleneIBA 12/2012
1	Serotonin (5 Hydroxytryptamine)IBA 07/2011
1	Dopamine Agonists (Dopamine Agonist)IBA 07/2011
1	Cabergoline FDA LinkGeneric 07/2011
1	neurotensin (9-13)IBA 05/2011
1	PeptoidsIBA 08/2010
1	Apomorphine FDA Link 08/2004

Therapy/Procedure

3	Therapeutics 05/2024 - 05/2011
1	Analgesia 01/2016
1	Radiotherapy 04/2014
1	Aftercare (After-Treatment) 04/2014