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J M Gutiérrez Selected Research

Edema (Dropsy)

6/2006Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice.
10/2003Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom.
10/2002Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms.
9/2001Effects of chemical modifications of crotoxin B, the phospholipase A(2) subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities.
6/2001Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom.
6/2001Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms.
4/2001Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage.
3/2001Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom.
2/2001The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms.
11/2000Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.
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J M Gutiérrez Research Topics

Disease

16Edema (Dropsy)
06/2006 - 01/2000
9Hemorrhage
03/2011 - 01/2000
6Myotoxicity
09/2008 - 08/2000
3Snake Bites (Snake Bite)
09/2014 - 09/2000
3Hyperalgesia
05/2003 - 08/2001
2Pain (Aches)
01/2021 - 02/2001
2Necrosis
02/2001 - 08/2000
1Fibromyalgia (Fibrositis)
10/2020
1Vesico-Ureteral Reflux (Vesicoureteral Reflux)
07/2014
1Urinary Tract Infections (Urinary Tract Infection)
07/2014
1Ureterocele
07/2014
1Neoplasms (Cancer)
03/2011
1Hydrocephalus (Hydrocephaly)
03/2011
1Infections
03/2011
1Arthritis (Polyarthritis)
08/2007
1Arthralgia (Joint Pain)
08/2007
1Wounds and Injuries (Trauma)
12/2001
1Hemolysis
07/2001
1Thrombocytopenia (Thrombopenia)
04/2001
1Ischemia
09/2000
1Fibrosis (Cirrhosis)
09/2000
1Gas Gangrene (Gangrene, Gas)
08/2000
1Bites and Stings (Sting)
07/2000

Drug/Important Bio-Agent (IBA)

16VenomsIBA
01/2021 - 02/2000
10Snake Venoms (Snake Venom)IBA
07/2013 - 02/2000
4Antivenins (Antivenoms)IBA
07/2013 - 02/2000
4Metalloproteases (Metalloproteinases)IBA
04/2001 - 07/2000
4Liposomes (Liposome)IBA
03/2001 - 01/2000
3Phospholipases A2 (Phospholipase A2)IBA
01/2021 - 03/2001
3AntibodiesIBA
10/2003 - 10/2002
3Phospholipases (Phospholipase)IBA
08/2001 - 02/2001
2Proteins (Proteins, Gene)FDA Link
01/2021 - 05/2003
2Matrix Metalloproteinases (MMPs)IBA
08/2007 - 09/2000
2Immunoglobulin G (IgG)IBA
10/2003 - 02/2000
2icatibantIBA
05/2003 - 08/2001
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2003 - 09/2000
2BradykininIBA
05/2003 - 08/2001
22,5-dichloro-4-bromophenol (B 2)IBA
05/2003 - 08/2001
2AnticoagulantsIBA
09/2001 - 03/2001
2CoagulantsIBA
06/2001 - 02/2001
2NeurotoxinsIBA
03/2001 - 08/2000
2Artificial Membranes (Artificial Membrane)IBA
03/2001 - 06/2000
2batimastat (BB 94)IBA
11/2000 - 07/2000
2Creatine Kinase (Creatine Phosphokinase)IBA
08/2000 - 06/2000
2EnzymesIBA
07/2000 - 01/2000
1Cytotoxins (Cytolysins)IBA
01/2021
1Anticonvulsants (Antiepileptic Drugs)IBA
10/2020
1Antidepressive Agents (Antidepressants)IBA
10/2020
1Analgesics (Analgesic Drugs)IBA
10/2020
1Immunoglobulin FragmentsIBA
09/2014
1Furosemide (Lasix)FDA LinkGeneric
07/2014
1Linezolid (Zyvox)FDA Link
03/2011
1Adrenal Cortex Hormones (Corticosteroids)IBA
03/2011
1CoagulaseIBA
03/2011
1pimagedine (aminoguanidine)IBA
06/2006
1NG-Nitroarginine Methyl Ester (L-NAME)IBA
06/2006
1Nitric Oxide Synthase (NO Synthase)IBA
06/2006
1Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2006
1Methysergide (Sansert)FDA Link
05/2003
1GuanethidineFDA Link
05/2003
1Indomethacin (Indometacin)FDA LinkGeneric
05/2003
14-bromophenacyl bromideIBA
05/2003
1Interleukin-1 (Interleukin 1)IBA
05/2003
1Peptides (Polypeptides)IBA
05/2003
1Phospholipases AIBA
05/2003
1Prazosin (Minipress)FDA LinkGeneric
05/2003
1Promethazine (Promet)FDA LinkGeneric
05/2003
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
05/2003
1Serotonin AntagonistsIBA
05/2003
1Atenolol (Tenormin)FDA LinkGeneric
05/2003
1Sympathomimetics (Sympathomimetic Amines)IBA
05/2003
1Yohimbine (Yocon)IBA
05/2003
1Histamine (Histamine Dihydrochloride)FDA Link
05/2003
1Bothrops jararaca VenomIBA
10/2002
1CytokinesIBA
12/2001
1Edetic Acid (EDTA)FDA Link
09/2001
1CrotoxinIBA
09/2001
1Dexamethasone (Maxidex)FDA LinkGeneric
08/2001
1LeukotrienesIBA
08/2001
1Protein Isoforms (Isoforms)IBA
07/2001
1pyridyldithioethylamineIBA
07/2001
1neuwiedaseIBA
06/2001
1aspercetinIBA
04/2001
1Neuromuscular Agents (Skeletal Muscle Relaxants)IBA
03/2001
1Fish VenomsIBA
02/2001
1Chelating AgentsIBA
11/2000
1PeptidomimeticsIBA
11/2000
1Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
08/2000
1Virulence Factors (Pathogenicity Factors)IBA
08/2000
1Type C PhospholipasesIBA
08/2000

Therapy/Procedure

1Electrodes (Electrode)
07/2014
1Punctures
07/2014
1General Anesthesia
07/2014
1Craniotomy
03/2011
1Therapeutics
03/2011
1Analgesia
08/2007
1Intramuscular Injections
06/2006
1Injections
05/2003
1Aftercare (After-Treatment)
09/2001
1Subcutaneous Injections
06/2001