Roger N Gunn Selected Research

GSK215083

12/2015

Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Roger N Gunn Research Topics

Disease

11	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 09/2010
9	Neuroinflammatory Diseases 01/2023 - 01/2011
8	Parkinson Disease (Parkinson's Disease) 01/2020 - 10/2015
7	Schizophrenia (Dementia Praecox) 06/2023 - 06/2009
7	Disease Progression 12/2020 - 01/2017
5	Cognitive Dysfunction 01/2022 - 09/2010
4	Inflammation (Inflammations) 01/2023 - 12/2016
3	Huntington Disease (Huntington's Disease) 01/2023 - 10/2015
3	Dementia (Dementias) 01/2021 - 08/2017
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 09/2016
3	Multiple Sclerosis 11/2017 - 07/2014
3	Neoplasms (Cancer) 06/2005 - 10/2002
2	Gliosis 01/2023 - 10/2019
2	Atrophy 01/2022 - 11/2017
2	Lung Diseases (Lung Disease) 12/2020 - 01/2017
2	Alcoholism (Alcohol Abuse) 01/2020 - 06/2014
2	Gambling (Pathological Gambling) 01/2020 - 11/2017
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2019 - 01/2018
2	Major Depressive Disorder (Major Depressive Disorders) 01/2019 - 08/2013
2	Opioid-Related Disorders (Opiate Addiction) 11/2017 - 01/2016
1	Sarcoma (Soft Tissue Sarcoma) 01/2022
1	Disorders of Excessive Somnolence (Hypersomnia) 01/2020
1	Cardiotoxicity 12/2019
1	Parkinsonian Disorders (Parkinsonism) 01/2019
1	Movement Disorders (Movement Disorder) 01/2019
1	Rheumatoid Arthritis 01/2018
1	Brain Injuries (Brain Injury) 01/2018
1	Chronic Obstructive Pulmonary Disease (COPD) 12/2017
1	Pneumonia (Pneumonitis) 12/2017
1	Neurobehavioral Manifestations 08/2017
1	Encephalitis (Encephalitis, Rasmussen) 12/2016
1	Spinal Cord Diseases 12/2016
1	Crohn Disease (Crohn's Disease) 11/2016
1	Substance-Related Disorders (Drug Abuse) 01/2016
1	Dyskinesias (Dyskinesia) 10/2015

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2014
8	Biomarkers (Surrogate Marker)IBA 10/2020 - 10/2002
7	Amyloid (Amyloid Fibrils)IBA 01/2022 - 09/2010
5	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 10/2019 - 10/2015
3	Glycoproteins (Glycoprotein)IBA 06/2023 - 01/2020
3	(methyl- (11)C)N- acetyl- N- (2- methoxybenzyl)- 2- phenoxy- 5- pyridinamineIBA 01/2023 - 12/2016
3	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 12/2020 - 01/2017
3	LigandsIBA 01/2020 - 11/2017
3	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 03/2002
3	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 10/2019 - 01/2019
3	ThymidineIBA 06/2005 - 10/2002
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 09/2010
2	Dextroamphetamine (Dexedrine)FDA LinkGeneric 01/2020 - 01/2020
2	Antipsychotic Agents (Antipsychotics)IBA 01/2020 - 09/2002
2	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2020 - 01/2016
2	RolipramIBA 01/2020 - 08/2017
2	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 01/2020 - 08/2017
2	SynucleinsIBA 10/2019 - 01/2019
2	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 05/2014
2	Levodopa (L Dopa)FDA LinkGeneric 08/2017 - 10/2015
1	Indicators and Reagents (Reagents)IBA 01/2023
1	laquinimodIBA 01/2023
1	tau Proteins (tau Protein)IBA 01/2023
1	Pyruvic Acid (Pyruvate)IBA 01/2022
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2022
1	Amyloid beta-PeptidesIBA 01/2022
1	Urea (Carbamide)FDA LinkGeneric 01/2022
1	Glutamic Acid (Glutamate)FDA Link 01/2021
1	N-acetylaspartate (N-acetyl aspartate)IBA 01/2021
1	Opioid Analgesics (Opioids)IBA 01/2020
1	BromidesIBA 12/2019
1	triphenylphosphoniumIBA 12/2019
1	ethyleneIBA 12/2019
1	TriazolesIBA 12/2019
1	CationsIBA 12/2019
1	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2019
1	ImidazolinesIBA 10/2019
1	3- amino- 4- (2- dimethylaminomethylphenylsulfanyl)benzonitrileIBA 01/2019
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2019
1	Complement System Proteins (Complement)IBA 01/2019
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2019
1	neuromelaninIBA 01/2019
1	2- carbomethoxy- 8- (3- fluoropropyl)- 3- (4- iodophenyl)tropaneIBA 01/2019
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2019
1	Protein AggregatesIBA 03/2018
1	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 03/2018
1	Minocycline (Cyclops)FDA LinkGeneric 01/2018
1	Fibrinogen (Factor I)FDA Link 12/2017
1	GABA-A Receptors (GABA(A) Receptor)IBA 11/2017
1	FluorineIBA 11/2016
1	Huntingtin ProteinIBA 09/2016
1	Opioid Receptors (Opioid Receptor)IBA 01/2016
1	IMA107IBA 01/2016
1	Cocaine (Cocaine HCl)IBA 01/2016
1	3- benzenesulfonyl- 8- piperazin- 1- ylquinolineIBA 12/2015
1	GSK215083IBA 12/2015
1	EnzymesIBA 10/2015
1	Dopamine D3 ReceptorsIBA 06/2014
1	HeptanesIBA 08/2013
1	1- (3,4- dichlorophenyl)- 6- (methoxymethyl)- 4- azabicyclo(4.1.0)heptaneIBA 08/2013
1	Glycine Plasma Membrane Transport ProteinsIBA 12/2011
1	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 09/2010

Therapy/Procedure

2	Drug Therapy (Chemotherapy) 12/2019 - 10/2015
2	Therapeutics 01/2018 - 10/2015
1	Intravenous Administration 01/2022