Michelle L Gumz Selected Research

Mineralocorticoids

9/2020	Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
1/2019	Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure.
1/2019	Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.
1/2018	Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.
1/2011	Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases.

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Michelle L Gumz Research Topics

Disease

12	Hypertension (High Blood Pressure) 11/2023 - 04/2011
2	Kidney Diseases (Kidney Disease) 11/2023 - 01/2022
2	Chronic Renal Insufficiency 03/2023 - 01/2023
2	Neoplasms (Cancer) 08/2007 - 12/2006
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2023
1	Diabetic Nephropathies (Diabetic Nephropathy) 09/2022
1	Pulmonary Hypertension 01/2022
1	Vascular Diseases (Vascular Disease) 01/2022
1	Muscle Weakness 01/2022
1	Vascular Remodeling 01/2022
1	Stroke (Strokes) 01/2021
1	Hypoxia (Hypoxemia) 01/2020
1	Hypersensitivity (Allergy) 08/2016
1	Body Weight (Weight, Body) 12/2015
1	Weight Gain 01/2011
1	Lung Neoplasms (Lung Cancer) 02/2009
1	Renal Cell Carcinoma (Grawitz Tumor) 08/2007
1	Neoplasm Metastasis (Metastasis) 12/2006

Drug/Important Bio-Agent (IBA)

10	SaltsIBA 11/2023 - 12/2015
5	Proteins (Proteins, Gene)FDA Link 11/2022 - 01/2019
5	MineralocorticoidsIBA 09/2020 - 01/2011
3	Transcription Factors (Transcription Factor)IBA 01/2022 - 09/2020
2	AldosteroneIBA 11/2023 - 01/2022
2	deoxycortone pivalate FDA Link 01/2022 - 01/2011
2	SodiumIBA 09/2020 - 04/2011
1	Endothelins (Endothelin)IBA 03/2023
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2023
1	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2023
1	Endothelin Receptor AntagonistsIBA 09/2022
1	Endothelin Receptors (Endothelin Receptor)IBA 09/2022
1	ElementsIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	Cadherins (E-Cadherin)IBA 01/2022
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2020
1	CLOCK ProteinsIBA 01/2020
1	Desoxycorticosterone (Deoxycorticosterone)IBA 01/2019
1	ChromatinIBA 08/2016
1	PPAR gammaIBA 02/2009
1	efatutazoneIBA 02/2009
1	Histone Deacetylase InhibitorsIBA 02/2009
1	WD repeat containing planar cell polarity effectorIBA 08/2007
1	Keratin-7 (Cytokeratin 7)IBA 12/2006
1	sodium-iodide symporter (sodium iodide symporter)IBA 12/2006
1	Thyroglobulin FDA Link 12/2006
1	Thyrotropin Receptors (Thyrotropin Receptor)IBA 12/2006
1	ErbB Receptors (EGF Receptor)IBA 12/2006
1	Epidermal Growth Factor (EGF)IBA 12/2006

Therapy/Procedure

3	Chronotherapy 01/2023 - 04/2011
3	Therapeutics 01/2022 - 01/2018
1	Precision Medicine 01/2023