Demet Sinem Guden Selected Research

Shock

12/2019	Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock.
1/2019	NF-κB activation mediates LPS-or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock.

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Demet Sinem Guden Research Topics

Disease

9	Inflammation (Inflammations) 03/2022 - 05/2016
5	Septic Shock (Toxic Shock Syndrome) 01/2022 - 05/2016
5	Hypotension (Low Blood Pressure) 01/2022 - 05/2016
3	Hyperalgesia 03/2021 - 04/2017
2	Neuroinflammatory Diseases 03/2022 - 09/2021
2	Tachycardia (Tachyarrhythmias) 01/2022 - 05/2016
2	Pain (Aches) 03/2021 - 01/2021
2	Shock 12/2019 - 01/2019
1	Mental Disorders (Mental Disorder) 03/2022
1	Arteritis 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Hypoxia (Hypoxemia) 09/2021
1	B-Cell Lymphoma (Lymphoma, B Cell) 09/2021
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2020
1	Multiple Sclerosis 12/2020
1	Wounds and Injuries (Trauma) 12/2019
1	Ischemia 12/2019
1	Necrosis 01/2019
1	Neoplasms (Cancer) 05/2017
1	Sepsis (Septicemia) 05/2017
1	Metabolic Diseases (Metabolic Disease) 05/2017
1	Endotoxemia 05/2016

Drug/Important Bio-Agent (IBA)

7	LipopolysaccharidesIBA 01/2022 - 04/2017
3	TOR Serine-Threonine KinasesIBA 09/2021 - 05/2017
3	InflammasomesIBA 01/2021 - 04/2017
3	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 12/2019 - 05/2017
3	Vasodilator Agents (Vasodilators)IBA 01/2019 - 05/2017
2	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 01/2022 - 05/2016
2	N-(20-hydroxyeicosa-5,14-dienoyl)glycineIBA 01/2022 - 05/2016
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2022 - 05/2016
2	Sirolimus (Rapamycin)FDA Link 09/2021 - 12/2019
2	CytokinesIBA 03/2021 - 12/2019
2	NucleotidesIBA 01/2021 - 04/2017
2	Caspase 1 (ICE Protease)IBA 01/2021 - 04/2017
2	Epoxide HydrolasesIBA 01/2021 - 12/2020
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2017
2	Protein Isoforms (Isoforms)IBA 12/2019 - 04/2017
2	Nitric Oxide Synthase (NO Synthase)IBA 12/2019 - 01/2019
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2019 - 05/2017
2	ZymosanIBA 01/2019 - 02/2018
2	NADP (NADPH)IBA 02/2018 - 04/2017
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 05/2017 - 04/2017
1	Biomarkers (Surrogate Marker)IBA 03/2022
1	C-Reactive ProteinIBA 03/2022
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2022
1	bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA 09/2021
1	Caspase 3 (Caspase-3)IBA 09/2021
1	Neuroprotective AgentsIBA 03/2021
1	Bexarotene (LGD1069)FDA Link 03/2021
1	InterleukinsIBA 01/2021
1	14,15-dihydroxyeicosatrienoic acidIBA 01/2021
1	BradykininIBA 12/2019
1	Serotonin (5 Hydroxytryptamine)IBA 12/2019
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2019
1	NitrogenIBA 12/2019
1	Histamine (Histamine Dihydrochloride)FDA Link 12/2019
1	EndotoxinsIBA 12/2019
1	Vasoconstrictor AgentsIBA 12/2019
1	EicosanoidsIBA 12/2019
1	Oxygen (Dioxygen)IBA 12/2019
1	Arachidonic Acid (Vitamin F)IBA 12/2019
1	Interleukin-8 (Interleukin 8)IBA 01/2019
1	Syk KinaseIBA 01/2019
1	2- (7- (3,4- dimethoxyphenyl)imidazo(1,2- c)pyrimidin- 5- ylamino)nicotinamideIBA 01/2019
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 02/2018
1	NADPH Oxidases (NAD(P)H oxidase)IBA 02/2018
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 02/2018
1	Phosphotransferases (Kinase)IBA 02/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2017
1	Peroxidase (Myeloperoxidase)IBA 05/2017
1	Epoprostenol (Prostacyclin)FDA LinkGeneric 05/2017
1	Peroxynitrous Acid (Peroxynitrite)IBA 05/2017
1	Ribosomal Protein S6IBA 05/2017
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 05/2017
1	Toll-Like Receptor 4IBA 05/2017
1	EnzymesIBA 05/2017
1	3-nitrotyrosineIBA 04/2017
1	Oxidoreductases (Dehydrogenase)IBA 04/2017
1	N- (1,2,3,5,6,7- hexahydro- S- indacen- 4- ylcarbamoyl)- 4- (2- hydroxy- 2- propanyl)- 2- furansulfonamideIBA 04/2017
1	CaspasesIBA 04/2017
1	Leucine-Rich Repeat ProteinsIBA 04/2017
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 05/2016

Therapy/Procedure

3	Controlled Hypotension 01/2022 - 05/2017