Raphaela Goldbach-Mansky Selected Research

Interleukin-1 Receptors (Interleukin 1 Receptor)

7/2023	Anakinra-Associated Systemic Amyloidosis.
1/2022	The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist.
1/2022	The 2021 EULAR/American College of Rheumatology Points to Consider for Diagnosis, Management and Monitoring of the Interleukin-1 Mediated Autoinflammatory Diseases: Cryopyrin-Associated Periodic Syndromes, Tumour Necrosis Factor Receptor-Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Interleukin-1 Receptor Antagonist.
1/2021	Novel Majeed Syndrome-Causing LPIN2 Mutations Link Bone Inflammation to Inflammatory M2 Macrophages and Accelerated Osteoclastogenesis.
8/2017	Rilonacept maintains long-term inflammatory remission in patients with deficiency of the IL-1 receptor antagonist.
12/2015	Identification of Interleukin-1β-Producing Monocytes That Are Susceptible to Pyronecrotic Cell Death in Patients With Neonatal-Onset Multisystem Inflammatory Disease.
1/2014	IL-1 blockade in autoinflammatory syndromes.
11/2013	Deficiency of interleukin-1 receptor antagonist responsive to anakinra.
1/2012	Homeostatic tissue responses in skin biopsies from NOMID patients with constitutive overproduction of IL-1β.
5/2010	Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: finding the right balance in response to danger signals.

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Raphaela Goldbach-Mansky Research Topics

Disease

36	Cryopyrin-Associated Periodic Syndromes 07/2023 - 12/2002
27	Inflammation (Inflammations) 04/2024 - 08/2006
12	Bites and Stings (Sting) 01/2022 - 09/2015
11	Fever (Fevers) 05/2021 - 08/2007
9	Rheumatoid Arthritis 04/2024 - 01/2003
7	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2022 - 12/2011
7	Infections 11/2022 - 08/2007
7	Macrophage Activation Syndrome 07/2020 - 10/2014
6	Mevalonate Kinase Deficiency 01/2022 - 06/2013
6	Exanthema (Rash) 07/2017 - 08/2006
5	Skin Diseases (Skin Disease) 01/2023 - 11/2013
5	Osteomyelitis 01/2021 - 12/2011
5	Gout 01/2014 - 01/2008
4	chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature 04/2024 - 03/2012
4	Lipodystrophy 01/2023 - 11/2015
4	COVID-19 11/2022 - 10/2020
4	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 01/2022 - 12/2008
4	Lung Diseases (Lung Disease) 01/2022 - 09/2010
4	Familial Mediterranean Fever (Periodic Disease) 01/2021 - 06/2013
4	Dermatomyositis (Dermatopolymyositis) 01/2020 - 11/2019
3	Amyloidosis 02/2024 - 12/2022
3	Autoimmune Diseases (Autoimmune Disease) 10/2022 - 01/2018
3	Necrosis 01/2022 - 01/2021
3	Majeed syndrome 01/2021 - 12/2011
3	autosomal dominant familial Periodic fever 01/2021 - 07/2008
3	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2020 - 07/2015
3	Aseptic Meningitis 06/2017 - 08/2007
3	Arthritis (Polyarthritis) 01/2014 - 01/2003
2	Ulcer 01/2023 - 01/2017
2	Neutropenia 01/2022 - 01/2021
2	Pyogenic arthritis, pyoderma gangrenosum, and acne 01/2021 - 06/2013
2	Pharyngitis (Sore Throat) 01/2021 - 04/2011
2	Lymphadenitis (Adenitis) 01/2021 - 04/2011
2	Pneumonia (Pneumonitis) 01/2021 - 10/2020
2	Aphthous Stomatitis (Aphthous Ulcer) 01/2021 - 04/2011
2	Myositis (Idiopathic Inflammatory Myopathies) 01/2020 - 07/2015
2	Enterocolitis 01/2018 - 09/2010
2	Chronic Disease (Chronic Diseases) 01/2018 - 11/2015
2	Hearing Loss (Hearing Impairment) 12/2017 - 08/2011
2	Body Weight (Weight, Body) 12/2017 - 08/2006
2	Anaphylaxis (Anaphylactic Shock) 07/2017 - 05/2009
2	Urticaria (Hives) 06/2017 - 05/2009
2	Coronary Artery Disease (Coronary Atherosclerosis) 01/2014 - 09/2010
2	Neoplasms (Cancer) 01/2011 - 09/2009
2	Joint Diseases (Joint Disease) 08/2007 - 01/2003
2	Spondylarthropathies 04/2003 - 01/2003
1	Nephrotic Syndrome (Syndrome, Nephrotic) 07/2023
1	Amyloid Plaque 07/2023
1	Fibrosis (Cirrhosis) 01/2023
1	Abdominal Pain (Pain, Abdominal) 01/2023
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2023

Drug/Important Bio-Agent (IBA)

26	Interleukin-1 (Interleukin 1)IBA 01/2022 - 12/2002
19	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 02/2024 - 08/2006
12	Proteins (Proteins, Gene)FDA Link 07/2023 - 07/2006
12	InflammasomesIBA 01/2022 - 12/2009
11	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 07/2023 - 12/2002
10	Proteasome Endopeptidase Complex (Proteasome)IBA 04/2024 - 03/2012
10	InterferonsIBA 11/2022 - 01/2018
9	AutoantibodiesIBA 10/2020 - 01/2003
8	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2008
7	CytokinesIBA 11/2022 - 12/2002
7	Interleukin-18 (Interleukin 18)IBA 01/2020 - 07/2015
6	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 12/2002
5	baricitinibIBA 04/2024 - 04/2015
5	Acute-Phase Proteins (Acute-Phase Protein)IBA 01/2021 - 07/2008
5	InterleukinsIBA 11/2013 - 07/2008
4	Interferon Type IIBA 01/2022 - 07/2015
3	Deficiency of interleukin-1 receptor antagonistIBA 01/2021 - 06/2012
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 07/2008
3	PyrinIBA 01/2020 - 12/2002
3	C-Reactive ProteinIBA 06/2017 - 08/2008
3	canakinumab FDA Link 01/2017 - 12/2011
3	AntibodiesIBA 09/2009 - 01/2003
2	Janus Kinase InhibitorsIBA 04/2024 - 01/2016
2	src-Family KinasesIBA 01/2023 - 01/2021
2	Phosphotransferases (Kinase)IBA 01/2023 - 10/2022
2	Antiviral Agents (Antivirals)IBA 11/2022 - 01/2018
2	UbiquitinIBA 01/2022 - 01/2021
2	EnzymesIBA 05/2021 - 04/2003
2	LigandsIBA 01/2021 - 02/2017
2	Immunoglobulin E (IgE)IBA 01/2021 - 05/2009
2	Immunoglobulin G (IgG)IBA 10/2020 - 01/2003
2	Interleukin-6 (Interleukin 6)IBA 07/2020 - 01/2017
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020 - 12/2011
2	Adenosine DeaminaseIBA 01/2020 - 03/2014
2	Etanercept (Enbrel)FDA Link 12/2017 - 05/2009
2	Serum Amyloid A Protein (Serum Amyloid A)IBA 06/2017 - 08/2008
2	Uric Acid (Urate)IBA 01/2014 - 01/2008
2	NF-kappa B (NF-kB)IBA 05/2012 - 05/2012
2	rilonacept FDA Link 12/2011 - 08/2008
2	Sulfasalazine (Azulfidine)FDA LinkGeneric 08/2009 - 05/2009
2	Interleukin-1beta (Interleukin 1 beta)IBA 08/2008 - 08/2006
1	Congo RedIBA 07/2023
1	Dasatinib (BMS 354825)FDA Link 01/2023

Therapy/Procedure

11	Therapeutics 11/2022 - 07/2008
3	Injections 07/2023 - 08/2006
2	Aftercare (After-Treatment) 01/2017 - 01/2012
2	Biological Therapy 01/2016 - 05/2009
1	Drug Tapering 04/2024
1	Subcutaneous Injections 07/2023