C A Frye Selected Research

Progesterone

9/2014	Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats.
9/2007	In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C.
12/2006	In the ventral tegmental area, cyclic AMP mediates the actions of progesterone at dopamine type 1 receptors for lordosis of rats and hamsters.
5/2006	Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3alpha,5alpha-THP-facilitated lordosis.
4/2006	Rats bred for high versus low anxiety responses neonatally demonstrate increases in lordosis, pacing behavior, and midbrain 3 alpha, 5 alpha-THP levels as adults.
9/2005	Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus.
11/2001	The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents.
10/2001	Progesterone and 3alpha,5alpha-THP enhance sexual receptivity in mice.
9/2001	The role of neurosteroids and nongenomic effects of progestins in the ventral tegmental area in mediating sexual receptivity of rodents.
10/2000	Anti-sense oligonucleotides, for progestin receptors in the VMH and glutamic acid decarboxylase in the VTA, attenuate progesterone-induced lordosis in hamsters and rats.

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C A Frye Research Topics

Disease

16	Lordosis 09/2014 - 10/2000
4	Seizures (Absence Seizure) 08/2001 - 01/2000
3	Shock 09/2001 - 07/2000
2	Epilepsy (Aura) 10/2005 - 05/2000
1	Gambling (Pathological Gambling) 02/2010
1	Dementia (Dementias) 12/2009
1	Partial Epilepsies (Epilepsy, Partial) 10/2005

Drug/Important Bio-Agent (IBA)

11	Progesterone FDA LinkGeneric 09/2014 - 05/2000
7	Progestins (Progestagens)IBA 11/2013 - 09/2001
6	Hormones (Hormone)IBA 11/2013 - 12/2001
5	GABA-A Receptors (GABA(A) Receptor)IBA 09/2007 - 09/2001
5	gamma-Aminobutyric Acid (GABA)IBA 09/2007 - 09/2001
5	Finasteride (Propecia)FDA LinkGeneric 09/2005 - 06/2001
4	Progesterone Receptors (Progesterone Receptor)IBA 12/2006 - 10/2000
3	Estradiol (Delestrogen)FDA LinkGeneric 09/2014 - 12/2006
2	Dopamine (Intropin)FDA LinkGeneric 09/2007 - 12/2006
2	MuscimolIBA 09/2007 - 10/2001
2	Testosterone (Sustanon)FDA Link 10/2005 - 11/2001
2	N,N- di- n- hexyl- 2- (4- fluorophenyl)indole- 3- acetamideIBA 07/2003 - 07/2000
2	epostaneIBA 12/2001 - 10/2001
2	glutathione-bicarbonate-Ringer solution (BSS plus)FDA LinkGeneric 11/2001 - 09/2001
2	NeurosteroidsIBA 11/2001 - 09/2001
2	Pentylenetetrazole (Metrazol)IBA 08/2001 - 10/2000
1	EnzymesIBA 09/2014
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 09/2014
1	XenobioticsIBA 09/2014
1	Hydrocortisone (Cortisol)FDA LinkGeneric 02/2010
1	Phosphotransferases (Kinase)IBA 09/2007
1	GTP-Binding Proteins (G-Protein)IBA 09/2007
1	2,3,4,5- Tetrahydro- 7,8- dihydroxy- 1- phenyl- 1H- 3- benzazepine (SKF 38393)IBA 09/2007
1	1- (6- ((3- methoxyestra- 1,3,5(10)- trien- 17- yl)amino)hexyl)- 1H- pyrrole- 2,5- dioneIBA 09/2007
1	bisindolylmaleimideIBA 09/2007
1	Protein Kinases (Protein Kinase)IBA 09/2007
1	Protein Kinase CIBA 09/2007
1	Type C PhospholipasesIBA 09/2007
1	2',5'-dideoxyadenosineIBA 12/2006
1	Adenylyl Cyclases (Adenylyl Cyclase)IBA 12/2006
1	Cyclic AMP (AMP, Cyclic)IBA 12/2006
1	8-Bromo Cyclic Adenosine Monophosphate (8 Bromo Cyclic Adenosine Monophosphate)IBA 12/2006
1	Pregnanolone (Allopregnanolone)IBA 04/2006
1	Glutamate Receptors (Glutamate Receptor)IBA 01/2006
1	N-Methylaspartate (NMDA)IBA 01/2006
1	Dopamine Receptors (Dopamine Receptor)IBA 01/2006
1	Lamotrigine (Lamictal)FDA LinkGeneric 10/2005
1	Phenytoin (Dilantin)FDA LinkGeneric 10/2005
1	Carbamazepine (Tegretol)FDA LinkGeneric 10/2005
1	Anticonvulsants (Antiepileptic Drugs)IBA 10/2005
1	Digitoxin FDA Link 09/2005
1	Indomethacin (Indometacin)FDA LinkGeneric 12/2001
1	Steroid Receptors (Steroid Receptor)IBA 11/2001
1	Androgen Receptors (Androgen Receptor)IBA 11/2001
1	androstaneIBA 11/2001
1	Mifepristone (RU 486)FDA Link 10/2001
1	AndrogensIBA 06/2001
1	PicrotoxinIBA 06/2001
1	betadex (beta-cyclodextrin)IBA 10/2000
1	Antisense OligonucleotidesIBA 10/2000
1	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 10/2000
1	Anti-Anxiety Agents (Anxiolytics)IBA 07/2000
1	Kainic Acid (Kainate)IBA 05/2000
1	Dizocilpine Maleate (Dizocilpine)IBA 01/2000
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2000

Therapy/Procedure

2	Injections 06/2001 - 07/2000
1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 12/2009
1	Cannula 07/2003