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Edmund Ellsworth Selected Research

Neoplasms (Cancer)

2/2023The Novel RXR Agonist MSU-42011 Differentially Regulates Gene Expression in Mammary Tumors of MMTV-Neu Mice.
4/2022Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma.
10/2021The RXR Agonist MSU42011 Is Effective for the Treatment of Preclinical HER2+ Breast Cancer and Kras-Driven Lung Cancer.
12/2020The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer.
1/2020Therapeutic potential of targeting mixed lineage kinases in cancer and inflammation.

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Edmund Ellsworth Research Topics

Disease

5Neoplasms (Cancer)
02/2023 - 01/2020
3Tuberculosis (Tuberculoses)
12/2023 - 10/2019
2Infections
12/2023 - 04/2007
2Inflammation (Inflammations)
12/2020 - 01/2020
1Alzheimer Disease (Alzheimer's Disease)
11/2022
1Neuroblastoma
11/2022
1Cognitive Dysfunction
11/2022
1Multiple Myeloma
04/2022
1Substance-Related Disorders (Drug Abuse)
04/2022
1Cocaine-Related Disorders (Cocaine Addiction)
04/2022
1Breast Neoplasms (Breast Cancer)
10/2021
1Lung Neoplasms (Lung Cancer)
10/2021
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
10/2021
1Carcinogenesis
10/2021
1Hypertriglyceridemia
12/2020
1Hypoxia (Hypoxemia)
01/2020
1Pneumococcal Pneumonia
04/2007

Drug/Important Bio-Agent (IBA)

3Proteins (Proteins, Gene)FDA Link
12/2023 - 04/2022
3Bexarotene (LGD1069)FDA Link
02/2023 - 12/2020
2Retinoid X Receptors (Retinoid X Receptor)IBA
02/2023 - 12/2020
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
02/2023
1RNA (Ribonucleic Acid)IBA
02/2023
1SulfonamidesIBA
11/2022
1Proteasome Endopeptidase Complex (Proteasome)IBA
04/2022
1ATP dependent 26S protease (26S proteasome)IBA
04/2022
1UbiquitinIBA
04/2022
1Transcription Factors (Transcription Factor)IBA
04/2022
1Cocaine (Cocaine HCl)IBA
04/2022
1vinyl carbamateIBA
10/2021
1AntibodiesIBA
10/2021
1Triglycerides (Triacylglycerol)IBA
01/2020
1Phosphotransferases (Kinase)IBA
01/2020
1Growth InhibitorsIBA
10/2019
1TrehaloseIBA
10/2019
13- amino- 7- (3- (1- aminoethyl)pyrrolidin- 1- yl)- 1- cyclopropyl- 6- fluoro- 8- methyl- 1H- quinazoline- 2,4- dioneIBA
04/2007
1Levofloxacin (Levaquin)FDA Link
04/2007

Therapy/Procedure

3Therapeutics
11/2022 - 01/2020
1Immunotherapy
10/2021