Joan Ellis Selected Research

Amyloid (Amyloid Fibrils)

1/2009	First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
3/2008	In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

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Joan Ellis Research Topics

Disease

3	Alzheimer Disease (Alzheimer's Disease) 01/2009 - 07/2007

Drug/Important Bio-Agent (IBA)

2	Proteins (Proteins, Gene)FDA Link 01/2009 - 03/2008
2	Amyloid (Amyloid Fibrils)IBA 01/2009 - 03/2008
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 03/2008 - 07/2007
1	Peptides (Polypeptides)IBA 01/2009
1	EnzymesIBA 01/2009
1	Amyloid beta-PeptidesIBA 03/2008