Gregory P Downey Selected Research

Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

4/2014	Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages.
2/2008	Role of PAR2 in murine pulmonary pseudomonal infection.

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Gregory P Downey Research Topics

Disease

21	Lung Diseases (Lung Disease) 01/2023 - 11/2002
12	Inflammation (Inflammations) 01/2023 - 01/2004
12	Lymphangioleiomyomatosis (Lymphangiomyomatosis) 01/2022 - 11/2002
11	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2022 - 04/2006
7	Infections 01/2021 - 03/2005
6	Neoplasms (Cancer) 01/2022 - 07/2012
5	Fibrosis (Cirrhosis) 01/2023 - 10/2011
5	Acute Lung Injury 01/2022 - 10/2012
4	COVID-19 09/2022 - 01/2021
4	Tuberous Sclerosis (Bourneville's Disease) 01/2019 - 10/2006
4	Lung Injury 03/2013 - 04/2003
3	Respiratory Hypersensitivity 01/2023 - 10/2020
3	Asthma (Bronchial Asthma) 10/2020 - 01/2004
3	Sepsis (Septicemia) 12/2006 - 05/2005
2	Arthritis (Polyarthritis) 01/2023 - 04/2006
2	Interstitial Lung Diseases (Interstitial Lung Disease) 06/2019 - 10/2006
2	Cysts 06/2019 - 08/2013
2	Pneumonia (Pneumonitis) 01/2018 - 02/2008
2	Pneumothorax 11/2017 - 02/2007
2	Idiopathic Pulmonary Fibrosis 04/2014 - 10/2011
2	Periodontitis 01/2013 - 04/2006
2	Necrosis 10/2009 - 10/2006
2	Bacterial Infections (Bacterial Infection) 07/2009 - 03/2005
1	Airway Obstruction (Choking) 01/2023
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2023
1	Autosomal Dominant Rhegmatogenous Retinal Detachment 10/2022
1	Breakthrough Infections 08/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2019
1	Disease Progression 01/2019
1	Vascular Diseases (Vascular Disease) 11/2018
1	Bronchitis 10/2016
1	Pulmonary Arterial Hypertension 01/2016
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2016
1	Neoplasm Metastasis (Metastasis) 08/2013
1	Lymphadenopathy 08/2013

Drug/Important Bio-Agent (IBA)

10	lipoarabinomannan (LAM)IBA 06/2019 - 11/2002
9	CytokinesIBA 01/2023 - 05/2005
8	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 04/2003
6	Matrix Metalloproteinases (MMPs)IBA 01/2022 - 10/2011
5	Proteins (Proteins, Gene)FDA Link 11/2018 - 04/2006
4	Particulate MatterIBA 01/2023 - 10/2020
4	Bleomycin (Blenoxane)FDA LinkGeneric 01/2020 - 10/2011
4	CollagenIBA 04/2014 - 04/2006
3	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2004
3	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2022 - 01/2016
3	AntibodiesIBA 08/2021 - 11/2009
3	Sirolimus (Rapamycin)FDA Link 01/2019 - 04/2011
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2014 - 10/2011
2	src-Family KinasesIBA 01/2023 - 12/2022
2	indium-bleomycinIBA 12/2022 - 04/2014
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2022 - 11/2018
2	Protein Tyrosine PhosphatasesIBA 01/2022 - 06/2019
2	Tyrosine (L-Tyrosine)FDA Link 01/2022 - 01/2017
2	Transcription Factors (Transcription Factor)IBA 01/2021 - 11/2018
2	EnzymesIBA 01/2021 - 01/2019
2	trans-sodium crocetinate (crocetin)IBA 01/2019 - 04/2007
2	NucleotidesIBA 10/2014 - 06/2014
2	Cell Surface ReceptorsIBA 08/2014 - 03/2009
2	Matrix Metalloproteinase 3 (Stromelysin 1)IBA 05/2014 - 10/2011
2	IntegrinsIBA 05/2014 - 04/2006
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2014 - 02/2008
2	LipopolysaccharidesIBA 01/2010 - 12/2006
2	Interleukin-1 (Interleukin 1)IBA 10/2006 - 05/2005
2	Pancreatic Elastase (Elastase)IBA 04/2003 - 12/2002
1	Adenosine Triphosphate (ATP)IBA 01/2023
1	Interleukin-13IBA 01/2023
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2023
1	nintedanibIBA 12/2022
1	pirfenidoneIBA 12/2022
1	saracatinibIBA 12/2022
1	mRNA VaccinesIBA 09/2022
1	BNT162 VaccineIBA 09/2022
1	AcidsIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2021
1	Interleukin-33IBA 10/2020
1	Metalloproteases (Metalloproteinases)IBA 01/2019
1	Bronchodilator Agents (Bronchodilators)IBA 01/2019
1	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 11/2018
1	Protein Kinases (Protein Kinase)IBA 11/2018
1	InflammasomesIBA 01/2018
1	PlasticsIBA 10/2016
1	Pattern Recognition ReceptorsIBA 10/2014
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2014
1	Toll-Like Receptors (Toll-Like Receptor)IBA 10/2014
1	Membrane Proteins (Integral Membrane Proteins)IBA 08/2014
1	Hydroxyproline (4 Hydroxyproline)IBA 04/2014
1	Vascular Endothelial Growth Factor DIBA 08/2013
1	CateninsIBA 03/2013
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2013
1	TalinIBA 11/2012
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2012
1	ErbB Receptors (EGF Receptor)IBA 10/2012

Therapy/Procedure

6	Therapeutics 01/2021 - 01/2004
2	Lung Transplantation 11/2017 - 07/2005
2	Artificial Respiration (Mechanical Ventilation) 01/2006 - 12/2002
1	Analgesia 01/2021
1	Pleurodesis 11/2017
1	Mechanical Ventilators (Ventilator) 01/2014
1	Ligation 01/2013