Jean Donadieu Selected Research

Vemurafenib

1/2021	Cutaneous adverse events in children treated with vemurafenib for refractory BRAFV600E mutated Langerhans cell histiocytosis.
11/2019	Vemurafenib for Refractory Multisystem Langerhans Cell Histiocytosis in Children: An International Observational Study.
9/2015	Vemurafenib Use in an Infant for High-Risk Langerhans Cell Histiocytosis.
7/2015	Vemurafenib as first line therapy in BRAF-mutated Langerhans cell histiocytosis.
2/2015	Reproducible and sustained efficacy of targeted therapy with vemurafenib in patients with BRAF(V600E)-mutated Erdheim-Chester disease.
10/2014	Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib.
2/2013	Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation.
9/2012	High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses.

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Jean Donadieu Research Topics

Disease

23	Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell) 01/2024 - 02/2004
16	Neutropenia 05/2024 - 01/2005
14	Autosomal Recessive 3 Severe Congenital Neutropenia 12/2022 - 06/2004
10	Infections 05/2024 - 01/2005
9	Neoplasms (Cancer) 12/2023 - 01/2005
8	Histiocytosis 01/2020 - 09/2012
5	Erdheim-Chester Disease 11/2019 - 02/2013
5	Leukemia 02/2013 - 04/2002
4	Glycogen Storage Disease (Glycogenosis) 01/2024 - 02/2002
4	Shwachman-Diamond Syndrome 10/2022 - 05/2011
3	Warts (Wart) 03/2024 - 09/2012
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2022 - 07/2006
3	Reinfection 10/2021 - 02/2002
3	Cyclic neutropenia 01/2021 - 06/2004
3	severe chronic Neutropenia 01/2021 - 04/2002
2	Virus Diseases (Viral Diseases) 05/2024 - 01/2020
2	Bacterial Infections (Bacterial Infection) 05/2024 - 09/2012
2	WHIM syndrome 04/2024 - 09/2012
2	Glycogen Storage Disease IB 01/2024 - 02/2002
2	Diabetes Insipidus 09/2019 - 07/2007
2	Nephrotic Syndrome (Syndrome, Nephrotic) 07/2018 - 05/2009
2	Exocrine Pancreatic Insufficiency 01/2018 - 05/2011
2	Thrombocytopenia (Thrombopenia) 12/2017 - 12/2009
2	Heart Failure 05/2013 - 05/2010
2	Granuloma 01/2012 - 08/2007
1	Communicable Diseases (Infectious Diseases) 05/2024
1	Candidiasis (Moniliasis) 05/2024
1	Dehydration (Water Stress) 01/2024
1	Aplastic Anemia (Anemia, Hypoplastic) 10/2022
1	Disease Progression 12/2020
1	Lung Diseases (Lung Disease) 01/2020
1	Pneumothorax 01/2020
1	Hyperglycemia 01/2019
1	Diabetes Mellitus 01/2019
1	Insulin Resistance 01/2019
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2019
1	Nephrosis 07/2018
1	Non-Langerhans-Cell Histiocytosis (Histiocytosis, Non Langerhans Cell) 01/2018
1	Hypoalphalipoproteinemias (Hypoalphalipoproteinemia) 01/2018

Drug/Important Bio-Agent (IBA)

10	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 10/2021 - 02/2002
8	VemurafenibIBA 01/2021 - 09/2012
6	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2021 - 06/2004
6	Cladribine FDA LinkGeneric 12/2020 - 12/2009
4	Vinblastine (Vinblastine Sulfate)FDA Link 01/2024 - 12/2011
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020 - 02/2016
4	Proteins (Proteins, Gene)FDA Link 06/2014 - 10/2007
3	Anti-Bacterial Agents (Antibiotics)IBA 04/2024 - 07/2006
3	Chemokine ReceptorsIBA 03/2024 - 09/2012
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 05/2024 - 04/2002
2	GlycogenIBA 01/2024 - 05/2011
2	Cytarabine (Cytosar-U)FDA LinkGeneric 11/2023 - 09/2015
2	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 12/2022 - 04/2012
2	DiamondIBA 10/2022 - 01/2018
2	AntibodiesIBA 01/2019 - 01/2019
2	Protein Isoforms (Isoforms)IBA 06/2014 - 01/2014
2	Interferon-alpha (Interferon Alfa)IBA 05/2012 - 02/2010
2	pegfilgrastim (Neulasta)FDA Link 12/2009 - 08/2009
1	Interferon-gamma (Interferon, gamma)IBA 05/2024
1	Interleukin-17 (Interleukin 17)IBA 05/2024
1	Interleukin-6 (Interleukin 6)IBA 05/2024
1	Complement System Proteins (Complement)IBA 05/2024
1	A-factor (Streptomyces)IBA 05/2024
1	Complement C3-C5 Convertases (C3 Convertase)IBA 05/2024
1	AutoantibodiesIBA 05/2024
1	CytokinesIBA 05/2024
1	Interferon Type IIBA 05/2024
1	mavorixaforIBA 04/2024
1	empagliflozinIBA 01/2024
1	Tyrosine Kinase InhibitorsIBA 12/2023
1	Sodium-Glucose Transport ProteinsIBA 12/2022
1	Phosphates (Orthophosphate)IBA 12/2022
1	EstersIBA 12/2022
1	Hypoglycemic Agents (Hypoglycemics)IBA 12/2022
1	1,5-anhydroglucitolIBA 12/2022
1	Endopeptidase ClpIBA 01/2022
1	NucleosidesIBA 12/2020
1	cobimetinibIBA 01/2020
1	trametinibIBA 01/2020
1	GonadotropinsIBA 09/2019
1	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 09/2019
1	Peptide Elongation Factors (Elongation Factor)IBA 01/2019
1	GTP Phosphohydrolases (GTPases)IBA 01/2019
1	Insulin ReceptorIBA 01/2019
1	Levamisole (Decaris)FDA Link 07/2018
1	SteroidsIBA 07/2018
1	LipidsIBA 01/2018
1	EnzymesIBA 01/2018
1	HDL CholesterolIBA 01/2018
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2018
1	Hemoglobins (Hemoglobin)IBA 12/2017
1	Mitogen-Activated Protein KinasesIBA 01/2017

Therapy/Procedure

22	Therapeutics 12/2023 - 02/2002
4	Drug Therapy (Chemotherapy) 10/2022 - 12/2014
3	Transplantation 10/2022 - 10/2015
3	Hematopoietic Stem Cell Transplantation 10/2015 - 05/2010
2	Lung Transplantation 01/2024 - 01/2020
2	Stem Cell Transplantation 10/2022 - 10/2015
1	Antibiotic Prophylaxis 10/2021
1	Off-Label Use 11/2019
1	Central Venous Catheters 10/2019