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Valérie Domenga-Denier Selected Research

Notch3 Receptor

2/2024Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL.
1/2018Notch3ECD immunotherapy improves cerebrovascular responses in CADASIL mice.
1/2017Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries.
2/2015Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.
4/2014Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model.
3/2014Archetypal Arg169Cys mutation in NOTCH3 does not drive the pathogenesis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy via a loss-of-function mechanism.
6/2013Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL.

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Valérie Domenga-Denier Research Topics

Disease

10CADASIL
02/2024 - 06/2013
1Cerebral Small Vessel Diseases
02/2024
1Hyperplasia
01/2020
1Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
01/2018
1Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
01/2017
1Stroke (Strokes)
01/2017
1Hyperemia
03/2016
1Channelopathies
02/2015
1Infarction (Infarctions)
03/2014

Drug/Important Bio-Agent (IBA)

7Notch3 ReceptorIBA
02/2024 - 06/2013
2Extracellular Matrix ProteinsIBA
03/2016 - 06/2013
2Heparin-binding EGF-like Growth Factor (HB-EGF)IBA
01/2016 - 02/2015
1Protein AggregatesIBA
02/2024
1Contractile ProteinsIBA
01/2020
1Fibrinogen (Factor I)FDA Link
11/2019
1Peptide Hydrolases (Proteases)FDA Link
01/2018
1Proteins (Proteins, Gene)FDA Link
01/2018
1ProteomeIBA
01/2018
1VitronectinIBA
03/2016
1Vasodilator Agents (Vasodilators)IBA
03/2016
1Potassium Channels (Potassium Channel)IBA
01/2016
1Tissue Inhibitor of Metalloproteinase-3IBA
01/2016
1PotassiumIBA
02/2015
1Detergents (Detergent)IBA
06/2013

Therapy/Procedure

1Immunotherapy
01/2018