Eleonora Distrutti Selected Research

Non-alcoholic Fatty Liver Disease

12/2023	Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G-Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease.
12/2023	Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
1/2023	Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH.
11/2022	Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling.
1/2022	Linking liver metabolic and vascular disease via bile acid signaling.
1/2022	Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling.
6/2020	Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH).
1/2018	Farnesoid X receptor modulators 2014-present: a patent review.

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Eleonora Distrutti Research Topics

Disease

35	Inflammation (Inflammations) 12/2023 - 01/2002
20	Colitis 01/2022 - 01/2002
10	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 11/2004
8	Fatty Liver 12/2023 - 01/2012
8	Non-alcoholic Fatty Liver Disease 12/2023 - 01/2018
8	Fibrosis (Cirrhosis) 01/2023 - 02/2004
7	Insulin Resistance 12/2023 - 07/2007
6	Neoplasms (Cancer) 03/2024 - 10/2007
5	Cholestasis 01/2020 - 07/2007
4	Adenocarcinoma 03/2024 - 01/2016
4	Dysbiosis 12/2023 - 10/2019
4	Stomach Neoplasms (Stomach Cancer) 11/2023 - 01/2016
4	Crohn Disease (Crohn's Disease) 01/2022 - 11/2009
4	Pruritus (Itching) 10/2021 - 12/2014
4	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019 - 12/2003
4	Obesity 01/2019 - 01/2013
4	Portal Hypertension 01/2016 - 12/2003
4	Pain (Aches) 01/2013 - 01/2006
3	Atherosclerosis 12/2023 - 10/2010
3	Body Weight (Weight, Body) 12/2023 - 01/2013
3	Hepatitis 01/2020 - 11/2009
3	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2020 - 12/2014
3	Disease Progression 01/2020 - 01/2018
3	Weight Loss (Weight Reduction) 01/2019 - 11/2004
2	Carcinogenesis 03/2024 - 01/2022
2	COVID-19 12/2023 - 01/2023
2	Chemical and Drug Induced Liver Injury 01/2023 - 01/2020
2	Vascular System Injuries 01/2022 - 10/2010
2	Liver Diseases (Liver Disease) 10/2021 - 01/2017
2	Acute Liver Failure (Fulminant Hepatic Failure) 01/2020 - 09/2004
2	Type 2 Diabetes Mellitus (MODY) 01/2015 - 07/2007
2	Rheumatoid Arthritis 12/2013 - 08/2011
2	Arthritis (Polyarthritis) 12/2013 - 08/2011
2	Dyslipidemias (Dyslipidemia) 01/2012 - 10/2010
2	Hyperalgesia 05/2009 - 07/2006

Drug/Important Bio-Agent (IBA)

28	Bile Acids and Salts (Bile Acids)IBA 03/2024 - 11/2009
18	LigandsIBA 12/2023 - 07/2007
10	Messenger RNA (mRNA)IBA 01/2022 - 01/2002
9	LipidsIBA 01/2023 - 01/2012
8	CytokinesIBA 03/2024 - 10/2011
7	CholesterolIBA 12/2023 - 02/2009
7	Interleukin-6 (Interleukin 6)IBA 01/2023 - 01/2011
6	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 01/2023 - 12/2003
6	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2013 - 11/2009
5	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 10/2006 - 09/2005
4	GTP-Binding Proteins (G-Protein)IBA 12/2023 - 01/2022
4	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2013
4	AcidsIBA 02/2019 - 10/2006
4	Sulfonic AcidsIBA 12/2017 - 01/2002
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2007 - 11/2002
3	Leukemia Inhibitory FactorIBA 03/2024 - 01/2023
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2023 - 01/2022
3	BAR502IBA 12/2023 - 01/2023
3	Apolipoproteins E (ApoE)IBA 12/2023 - 10/2010
3	ChemokinesIBA 01/2023 - 10/2011
3	obeticholic acidIBA 01/2020 - 12/2014
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 12/2014
3	Dextran SulfateIBA 12/2017 - 11/2009
3	sym-trinitrobenzeneIBA 12/2017 - 01/2002
3	CollagenIBA 12/2013 - 12/2002
3	SteroidsIBA 01/2013 - 11/2002
3	Rifaximin (L 105)FDA Link 10/2011 - 01/2002
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2009 - 01/2002
3	sodium bisulfide (NaHS)IBA 10/2006 - 09/2005
2	InterleukinsIBA 03/2024 - 01/2002
2	ApolipoproteinsIBA 12/2023 - 12/2023
2	Atorvastatin (Lipitor)FDA Link 12/2023 - 01/2022
2	FructoseIBA 12/2023 - 10/2019
2	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2023 - 01/2022
2	RNA (Ribonucleic Acid)IBA 11/2023 - 01/2022
2	OSM-LIF ReceptorsIBA 01/2023 - 01/2022
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2023 - 01/2019
2	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 01/2023 - 01/2020
2	oxidized low density lipoproteinIBA 10/2021 - 01/2019
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2021 - 08/2019
2	pelargonidinIBA 01/2021 - 08/2019
2	Interleukin-10 (Interleukin 10)IBA 06/2020 - 11/2002
2	isothiocyanic acidIBA 01/2020 - 01/2017
2	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2020 - 09/2004
2	Dextrans (Dextran)FDA Link 02/2019 - 01/2012
2	Insulin (Novolin)FDA Link 01/2019 - 01/2012
2	Alkaline PhosphataseIBA 01/2019 - 12/2014
2	Chenodeoxycholic Acid (Chenix)FDA Link 01/2019 - 10/2010
2	Drinking WaterIBA 12/2017 - 11/2009
2	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2017 - 11/2011
2	Proteins (Proteins, Gene)FDA Link 01/2016 - 01/2002
2	Ritonavir (Norvir)FDA Link 01/2014 - 10/2010
2	Integrin alpha1beta1IBA 01/2014 - 12/2002
2	Chemokine CCL5IBA 12/2013 - 10/2011
2	Pregnane X ReceptorIBA 12/2013 - 10/2011
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2013 - 04/2006
2	Analgesics (Analgesic Drugs)IBA 01/2013 - 06/2010
2	Adenosine Triphosphate (ATP)IBA 10/2006 - 10/2006
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2006 - 09/2005
2	Interleukin-2 (IL2)IBA 11/2004 - 01/2002
2	2- methyl- 3- (2- ((4- nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid esterIBA 09/2004 - 12/2003
2	Prednisolone (Predate)FDA LinkGeneric 11/2002 - 01/2002
1	Glycoproteins (Glycoprotein)IBA 03/2024

Therapy/Procedure

10	Therapeutics 03/2024 - 01/2013
2	Ligation 01/2020 - 02/2004