Pieter Depuydt Selected Research

Complement C5 (Complement 5)

8/2022

Efficacy and safety of the investigational complement C5 inhibitor zilucoplan in patients hospitalized with COVID-19: an open-label randomized controlled trial.

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Pieter Depuydt Research Topics

Disease

14	Critical Illness (Critically Ill) 11/2023 - 12/2005
9	Infections 09/2023 - 06/2005
8	COVID-19 11/2023 - 01/2020
5	Pneumonia (Pneumonitis) 10/2018 - 05/2006
4	Respiratory Insufficiency (Respiratory Failure) 12/2022 - 01/2021
4	Neoplasms (Cancer) 12/2018 - 02/2006
3	Hypoxia (Hypoxemia) 12/2022 - 07/2020
3	Invasive Pulmonary Aspergillosis 01/2021 - 02/2006
3	Cross Infection (Nosocomial Infection) 01/2021 - 06/2005
3	Sepsis (Septicemia) 10/2019 - 12/2005
2	Inflammation (Inflammations) 12/2022 - 08/2022
2	Lung Diseases (Lung Disease) 04/2022 - 01/2021
2	Poisoning 02/2022 - 01/2016
2	Invasive Fungal Infections 01/2021 - 10/2018
2	Human Influenza (Influenza) 01/2021 - 10/2018
2	Neutropenia 12/2018 - 02/2006
2	Mycoses (Diseases, Fungus) 10/2018 - 02/2006
2	Lactic Acidosis 01/2016 - 09/2010
2	Ventilator-Associated Pneumonia 05/2008 - 02/2007
2	Bacteremia 11/2006 - 06/2005
2	Healthcare-Associated Pneumonia 11/2006 - 05/2006
1	Hypoglycemia (Reactive Hypoglycemia) 09/2023
1	Acute Kidney Injury (Acute Renal Failure) 09/2023
1	Liver Diseases (Liver Disease) 09/2023
1	Chronic Obstructive Pulmonary Disease (COPD) 04/2023
1	Second Primary Neoplasms (Neoplasms, Second) 04/2023
1	Hyperkalemia 02/2022
1	Hypertriglyceridemia 01/2022
1	Cytokine Release Syndrome 12/2021
1	Lymphopenia (Lymphocytopenia) 12/2021
1	Hypoventilation 02/2021
1	Shock 10/2020
1	Hyperventilation 07/2020
1	Bacterial Infections (Bacterial Infection) 07/2020
1	Communicable Diseases (Infectious Diseases) 01/2020
1	Fistula 09/2019
1	Photophobia (Light Sensitivity) 03/2019
1	Intracranial Hypertension 03/2019
1	Headache (Headaches) 03/2019
1	Fever (Fevers) 03/2019
1	Dermatomyositis (Dermatopolymyositis) 12/2018
1	Antisynthetase syndrome 12/2018
1	Interstitial Lung Diseases (Interstitial Lung Disease) 12/2018
1	Polymyositis 12/2018
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2018

Drug/Important Bio-Agent (IBA)

17	Anti-Bacterial Agents (Antibiotics)IBA 04/2023 - 06/2005
3	Adrenal Cortex Hormones (Corticosteroids)IBA 04/2023 - 10/2018
3	Ferritins (Ferritin)IBA 01/2022 - 12/2018
2	beta-LactamsIBA 04/2023 - 05/2008
2	C-Reactive ProteinIBA 04/2023 - 12/2021
2	Interleukin-6 (Interleukin 6)IBA 01/2023 - 12/2021
2	Oxygen (Dioxygen)IBA 12/2021 - 07/2020
2	posaconazole FDA Link 01/2021 - 01/2021
2	Sodium Glutamate (Accent)IBA 10/2018 - 02/2006
2	Meropenem (Merrem)FDA LinkGeneric 05/2013 - 12/2010
1	Glucose (Dextrose)FDA LinkGeneric 09/2023
1	Insulin (Novolin)FDA Link 09/2023
1	Azithromycin (Zithromax)FDA LinkGeneric 04/2023
1	Theophylline (Theon)FDA LinkGeneric 04/2023
1	Complement System Proteins (Complement)IBA 01/2023
1	IronIBA 01/2023
1	Biomarkers (Surrogate Marker)IBA 01/2023
1	sargramostim (Leukine)FDA Link 12/2022
1	Antiviral Agents (Antivirals)IBA 12/2022
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 12/2022
1	zilucoplanIBA 08/2022
1	Complement C5 (Complement 5)IBA 08/2022
1	Carbon MonoxideIBA 04/2022
1	Digoxin (Digitek)FDA LinkGeneric 02/2022
1	Digitalis GlycosidesIBA 02/2022
1	Immunoglobulin Fab FragmentsIBA 02/2022
1	Interleukin-1 (Interleukin 1)IBA 12/2021
1	InterleukinsIBA 12/2021
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 12/2021
1	Analgesics (Analgesic Drugs)IBA 02/2021
1	Hydrocortisone (Cortisol)FDA LinkGeneric 10/2020
1	Oxyhemoglobins (Oxyhemoglobin)IBA 07/2020
1	Hemoglobins (Hemoglobin)IBA 07/2020
1	Methylene Blue (Methylthioninium Chloride)FDA Link 09/2019
1	Cytarabine (Cytosar-U)FDA LinkGeneric 03/2019
1	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 03/2019
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 12/2018
1	AutoantibodiesIBA 12/2018
1	AntibodiesIBA 12/2018
1	VaccinesIBA 01/2017
1	Recombinant ProteinsIBA 01/2017
1	AcetoneIBA 01/2016
1	Hydroxocobalamin FDA Link 01/2016
1	sodium thiosulfate FDA Link 01/2016
1	acetonitrileIBA 01/2016

Therapy/Procedure

21	Therapeutics 01/2023 - 06/2005
8	Artificial Respiration (Mechanical Ventilation) 12/2022 - 09/2007
5	Critical Care (Surgical Intensive Care) 01/2021 - 09/2007
3	Length of Stay 04/2023 - 09/2007
2	Extracorporeal Membrane Oxygenation 11/2023 - 01/2021
1	Parenteral Nutrition 09/2023
1	Antibiotic Prophylaxis 08/2022
1	Patient Discharge 01/2018
1	Duration of Therapy 01/2018
1	Drug Therapy (Chemotherapy) 09/2017