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Stefaan C De Smedt Selected Research

Neoplasms (Cancer)

4/2024Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria.
3/2024Nanomedicine to aid immunogenic cell death (ICD)-based anticancer therapy.
12/2023Considerations on the Design of Lipid-based mRNA Vaccines Against Cancer.
12/2023The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments.
11/2023Non-viral engineering of NK cells.
10/2023The effect of electrostatic high pressure nebulization on the stability, activity and ex vivo distribution of ionic self-assembled nanomedicines.
9/2023Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer.
10/2022A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs.
1/2022Non-viral siRNA delivery to T cells: Challenges and opportunities in cancer immunotherapy.
12/2021Exploring high pressure nebulization of Pluronic F127 hydrogels for intraperitoneal drug delivery.
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Stefaan C De Smedt Research Topics

Disease

37Neoplasms (Cancer)
04/2024 - 02/2008
7COVID-19
01/2024 - 10/2021
6Melanoma (Melanoma, Malignant)
12/2023 - 01/2010
6Peritoneal Neoplasms
06/2019 - 07/2014
4Retinal Diseases
01/2024 - 11/2008
4Neoplasm Metastasis (Metastasis)
10/2023 - 07/2020
4Ascites
01/2020 - 11/2015
4Rupture
01/2018 - 05/2009
3Hematologic Neoplasms (Hematological Malignancy)
02/2024 - 01/2022
3Inflammation (Inflammations)
10/2023 - 01/2022
3Infections
04/2021 - 09/2014
3Ovarian Neoplasms (Ovarian Cancer)
07/2020 - 01/2017
3Cystic Fibrosis (Mucoviscidosis)
06/2013 - 04/2002
2Communicable Diseases (Infectious Diseases)
12/2023 - 01/2021
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2023 - 01/2021
2Eye Diseases (Eye Disease)
06/2022 - 10/2005
2Wounds and Injuries (Trauma)
09/2021 - 08/2017
2Carcinoma (Carcinomatosis)
11/2010 - 03/2007
1Listeriosis (Listeria Infection)
04/2024
1Bacterial Infections (Bacterial Infection)
04/2024
1Skin Neoplasms (Skin Cancer)
12/2023
1Experimental Arthritis
11/2023
1Fibrosis (Cirrhosis)
10/2023
1Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
01/2022
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2022
1Respiratory Tract Infections (Respiratory Tract Infection)
01/2022
1Inborn Genetic Diseases (Disease, Hereditary)
01/2021
1Flushing
07/2020
1Pneumonia (Pneumonitis)
10/2019
1Glaucoma
08/2019
1Diabetic Retinopathy (Retinopathy, Diabetic)
08/2019

Drug/Important Bio-Agent (IBA)

16Small Interfering RNA (siRNA)IBA
12/2023 - 02/2008
15Messenger RNA (mRNA)IBA
04/2024 - 11/2010
6AntigensIBA
12/2023 - 12/2011
6Liposomes (Liposome)IBA
11/2023 - 04/2002
5mRNA VaccinesIBA
04/2024 - 10/2021
3VaccinesIBA
04/2024 - 01/2021
3HydrogelsIBA
10/2023 - 07/2021
3PolymersIBA
10/2023 - 07/2008
3AerosolsIBA
10/2023 - 06/2019
3Lipid NanoparticlesIBA
01/2023 - 11/2017
3DNA (Deoxyribonucleic Acid)IBA
01/2020 - 04/2002
3Biomarkers (Surrogate Marker)IBA
06/2016 - 01/2014
2Chimeric Antigen ReceptorsIBA
02/2024 - 07/2021
2LipidsIBA
12/2023 - 01/2021
2CholesterolIBA
09/2023 - 01/2016
2RNA (Ribonucleic Acid)IBA
10/2022 - 07/2008
2Surface-Active Agents (Surfactants)IBA
01/2022 - 05/2015
2Nucleic AcidsIBA
01/2022 - 01/2021
2FluorocarbonsIBA
01/2022 - 10/2019
2fluorescein isothiocyanate dextranIBA
07/2021 - 10/2003
2Proteins (Proteins, Gene)FDA Link
04/2021 - 11/2015
2Retinaldehyde (Retinal)IBA
01/2021 - 10/2005
2Contrast MediaIBA
10/2019 - 11/2017
2GoldIBA
01/2019 - 01/2018
2Cancer VaccinesIBA
01/2019 - 11/2014
21,2-distearoylphosphatidylethanolamine (DSPE)IBA
09/2017 - 01/2017
1alpha-galactosylceramideIBA
04/2024
1Melanins (Melanin)IBA
12/2023
1Prazosin (Minipress)FDA LinkGeneric
12/2023
1polyethylene glycol-poly(lactide-co-glycolide)IBA
10/2023
1Drug CombinationsIBA
09/2023
1Histamine Antagonists (Antihistamines)IBA
09/2023
1ebastine (Kestin)IBA
09/2023
1Advanced Glycation End ProductsIBA
06/2022
1Immune Checkpoint InhibitorsIBA
01/2022
1AntibodiesIBA
01/2022
1AutoantigensIBA
01/2022
1Biocompatible Materials (Biomaterials)IBA
01/2022
1FluorineIBA
01/2022
1Insulin (Novolin)FDA Link
01/2022
1Pulmonary Surfactants (Pulmonary Surfactant)IBA
01/2022
1Streptozocin (Streptozotocin)FDA Link
01/2022
1Glycoproteins (Glycoprotein)IBA
10/2021
1BNT162 VaccineIBA
10/2021
12019-nCoV Vaccine mRNA-1273IBA
10/2021
1BuffersIBA
09/2021
1Fluorescein (Funduscein)FDA LinkGeneric
07/2021
1isothiocyanic acidIBA
07/2021
1Photosensitizing Agents (Photosensitizers)IBA
07/2021
1GadoliniumIBA
06/2021
1InflammasomesIBA
04/2021
1Oxaliplatin (Eloxatin)FDA LinkGeneric
07/2020
1Hyaluronic Acid (Hyaluronan)IBA
07/2020
1polyarginineIBA
07/2020
1Cisplatin (Platino)FDA LinkGeneric
07/2020
1Cell ExtractsIBA
01/2020
1Antisense OligonucleotidesIBA
01/2020
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2019
1CollagenIBA
01/2019
1OvalbuminIBA
01/2019

Therapy/Procedure

24Therapeutics
03/2024 - 02/2008
10Immunotherapy
11/2023 - 12/2011
5Drug Therapy (Chemotherapy)
10/2023 - 10/2017
4Microbubbles
11/2014 - 01/2010
3Lasers (Laser)
12/2023 - 01/2018
2Cytoreduction Surgical Procedures
07/2020 - 10/2017
2Intravitreal Injections
11/2008 - 10/2005
1Phototherapy (Light Therapy)
12/2023
1Photothermal Therapy
12/2023