Ana De Jesus-Acosta Selected Research

Immunotherapy

1/2023	A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma.
1/2020	A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer.
6/2014	Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

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Ana De Jesus-Acosta Research Topics

Disease

18	Pancreatic Neoplasms (Pancreatic Cancer) 01/2023 - 01/2011
17	Adenocarcinoma 01/2023 - 01/2012
15	Neoplasms (Cancer) 01/2023 - 01/2011
3	Colorectal Neoplasms (Colorectal Cancer) 12/2022 - 12/2018
2	Neuroendocrine Tumors (Neuroendocrine Tumor) 04/2024 - 05/2021
2	Primitive Neuroectodermal Tumors (PNET) 04/2024 - 10/2022
2	Disease Progression 01/2020 - 02/2016
1	Turcot syndrome 12/2022
1	Clinical Deterioration 11/2021
1	Insulin Resistance 11/2021
1	Type 2 Diabetes Mellitus (MODY) 11/2021
1	Splenic Diseases 01/2021
1	Necrosis 01/2020
1	Microsatellite Instability 01/2020
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 12/2018
1	Adenosquamous Carcinoma 04/2015
1	Neoplasm Metastasis (Metastasis) 01/2011

Drug/Important Bio-Agent (IBA)

9	Gemcitabine FDA Link 01/2023 - 01/2011
5	Irinotecan (Camptosar)FDA LinkGeneric 01/2023 - 07/2017
5	Biomarkers (Surrogate Marker)IBA 11/2022 - 01/2011
3	Capecitabine (Xeloda)FDA Link 01/2023 - 02/2012
3	Cisplatin (Platino)FDA LinkGeneric 01/2023 - 07/2017
3	130-nm albumin-bound paclitaxelIBA 11/2022 - 07/2019
3	AntigensIBA 01/2021 - 01/2014
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2023 - 01/2020
2	Docetaxel (Taxotere)FDA Link 01/2023 - 02/2012
2	AntibodiesIBA 01/2023 - 11/2021
2	B7-H1 AntigenIBA 05/2021 - 01/2020
2	CarbohydratesIBA 01/2021 - 01/2014
2	pembrolizumabIBA 01/2020 - 01/2020
2	Mitomycin (Mitomycin-C)FDA LinkGeneric 07/2017 - 01/2011
1	trans-sodium crocetinate (crocetin)IBA 04/2024
1	GVAX vaccineIBA 01/2023
1	urelumabIBA 01/2023
1	NivolumabIBA 01/2023
1	Leucovorin (Folinic Acid)FDA Link 01/2023
1	Fluorouracil (Carac)FDA LinkGeneric 01/2023
1	Cell-Free Nucleic AcidsIBA 11/2022
1	TOR Serine-Threonine KinasesIBA 10/2022
1	Hemoglobins (Hemoglobin)IBA 11/2021
1	Insulin (Novolin)FDA Link 11/2021
1	Insulin AntibodiesIBA 11/2021
1	Insulin ReceptorIBA 11/2021
1	Blood Glucose (Blood Sugar)IBA 11/2021
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 05/2021
1	Immune Checkpoint ProteinsIBA 01/2020
1	VaccinesIBA 01/2020
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2020
1	Programmed Cell Death 1 ReceptorIBA 01/2020
1	Monoclonal AntibodiesIBA 01/2020
1	HhAntag691IBA 01/2020
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 07/2019
1	RNA (Ribonucleic Acid)IBA 01/2019
1	guadecitabineIBA 12/2018
1	Insulin-Like Growth Factor II (Somatomedin A)IBA 01/2018
1	Insulin-Like Growth Factor Binding Protein 2IBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018
1	MesothelinIBA 01/2018
1	Matrix Metalloproteinases (MMPs)IBA 01/2018
1	OsteopontinIBA 01/2018
1	olaparibIBA 07/2017
1	polyadenosineIBA 07/2017
1	PlatinumIBA 04/2015
1	2,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA 08/2014
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 08/2014
1	EnzymesIBA 08/2014
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 07/2013
1	ChromatinIBA 01/2012
1	Carrier Proteins (Binding Protein)IBA 01/2012
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2012
1	Fatty Acid-Binding ProteinsIBA 01/2012
1	Fanconi Anemia Complementation Group N ProteinIBA 01/2011
1	DNA (Deoxyribonucleic Acid)IBA 01/2011

Therapy/Procedure

13	Drug Therapy (Chemotherapy) 01/2023 - 02/2012
10	Therapeutics 01/2023 - 01/2011
3	Immunotherapy 01/2023 - 06/2014
3	Radiotherapy 01/2022 - 07/2013
3	Neoadjuvant Therapy 11/2021 - 12/2013
2	Combination Drug Therapy (Combination Chemotherapy) 01/2023 - 02/2016
1	Organ Transplantation 12/2022
1	Pancreaticoduodenectomy 11/2021
1	Glycemic Control 11/2021
1	Pancreatectomy 01/2021
1	Precision Medicine 01/2021
1	Adjuvant Chemotherapy 01/2021
1	Ligation 01/2018
1	Induction Chemotherapy 02/2016