Patricia A Darrah Selected Research

Vaccines

11/2023	Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis.
1/2023	Blood transcriptional correlates of BCG-induced protection against tuberculosis in rhesus macaques.
12/2021	Robust IgM responses following intravenous vaccination with Bacille Calmette-Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques.
1/2020	Prevention of tuberculosis in macaques after intravenous BCG immunization.
1/2019	Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques.
1/2018	Toward Tuberculosis Vaccine Development: Recommendations for Nonhuman Primate Study Design.
8/2015	Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates.
3/2015	Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling.
8/2014	Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.
1/2014	A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs.

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Patricia A Darrah Research Topics

Disease

10	Tuberculosis (Tuberculoses) 11/2023 - 06/2009
9	Infections 01/2020 - 08/2004
3	Pulmonary Tuberculosis 11/2023 - 08/2014
2	Neoplasms (Cancer) 12/2023 - 08/2015
2	Communicable Diseases (Infectious Diseases) 08/2015 - 01/2015
1	Virus Diseases (Viral Diseases) 12/2023
1	Hypoxia (Hypoxemia) 07/2023
1	Granuloma 01/2023
1	Malaria 03/2015
1	Bites and Stings (Sting) 03/2015
1	Leishmaniasis 11/2010

Drug/Important Bio-Agent (IBA)

13	VaccinesIBA 11/2023 - 04/2008
3	AntigensIBA 01/2023 - 03/2015
1	Toll-Like Receptor AgonistsIBA 12/2023
1	Tuberculin (PPD)IBA 07/2023
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2023
1	Immunoglobulin M (IgM)IBA 12/2021
1	BCG Vaccine FDA Link 01/2020
1	AerosolsIBA 01/2019
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2014
1	Synthetic Vaccines (Recombinant Vaccines)IBA 03/2013
1	SB 203580IBA 11/2010
1	p38 Mitogen-Activated Protein KinasesIBA 11/2010
1	InterleukinsIBA 07/2010
1	Subunit VaccinesIBA 06/2009
1	Interleukin-2 (IL2)IBA 07/2007
1	Interferon-gamma (Interferon, gamma)IBA 07/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2007
1	NF-kappa B (NF-kB)IBA 08/2004
1	CytokinesIBA 08/2004
1	Interleukin-12 (IL 12)IBA 08/2004

Therapy/Procedure

2	Therapeutics 01/2015 - 01/2014
1	Immunotherapy 12/2023
1	Intravenous Administration 01/2020