Lenny Dang Selected Research

Uridine

12/2020

Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.

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Lenny Dang Research Topics

Disease

22	Neoplasms (Cancer) 10/2021 - 05/2002
7	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2021 - 02/2010
4	Lymphoma (Lymphomas) 12/2020 - 01/2005
4	Glioblastoma (Glioblastoma Multiforme) 01/2017 - 02/2010
4	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 09/2010 - 01/2005
3	Anemia 10/2023 - 09/2017
3	Multiple Myeloma 08/2007 - 05/2002
2	Iron Overload 01/2023 - 01/2021
2	Sickle Cell Anemia (Hemoglobin S Disease) 11/2022 - 01/2021
2	Pyruvate Kinase Deficiency of Red Cells 01/2021 - 01/2017
2	Hematologic Neoplasms (Hematological Malignancy) 12/2020 - 01/2017
2	Glioma (Gliomas) 02/2020 - 02/2010
2	Carcinogenesis 01/2017 - 10/2012
1	Hereditary Spherocytosis 10/2023
1	Headache (Headaches) 11/2022
1	Sleep Initiation and Maintenance Disorders (Insomnia) 11/2022
1	Hypertension (High Blood Pressure) 11/2022
1	Leukocytosis (Pleocytosis) 01/2022
1	Thalassemia 01/2021
1	Hemolysis 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Starvation 12/2020
1	Chondrosarcoma 01/2017
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2017
1	Cholangiocarcinoma 01/2017
1	Hemolytic Anemia 01/2017
1	2-Hydroxyglutaricaciduria 11/2016
1	Cardiomyopathies (Cardiomyopathy) 11/2016
1	Acute Erythroblastic Leukemia (Erythroleukemia) 05/2013
1	Brain Neoplasms (Brain Tumor) 12/2009
1	Disease Progression 09/2006
1	Prostatic Neoplasms (Prostate Cancer) 09/2006
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2005

Drug/Important Bio-Agent (IBA)

10	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 10/2021 - 12/2009
10	EnzymesIBA 01/2021 - 12/2009
8	mitapivatIBA 10/2023 - 01/2017
7	Pyruvate KinaseIBA 01/2023 - 10/2012
7	alpha-hydroxyglutarateIBA 10/2021 - 12/2009
7	NF-kappa B (NF-kB)IBA 09/2010 - 05/2002
4	Adenosine Triphosphate (ATP)IBA 01/2022 - 09/2017
4	I-kappa B KinaseIBA 12/2008 - 01/2005
3	ivosidenibIBA 10/2021 - 04/2018
3	isocitric acid (isocitrate)IBA 01/2017 - 09/2010
3	Interleukin-6 (Interleukin 6)IBA 04/2008 - 09/2006
2	2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)IBA 01/2022 - 09/2017
2	5'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)IBA 01/2021 - 01/2021
2	Methionine AdenosyltransferaseIBA 01/2021 - 01/2021
2	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 12/2020 - 09/2010
2	Oxidoreductases (Dehydrogenase)IBA 01/2017 - 05/2013
2	Glucose (Dextrose)FDA LinkGeneric 10/2012 - 09/2012
2	Biomarkers (Surrogate Marker)IBA 09/2010 - 09/2006
2	NADP (NADPH)IBA 09/2010 - 12/2009
2	Ketoglutaric Acids (Ketoglutaric Acid)IBA 09/2010 - 12/2009
2	CytokinesIBA 10/2006 - 05/2002
1	Sickle HemoglobinIBA 11/2022
1	Hemoglobins (Hemoglobin)IBA 01/2022
1	Erythropoietin FDA Link 01/2021
1	S-Adenosylmethionine (Ademetionine)IBA 01/2021
1	IronIBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	Cyclin-Dependent Kinase Inhibitor p16IBA 01/2021
1	Dihydroorotate DehydrogenaseIBA 12/2020
1	pyrimidineIBA 12/2020
1	UridineIBA 12/2020
1	vorasidenibIBA 02/2020
1	Arginine (L-Arginine)FDA Link 04/2018
1	enasidenibIBA 01/2017
1	Thyroid Hormone-Binding ProteinsIBA 09/2014
1	Oxygen (Dioxygen)IBA 09/2014
1	GlutaminaseIBA 09/2014
1	IsoenzymesIBA 09/2014
1	AGI-6780IBA 05/2013
1	Protein Isoforms (Isoforms)IBA 10/2012
1	Amino Acids FDA Link 09/2012
1	Serine (L-Serine)FDA Link 09/2012
1	pevonedistatIBA 09/2010
1	DNA (Deoxyribonucleic Acid)IBA 09/2010
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 10/2008
1	Interleukin-10 (Interleukin 10)IBA 04/2008
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 04/2008
1	Melphalan (Alkeran)FDA LinkGeneric 10/2006
1	Dexamethasone (Maxidex)FDA LinkGeneric 10/2006
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2006
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2006
1	Insulin-Like Growth Factor I (IGF-1)IBA 10/2006
1	Hormones (Hormone)IBA 09/2006
1	PS1145IBA 09/2006
1	Docetaxel (Taxotere)FDA Link 09/2006
1	Aligeron (AS 2)IBA 05/2002
1	Thalidomide (Thalomid)FDA Link 05/2002
1	Immunomodulating AgentsIBA 05/2002
1	Bortezomib (Velcade)FDA Link 05/2002
1	Proteasome InhibitorsIBA 05/2002

Therapy/Procedure

7	Therapeutics 01/2021 - 10/2006
1	Splenectomy 10/2023
1	Drug Therapy (Chemotherapy) 10/2021