Rosanne M Crooke Selected Research

Non-alcoholic Fatty Liver Disease

10/2019	Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.
10/2013	The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.
4/2012	Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice.
5/2007	Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.

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Rosanne M Crooke Research Topics

Disease

19	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 05/2005
11	Atherosclerosis 01/2022 - 02/2006
9	Insulin Resistance 01/2017 - 12/2006
8	Inflammation (Inflammations) 01/2016 - 02/2009
6	Hypertriglyceridemia 01/2022 - 12/2006
6	Obesity 10/2019 - 12/2006
4	Non-alcoholic Fatty Liver Disease 10/2019 - 05/2007
3	Hypercholesterolemia 01/2022 - 08/2006
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 06/2011
3	Hyperlipidemias (Hyperlipidemia) 01/2021 - 05/2005
3	Fibrosis (Cirrhosis) 10/2019 - 02/2009
3	Type 2 Diabetes Mellitus (MODY) 01/2017 - 05/2013
3	Myocardial Infarction 11/2016 - 01/2014
3	Aortic Valve Stenosis (Aortic Stenosis) 11/2016 - 10/2015
3	Dyslipidemias (Dyslipidemia) 08/2016 - 12/2006
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2013 - 05/2011
3	Hepatomegaly 09/2010 - 05/2008
3	Liver Diseases (Liver Disease) 09/2010 - 05/2008
2	Hepatitis 10/2019 - 01/2017
2	Hypertension (High Blood Pressure) 01/2019 - 01/2017
2	Acute Kidney Injury (Acute Renal Failure) 10/2018 - 01/2017
2	Fatty Liver 01/2017 - 02/2016
2	Body Weight (Weight, Body) 02/2016 - 04/2012
2	Pancreatitis 07/2015 - 12/2014
2	Coronary Disease (Coronary Heart Disease) 05/2013 - 07/2005
2	Disease Progression 09/2011 - 06/2011
1	Atherosclerotic Plaque (Atheroma) 01/2022
1	Hyperglycemia 11/2019
1	Liver Cirrhosis (Hepatic Cirrhosis) 10/2019
1	Alcoholic Fatty Liver 10/2019
1	Chronic Renal Insufficiency 10/2018
1	Headache (Headaches) 01/2017
1	Dizziness (Lightheadedness) 01/2017
1	Injection Site Reaction 11/2016
1	Stroke (Strokes) 03/2016
1	Peripheral Arterial Disease 03/2016
1	Virus Diseases (Viral Diseases) 02/2016

Drug/Important Bio-Agent (IBA)

17	Antisense OligonucleotidesIBA 01/2022 - 08/2006
15	Triglycerides (Triacylglycerol)IBA 01/2022 - 07/2005
12	LipidsIBA 01/2022 - 05/2007
12	CholesterolIBA 01/2022 - 05/2008
8	Insulin (Novolin)FDA Link 01/2022 - 12/2006
8	ApolipoproteinsIBA 11/2019 - 05/2005
7	Apolipoprotein C-IIIIBA 01/2022 - 06/2011
6	Messenger RNA (mRNA)IBA 01/2017 - 05/2011
5	LDL CholesterolIBA 01/2022 - 07/2005
5	Lipoproteins (Lipoprotein)IBA 11/2019 - 08/2006
4	trimethyloxamine (trimethylamine N-oxide)IBA 01/2017 - 01/2015
4	dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA 01/2017 - 01/2015
4	EnzymesIBA 01/2017 - 05/2008
4	Glucose (Dextrose)FDA LinkGeneric 08/2016 - 05/2007
4	LDL Receptors (LDL Receptor)IBA 02/2016 - 08/2006
4	Apolipoproteins B (ApoB)IBA 05/2011 - 05/2005
3	Proteins (Proteins, Gene)FDA Link 01/2017 - 05/2007
3	Lipoprotein(a)IBA 11/2016 - 10/2015
3	C-Reactive ProteinIBA 01/2014 - 11/2012
3	oxidized low density lipoproteinIBA 10/2006 - 05/2005
2	AcyltransferasesIBA 10/2019 - 08/2006
2	microsomal triglyceride transfer proteinIBA 01/2017 - 03/2014
2	O(4)-methylthymidine triphosphateIBA 01/2017 - 03/2014
2	ISIS 304801IBA 08/2016 - 12/2014
2	ISIS-APO(a)RxIBA 03/2016 - 10/2015
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2016 - 03/2014
2	Oxidoreductases (Dehydrogenase)IBA 06/2012 - 05/2011
2	Fatty Acids (Saturated Fatty Acids)IBA 04/2012 - 05/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2010 - 02/2009
2	GlycosphingolipidsIBA 09/2010 - 05/2008
2	Sterol O-AcyltransferaseIBA 04/2008 - 08/2006
1	Ezetimibe (Zetia)FDA Link 01/2022
1	Steroid 12-alpha-Hydroxylase (CYP8B1)IBA 01/2022
1	Simvastatin (Zocor)FDA LinkGeneric 01/2022
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022
1	Bile Acids and Salts (Bile Acids)IBA 01/2022
1	Insulin ReceptorIBA 01/2022
1	Angiopoietin-Like Protein 3IBA 01/2021
1	RNA (Ribonucleic Acid)IBA 10/2018
1	AngiotensinogenIBA 01/2017
1	Fatty Acid-Binding ProteinsIBA 01/2017
1	Carrier Proteins (Binding Protein)IBA 01/2017
1	Captopril (Capoten)FDA LinkGeneric 01/2017
1	Losartan (Cozaar)FDA LinkGeneric 01/2017
1	OligonucleotidesIBA 01/2017
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2017
1	VLDL LipoproteinsIBA 01/2017
1	FructoseIBA 01/2017
1	SaltsIBA 01/2017
1	AcetylgalactosamineIBA 01/2017
1	AcidsIBA 01/2017
1	Apolipoproteins AIBA 11/2016
1	AKCEA-APO(a)-LRxIBA 11/2016
1	FructosamineIBA 08/2016
1	AlbuminsIBA 08/2016
1	Angiotensin IIBA 02/2016
1	aliskiren FDA Link 02/2016
1	Angiotensin IIIBA 02/2016
1	Renin InhibitorsIBA 02/2016

Therapy/Procedure

6	Therapeutics 01/2019 - 10/2013
1	Glycemic Control 01/2022
1	Injections 11/2016
1	Aftercare (After-Treatment) 08/2016