Massimo Cristofanilli Selected Research

Chemokine Receptors

1/2022	CCR5 activation and endocytosis in circulating tumor-derived cells isolated from the blood of breast cancer patients provide information about clinical outcome.
1/2018	CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion.
9/2017	Phase Ib Pilot Study to Evaluate Reparixin in Combination with Weekly Paclitaxel in Patients with HER-2-Negative Metastatic Breast Cancer.
10/2015	A Preclinical Model of Inflammatory Breast Cancer to Study the Involvement of CXCR4 and ACKR3 in the Metastatic Process.
6/2007	Manipulating the chemokine-chemokine receptor network to treat cancer.

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Massimo Cristofanilli Research Topics

Disease

187	Breast Neoplasms (Breast Cancer) 03/2024 - 04/2002
160	Neoplasms (Cancer) 03/2024 - 10/2002
43	Neoplasm Metastasis (Metastasis) 04/2023 - 10/2002
40	Inflammatory Breast Neoplasms 01/2023 - 02/2004
35	Circulating Neoplastic Cells 01/2024 - 03/2005
19	Triple Negative Breast Neoplasms 05/2023 - 03/2008
14	Disease Progression 03/2023 - 04/2002
10	Pathologic Complete Response 10/2013 - 06/2005
9	Neutropenia 01/2021 - 05/2012
5	Carcinoma (Carcinomatosis) 01/2023 - 04/2003
5	Prostatic Neoplasms (Prostate Cancer) 01/2018 - 01/2003
4	Febrile Neutropenia 01/2021 - 07/2015
4	Infections 01/2021 - 05/2012
4	Lung Neoplasms (Lung Cancer) 06/2019 - 08/2008
4	Anemia 09/2018 - 11/2014
3	Lobular Carcinoma 12/2022 - 01/2005
3	Carcinogenesis 12/2020 - 12/2014
3	Exanthema (Rash) 01/2020 - 11/2016
3	Fatigue 01/2020 - 07/2015
3	Pleural Effusion (Pleural Effusions) 10/2016 - 06/2010
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2024 - 01/2020
2	Brain Neoplasms (Brain Tumor) 01/2023 - 09/2019
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2021 - 11/2017
2	Diarrhea 01/2020 - 11/2016
2	Noninfiltrating Intraductal Carcinoma (DCIS) 08/2019 - 10/2016
2	Thrombocytopenia (Thrombopenia) 09/2018 - 07/2015
2	Hypothyroidism 01/2017 - 06/2009
2	Leukopenia 01/2017 - 07/2015

Drug/Important Bio-Agent (IBA)

55	Hormones (Hormone)IBA 03/2024 - 01/2004
37	Biomarkers (Surrogate Marker)IBA 01/2024 - 12/2006
30	palbociclibIBA 03/2024 - 07/2015
29	Estrogen ReceptorsIBA 10/2023 - 02/2004
24	Circulating Tumor DNAIBA 01/2024 - 01/2013
23	ErbB Receptors (EGF Receptor)IBA 03/2024 - 06/2005
18	Proteins (Proteins, Gene)FDA Link 10/2022 - 02/2003
16	Fulvestrant (Faslodex)FDA Link 03/2024 - 07/2015
14	Paclitaxel (Taxol)FDA LinkGeneric 01/2023 - 02/2004
12	human ERBB2 proteinIBA 01/2023 - 06/2005
12	AnthracyclinesIBA 01/2012 - 04/2002
11	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2018 - 01/2003
10	Cyclin-Dependent Kinase 4IBA 03/2024 - 01/2017
10	Cell-Free Nucleic AcidsIBA 11/2021 - 10/2016
9	Progesterone Receptors (Progesterone Receptor)IBA 01/2023 - 12/2006
9	DNA (Deoxyribonucleic Acid)IBA 12/2022 - 05/2016
9	Docetaxel (Taxotere)FDA Link 12/2018 - 04/2002
8	Trastuzumab (Herceptin)FDA Link 09/2018 - 04/2002
7	Messenger RNA (mRNA)IBA 01/2023 - 09/2005
7	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/2013 - 07/2003
6	Cyclin-Dependent Kinases (cdk Proteins)IBA 03/2024 - 10/2006
6	Aromatase InhibitorsIBA 03/2024 - 01/2004
6	Estrogens (Estrogen)FDA Link 04/2013 - 07/2003
6	Taxoids (Taxanes)IBA 01/2012 - 05/2002
6	Fluorouracil (Carac)FDA LinkGeneric 03/2010 - 05/2002
5	Epidermal Growth Factor (EGF)IBA 03/2023 - 06/2010
5	Immune Checkpoint InhibitorsIBA 05/2022 - 01/2017
5	Chemokine ReceptorsIBA 01/2022 - 06/2007
5	AntibodiesIBA 01/2021 - 01/2003
4	Tumor Biomarkers (Tumor Markers)IBA 01/2024 - 10/2002
4	LigandsIBA 04/2023 - 07/2004
4	Epithelial Cell Adhesion MoleculeIBA 01/2022 - 06/2009
4	Monoclonal AntibodiesIBA 01/2021 - 02/2003
4	Phenobarbital (Luminal)FDA Link 11/2020 - 08/2005
4	Peptides (Polypeptides)IBA 01/2020 - 01/2003
4	taxaneIBA 09/2018 - 09/2003
4	Cadherins (E-Cadherin)IBA 04/2016 - 12/2006
4	Lapatinib (GW572016)FDA Link 01/2013 - 06/2010
4	Transcription Factors (Transcription Factor)IBA 11/2012 - 12/2005
3	RNA (Ribonucleic Acid)IBA 01/2022 - 06/2019
3	ChemokinesIBA 01/2022 - 06/2007
3	Tamoxifen FDA LinkGeneric 01/2020 - 05/2005
3	AntigensIBA 01/2018 - 02/2007
3	MicroRNAs (MicroRNA)IBA 01/2018 - 07/2010
3	Anastrozole (Arimidex)FDA LinkGeneric 11/2016 - 03/2010
3	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 08/2010 - 02/2009
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 06/2010 - 01/2008
3	ParaffinIBA 05/2005 - 11/2003
2	Immunoconjugates (Immunoconjugate)IBA 01/2023 - 05/2022
2	Phosphotransferases (Kinase)IBA 01/2022 - 01/2021
2	Letrozole (Femara)FDA LinkGeneric 01/2021 - 01/2020
2	CytokinesIBA 01/2021 - 08/2019
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2020 - 01/2020
2	Capecitabine (Xeloda)FDA Link 01/2020 - 06/2010
2	CyclinsIBA 10/2019 - 01/2019
2	exemestane (Aromasin)FDA Link 01/2019 - 01/2016
2	Antineoplastic Agents (Antineoplastics)IBA 12/2018 - 10/2013
2	EnzymesIBA 09/2018 - 09/2009
2	Thymidine KinaseIBA 01/2018 - 11/2016
2	Anaplastic Lymphoma KinaseIBA 01/2018 - 01/2013
2	Genetic Markers (Genetic Marker)IBA 06/2017 - 10/2014
2	Cell Surface ReceptorsIBA 11/2016 - 05/2005
2	AZD 8931IBA 11/2016 - 05/2014

Therapy/Procedure

121	Therapeutics 03/2024 - 04/2002
44	Drug Therapy (Chemotherapy) 03/2023 - 04/2002
19	Neoadjuvant Therapy 01/2024 - 04/2003
11	Radiotherapy 01/2018 - 02/2004
8	Precision Medicine 12/2022 - 11/2016
6	Immunotherapy 03/2024 - 01/2018
4	Drug Tapering 12/2020 - 05/2012
4	Segmental Mastectomy (Lumpectomy) 01/2018 - 09/2004
3	Mastectomy (Mammectomy) 10/2016 - 09/2004