Diane Crighton Selected Research

Neoplasms (Cancer)

1/2018	Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
9/2016	p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death.
11/2015	LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.
10/2014	A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
5/2013	Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53.
1/2011	Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
1/2011	Trailblazing LIM kinases take the lead in collective tumor cell invasion.
10/2010	LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.
4/2007	A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.
1/2007	DRAM links autophagy to p53 and programmed cell death.

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Diane Crighton Research Topics

Disease

13	Neoplasms (Cancer) 01/2018 - 05/2002
4	Myotonic Dystrophy (Dystrophia Myotonica) 11/2018 - 01/2011
2	Neoplasm Metastasis (Metastasis) 10/2014 - 12/2011
1	Skin Neoplasms (Skin Cancer) 01/2018
1	Breast Neoplasms (Breast Cancer) 10/2014
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2014
1	Hypoxia (Hypoxemia) 05/2013
1	Li-Fraumeni Syndrome 05/2002

Drug/Important Bio-Agent (IBA)

4	Phosphotransferases (Kinase)IBA 11/2018 - 01/2011
3	Myosins (Myosin)IBA 11/2018 - 10/2014
3	Lim KinasesIBA 11/2015 - 10/2010
3	Proteins (Proteins, Gene)FDA Link 10/2014 - 01/2007
2	Small Interfering RNA (siRNA)IBA 01/2011 - 10/2010
2	Transcription Factors (Transcription Factor)IBA 01/2007 - 06/2003
1	BDP9066IBA 01/2018
1	Therapeutic UsesIBA 01/2018
1	Glycoside Hydrolases (Endoglycosidases)IBA 09/2016
1	Drug CombinationsIBA 11/2015
1	Y 27632IBA 10/2014
1	CollagenIBA 10/2014
1	4- chloro- 1- (4- piperidyl)- N- (5- (2- pyridyl)- 1H- pyrazol- 4- yl)pyrazole- 3- carboxamideIBA 10/2014
1	matrigelIBA 10/2014
1	Adenosine (Adenocard)FDA LinkGeneric 05/2013
1	ActomyosinIBA 01/2011
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2011
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2011
1	Peptides (Polypeptides)IBA 04/2007
1	DNA (Deoxyribonucleic Acid)IBA 12/2004
1	RNA Polymerase IIIIBA 05/2002
1	Oncogene Proteins (Oncogene Protein)IBA 05/2002

Therapy/Procedure

4	Therapeutics 09/2016 - 05/2013