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Linda B Couto Selected Research

Factor IX (Coagulation Factor IX)

12/2017Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.
6/2010Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B.
3/2006Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice.
5/2005Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model.
1/2004Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1.
4/2003AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.
7/2002Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy.

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Linda B Couto Research Topics

Disease

7Hemophilia B (Haemophilia B)
12/2017 - 07/2002
6Hemophilia A (Haemophilia)
12/2017 - 09/2003
2Hemorrhage
12/2017 - 05/2005
1Body Weight (Weight, Body)
12/2017
1Infections
03/2013
1Liver Diseases (Liver Disease)
06/2010

Drug/Important Bio-Agent (IBA)

7Factor IX (Coagulation Factor IX)FDA LinkGeneric
12/2017 - 07/2002
4Factor VIII (Coagulation Factor VIII)IBA
07/2006 - 09/2003
2Blood Coagulation Factors (Coagulation Factor)IBA
12/2017 - 10/2003
2Proteins (Proteins, Gene)FDA Link
07/2006 - 09/2003
1factor IX-PaduaIBA
12/2017
1prothrombin complex concentrates (PPSB)IBA
12/2017
1CoagulantsIBA
12/2017
1MicroRNAs (MicroRNA)IBA
03/2013
1N-acetyltalosaminuronic acid (NAT)IBA
07/2002

Therapy/Procedure

2Therapeutics
06/2010 - 07/2006
2Intramuscular Injections
04/2003 - 07/2002
1Immunomodulation
11/2006