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Roberto Coppari Selected Research

Body Weight (Weight, Body)

9/2012Leptin revisited: its mechanism of action and potential for treating diabetes.
3/2012Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.
1/2011A treasure trove of hypothalamic neurocircuitries governing body weight homeostasis.
10/2010Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice.
12/2009Central administration of resveratrol improves diet-induced diabetes.
5/2008Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
4/2008Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.
1/2006Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.
12/2005Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis.
12/2005Mice lacking ghrelin receptors resist the development of diet-induced obesity.
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Roberto Coppari Research Topics

Disease

14Obesity
11/2020 - 12/2005
12Body Weight (Weight, Body)
09/2012 - 06/2004
11Insulin Resistance
01/2023 - 08/2006
6Hyperglycemia
01/2024 - 12/2009
5Type 2 Diabetes Mellitus (MODY)
02/2014 - 09/2007
4Neoplasms (Cancer)
12/2023 - 06/2005
3Inflammation (Inflammations)
01/2024 - 01/2012
3Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2024 - 10/2010
2Hypoglycemia (Reactive Hypoglycemia)
01/2024 - 01/2019
2Hypertrophy
11/2020 - 01/2012
2Hyperinsulinism (Hyperinsulinemia)
12/2009 - 01/2005
2Hyperphagia (Overeating)
04/2008 - 07/2006
2Weight Gain
04/2008 - 08/2006
1Tuberous Sclerosis (Bourneville's Disease)
01/2022
1Starvation
01/2021
1Metabolic Syndrome (Dysmetabolic Syndrome X)
11/2020
1Cardiovascular Diseases (Cardiovascular Disease)
06/2020
1Metabolic Diseases (Metabolic Disease)
01/2019
1Hypertriglyceridemia
01/2019
1Lipodystrophy
09/2012
1Dyslipidemias (Dyslipidemia)
03/2012
1Malnutrition (Nutritional Deficiencies)
03/2011
1Polyuria
10/2010
1Hypersensitivity (Allergy)
07/2010
1Fever (Fevers)
09/2007
1Mitochondrial Diseases (Mitochondrial Disease)
12/2006
1Weight Loss (Weight Reduction)
08/2006
1Carcinoma (Carcinomatosis)
06/2005

Drug/Important Bio-Agent (IBA)

12Insulin (Novolin)FDA Link
01/2024 - 12/2006
12LeptinIBA
01/2019 - 06/2004
11Glucose (Dextrose)FDA LinkGeneric
01/2024 - 12/2005
10Pro-Opiomelanocortin (Proopiomelanocortin)IBA
03/2012 - 06/2004
4Proteins (Proteins, Gene)FDA Link
11/2020 - 12/2009
4Sirtuin 1IBA
04/2012 - 10/2008
3SirtuinsIBA
12/2023 - 11/2015
3Triglycerides (Triacylglycerol)IBA
09/2012 - 12/2006
2Histone Deacetylases (Histone Deacetylase)IBA
12/2023 - 01/2017
2Fatty Acids (Saturated Fatty Acids)IBA
11/2020 - 01/2019
2Steroidogenic Factor 1IBA
11/2018 - 09/2011
2Hormones (Hormone)IBA
02/2014 - 01/2011
2Hypoglycemic Agents (Hypoglycemics)IBA
09/2012 - 12/2009
2NAD (NADH)IBA
04/2012 - 07/2010
2Blood Glucose (Blood Sugar)IBA
03/2012 - 01/2005
1Calcium-Binding ProteinsIBA
01/2024
1Toll-Like Receptors (Toll-Like Receptor)IBA
01/2024
1Mechanistic Target of Rapamycin Complex 1IBA
01/2022
1Essential Amino AcidsIBA
11/2020
1Amino AcidsFDA Link
11/2020
1Uncoupling Protein 1IBA
11/2020
1Peptidylprolyl Isomerase (Prolyl Isomerase)IBA
01/2020
1Tacrolimus Binding Proteins (FKBP)IBA
01/2020
1A-factor (Streptomyces)IBA
01/2019
1Protein Isoforms (Isoforms)IBA
11/2018
1LipidsIBA
11/2018
1Protein Tyrosine PhosphatasesIBA
11/2017
1NeuropeptidesIBA
01/2011
1Insulin ReceptorIBA
04/2010
1Pyruvic Acid (Pyruvate)IBA
12/2009
1Messenger RNA (mRNA)IBA
12/2009
1ResveratrolIBA
12/2009
1PhosphoenolpyruvateIBA
12/2009
1Mitochondrial Proteins (Mitochondrial Protein)IBA
09/2007
1Uncoupling Protein 2IBA
09/2007
1Adenosine Triphosphate (ATP)IBA
09/2007
1Dinoprostone (PGE2)FDA Link
09/2007
1Prostaglandin Receptors (Prostaglandin Receptor)IBA
09/2007
1KATP ChannelsIBA
07/2006
1Tolbutamide (Orinase)FDA LinkGeneric
07/2006
1Ghrelin ReceptorsIBA
12/2005
1GhrelinIBA
12/2005
1DisintegrinsIBA
06/2005
1EnzymesIBA
06/2005
1IntegrinsIBA
06/2005
1Leptin ReceptorsIBA
06/2004

Therapy/Procedure

7Therapeutics
01/2024 - 10/2010
1Diet Therapy (Therapy, Diet)
03/2011
1Intraventricular Infusions
12/2009