Gregory J Cooney Selected Research

Lipids

4/2024	Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice.
11/2022	Insulin sensitivity is preserved in mice made obese by feeding a high starch diet.
1/2019	Glucose mediates insulin sensitivity via a hepatoportal mechanism in high-fat-fed rats.
1/2018	High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.
10/2017	Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains.
7/2014	PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis.
7/2014	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.
12/2013	Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle.
1/2012	Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.
7/2009	Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation.

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Gregory J Cooney Research Topics

Disease

59	Insulin Resistance 04/2024 - 02/2002
15	Obesity 11/2022 - 01/2002
14	Type 2 Diabetes Mellitus (MODY) 11/2022 - 10/2002
10	Glucose Intolerance 04/2024 - 12/2004
7	Metabolic Diseases (Metabolic Disease) 04/2023 - 10/2006
6	Hyperinsulinism (Hyperinsulinemia) 09/2023 - 07/2009
5	Hyperglycemia 01/2018 - 03/2006
4	Fatty Liver 04/2024 - 03/2003
3	Body Weight (Weight, Body) 03/2016 - 04/2005
3	Lymphoma (Lymphomas) 12/2006 - 11/2004
2	Hypertrophy 01/2022 - 01/2007
2	Sarcopenia 12/2020 - 01/2018
2	Weight Gain 10/2019 - 11/2012
2	Hyperphagia (Overeating) 01/2019 - 01/2002
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2012 - 06/2008
1	Morbid Obesity 01/2018
1	Carcinogenesis 01/2017
1	Inflammation (Inflammations) 07/2015
1	Liver Neoplasms (Liver Cancer) 07/2014
1	Mason-Type Diabetes 01/2013
1	Thinness 01/2010
1	Weight Loss (Weight Reduction) 01/2010
1	Hyperlipidemias (Hyperlipidemia) 07/2009

Drug/Important Bio-Agent (IBA)

36	Insulin (Novolin)FDA Link 09/2023 - 05/2002
29	Glucose (Dextrose)FDA LinkGeneric 04/2024 - 12/2002
20	LipidsIBA 04/2024 - 05/2002
14	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 12/2002
11	Proteins (Proteins, Gene)FDA Link 04/2024 - 11/2003
9	EnzymesIBA 01/2022 - 11/2003
8	Triglycerides (Triacylglycerol)IBA 01/2018 - 03/2003
5	CeramidesIBA 11/2022 - 07/2009
4	GlycogenIBA 01/2015 - 01/2007
4	Acyl Coenzyme A (Acyl CoA)IBA 03/2009 - 02/2002
3	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 12/2004
3	AMP-Activated Protein KinasesIBA 01/2015 - 03/2006
3	Nonesterified Fatty Acids (NEFA)IBA 06/2008 - 12/2002
2	Starch (Cornstarch)IBA 04/2024 - 11/2022
2	ProteomeIBA 04/2024 - 01/2017
2	NAD (NADH)IBA 01/2023 - 01/2022
2	Sirtuin 3IBA 01/2023 - 01/2022
2	Blood Glucose (Blood Sugar)IBA 10/2021 - 02/2014
2	CytokinesIBA 10/2019 - 08/2014
2	Coenzyme A (CoA)IBA 11/2017 - 11/2003
2	DiglyceridesIBA 10/2017 - 03/2006
2	AntioxidantsIBA 01/2017 - 09/2012
2	Acetyl-CoA CarboxylaseIBA 07/2014 - 03/2006
2	Phosphotransferases (Kinase)IBA 02/2008 - 03/2006
2	Insulin Receptor Substrate ProteinsIBA 01/2007 - 12/2002
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2007 - 12/2002
2	Ligases (Synthetase)IBA 12/2006 - 03/2006
2	PPAR alphaIBA 07/2004 - 03/2003
1	Perilipin-5IBA 04/2024
1	Lipase (Acid Lipase)FDA Link 04/2024
1	NexusIBA 04/2023
1	Thiostrepton (Gargon)IBA 01/2023
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2023
1	CarbohydratesIBA 11/2022
1	mitochondrial uncoupler BAM15IBA 01/2020
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020
1	Oxidants (Oxidizing Agents)IBA 01/2020
1	Therapeutic UsesIBA 10/2019
1	Ciliary Neurotrophic Factor (CNTF)IBA 10/2019
1	Interleukin-6 (Interleukin 6)IBA 10/2019
1	Serotonin (5 Hydroxytryptamine)IBA 01/2019
1	Branched-Chain Amino AcidsIBA 01/2019
1	Amino Acids FDA Link 01/2019
1	dihydroceramide desaturaseIBA 01/2018
1	N-palmitoylsphingosineIBA 11/2017
1	UbiquitinIBA 01/2017
1	Sucrose (Saccharose)IBA 01/2017
1	CarbonIBA 01/2017
1	SphingolipidsIBA 11/2016
1	SphingomyelinsIBA 11/2016
1	AdipokinesIBA 07/2015
1	Leucine (L-Leucine)FDA Link 01/2015
1	Sirtuin 1IBA 01/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2014
1	Monoclonal AntibodiesIBA 08/2014
1	TransglutaminasesIBA 01/2013
1	OsteocalcinIBA 11/2012
1	CorticosteroneIBA 11/2012
1	GlucocorticoidsIBA 11/2012
1	Superoxide DismutaseIBA 09/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2012
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 06/2011
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 06/2011
1	Stearoyl-CoA DesaturaseIBA 06/2011
1	Hormones (Hormone)IBA 01/2010
1	AdiponectinIBA 01/2010
1	Glycerol (Glycerine)FDA LinkGeneric 07/2009
1	Carnitine (L-Carnitine)FDA LinkGeneric 03/2009
1	salicylhydroxamic acid (SHAM)IBA 03/2009
1	Calcium-Calmodulin-Dependent Protein Kinase KinaseIBA 05/2008
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 05/2008
1	Rosiglitazone (Avandia)FDA Link 05/2008
1	BerberineIBA 05/2008

Therapy/Procedure

2	Therapeutics 01/2023 - 05/2008
1	Drug Therapy (Chemotherapy) 01/2020
1	Transplantation 07/2015
1	Fat-Restricted Diet (Diet, Fat Restricted) 11/2009