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Kevin R Coombes Selected Research

Methyltransferases

1/2017Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia.
12/2012Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells.

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Kevin R Coombes Research Topics

Disease

41Neoplasms (Cancer)
04/2023 - 01/2005
17Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/2019 - 01/2009
12B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2023 - 06/2003
11Leukemia
06/2019 - 01/2009
9Lung Neoplasms (Lung Cancer)
01/2019 - 09/2011
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2018 - 09/2011
5Breast Neoplasms (Breast Cancer)
01/2012 - 11/2004
4Carcinogenesis
11/2012 - 11/2004
4Pancreatic Neoplasms (Pancreatic Cancer)
03/2008 - 02/2005
3Adenocarcinoma of Lung
10/2018 - 07/2014
3B-Cell Lymphoma (Lymphoma, B Cell)
01/2016 - 04/2011
2Sarcoma (Soft Tissue Sarcoma)
02/2015 - 02/2012
2Hypoxia (Hypoxemia)
02/2015 - 07/2014
2Ovarian Epithelial Carcinoma
07/2012 - 09/2011
2Ovarian Neoplasms (Ovarian Cancer)
07/2012 - 05/2010
2Carcinoma (Carcinomatosis)
09/2005 - 01/2005
1T-Cell Leukemia (Leukemia, T Cell)
01/2023
1Oropharyngeal Neoplasms
01/2023
1Virus Diseases (Viral Diseases)
01/2019
1Sialadenitis
11/2016
1Xerostomia
11/2016
1Thyroid Neoplasms (Thyroid Cancer)
11/2016
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2016
1Anorexia
01/2016
1Diarrhea
01/2016
1Agammaglobulinemia (Hypogammaglobulinemia)
01/2016
1Weight Loss (Weight Reduction)
01/2016
1Vomiting
01/2016
1Lymphoma (Lymphomas)
01/2016
1Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2016
1Lethargy
01/2016
1Glioblastoma (Glioblastoma Multiforme)
11/2014

Drug/Important Bio-Agent (IBA)

31Proteins (Proteins, Gene)FDA Link
01/2023 - 11/2004
16Biomarkers (Surrogate Marker)IBA
01/2019 - 01/2005
7MicroRNAs (MicroRNA)IBA
04/2023 - 03/2008
7Messenger RNA (mRNA)IBA
10/2018 - 06/2005
6DNA (Deoxyribonucleic Acid)IBA
01/2023 - 11/2010
4RNA (Ribonucleic Acid)IBA
10/2018 - 01/2002
3Transcription Factors (Transcription Factor)IBA
04/2023 - 08/2015
3Erlotinib Hydrochloride (CP 358,774)FDA Link
10/2016 - 12/2014
3Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA
04/2011 - 06/2003
2Oncogene Proteins (Oncogene Protein)IBA
01/2022 - 01/2019
2ibrutinibIBA
01/2020 - 01/2016
2Small Interfering RNA (siRNA)IBA
06/2018 - 04/2017
2Histones (Histone)IBA
01/2018 - 01/2017
2MethyltransferasesIBA
01/2017 - 12/2012
2Sorafenib (BAY 43-9006)FDA Link
10/2016 - 12/2014
2CateninsIBA
02/2015 - 12/2010
2PlatinumIBA
07/2014 - 07/2012
2taxaneIBA
07/2012 - 07/2011
2inter-alpha-inhibitorIBA
09/2011 - 02/2005
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
11/2010 - 05/2009
2Fluorouracil (Carac)FDA LinkGeneric
06/2010 - 09/2005
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2010 - 04/2009
2PhosphoproteinsIBA
03/2010 - 01/2009
2Serum Amyloid A Protein (Serum Amyloid A)IBA
11/2005 - 02/2005
2Complementary DNA (cDNA)IBA
03/2004 - 01/2002
1Histone DemethylasesIBA
01/2023
1Lysine (L-Lysine)FDA Link
01/2023
1Galectin 3 (LGALS3)IBA
06/2019
1NF-kappa B (NF-kB)IBA
01/2019
1IGF-I-IGFBP-3 complexFDA Link
01/2019
1Notch ReceptorsIBA
01/2019
1TNF Receptor-Associated Factor 3IBA
01/2019
1thiamine triphosphorate (TTP)IBA
01/2019
1InterferonsIBA
01/2019
1Peptide Initiation Factors (Initiation Factor)IBA
06/2018
1Eukaryotic Initiation Factor-2 (EIF 2)IBA
06/2018
1Glutamine (L-Glutamine)FDA Link
01/2018
1Long Noncoding RNAIBA
04/2017
1Proteasome Endopeptidase Complex (Proteasome)IBA
04/2017
1AZD 6244IBA
10/2016
1MK 2206IBA
10/2016
1B7-H1 AntigenIBA
02/2016
1ErbB Receptors (EGF Receptor)IBA
01/2016
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2016
1Gefitinib (Iressa)FDA Link
01/2016
1acalabrutinibIBA
01/2016
1venetoclaxIBA
12/2015
1Mechanistic Target of Rapamycin Complex 1IBA
08/2015
1Caspase 9IBA
02/2015
1IntegrinsIBA
02/2015
1Botulinum Toxins (Botulinum Toxin)IBA
02/2015
1NucleophosminIBA
02/2015
1Fibronectins (Fibronectin)IBA
02/2015
1Hypoxia-Inducible Factor 1IBA
02/2015
1Endoplasmic Reticulum Chaperone BiPIBA
02/2015
1Tyrosine (L-Tyrosine)FDA Link
02/2015
1Protein Phosphatase 2 (Protein Phosphatase 2A)IBA
09/2014
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2014
1cediranib (AZD2171)IBA
07/2014
1Enhancer of Zeste Homolog 2 ProteinIBA
07/2014
1Caspase 8 (Caspase-8)IBA
02/2014
1birinapantIBA
02/2014
1Protein Glutamine gamma Glutamyltransferase 2IBA
07/2013
1SmokeIBA
01/2013
1Cytidine Monophosphate (CMP)IBA
01/2013

Therapy/Procedure

16Therapeutics
01/2020 - 06/2005
6Drug Therapy (Chemotherapy)
04/2017 - 03/2008
1Aftercare (After-Treatment)
01/2019