Jan Cools Selected Research

Platelet-Derived Growth Factor alpha Receptor

4/2004	The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.
1/2004	The FIP1L1-PDGFRalpha kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia.
3/2003	A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.

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Jan Cools Research Topics

Disease

35	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/2024 - 09/2004
32	Neoplasms (Cancer) 01/2023 - 08/2002
29	Leukemia 10/2022 - 05/2003
25	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 10/2022 - 06/2005
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/2022 - 09/2004
9	Hypereosinophilic Syndrome (Loeffler Endocarditis) 08/2007 - 03/2003
8	Pdgfra-Associated Chronic Eosinophilic Leukemia 04/2014 - 01/2004
6	Eosinophilia 05/2014 - 06/2003
4	Lymphoma (Lymphomas) 01/2019 - 06/2011
4	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 05/2014 - 02/2005
4	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 08/2012 - 04/2004
4	Systemic Mastocytosis 01/2008 - 06/2003
2	Infections 01/2024 - 11/2015
2	Neoplasm Metastasis (Metastasis) 01/2023 - 01/2022
2	T-Cell Lymphoma (Lymphoma, T Cell) 12/2022 - 01/2020
2	Splenomegaly 01/2019 - 06/2003
2	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2017 - 08/2002
2	Neuroblastoma 07/2015 - 09/2010
2	B-Cell Lymphoma (Lymphoma, B Cell) 12/2014 - 01/2014
2	Genetic Translocation (Chromosomal Translocation) 01/2014 - 07/2008
2	Disease Progression 01/2014 - 07/2007
2	Renal Cell Carcinoma (Grawitz Tumor) 01/2007 - 08/2006
2	Hematologic Neoplasms (Hematological Malignancy) 05/2006 - 11/2003
1	Malaria 01/2024
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2024
1	Breast Neoplasms (Breast Cancer) 01/2023
1	Lung Neoplasms (Lung Cancer) 01/2023
1	Prostatic Neoplasms (Prostate Cancer) 01/2023
1	Myeloid Leukemia (Leukemia, Myelocytic) 09/2022
1	T-Cell Prolymphocytic Leukemia (Leukemia, T Cell, Chronic) 05/2021
1	T-Cell Leukemia (Leukemia, T Cell) 05/2021
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 05/2021
1	Thymus Hyperplasia 01/2021
1	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 01/2021

Drug/Important Bio-Agent (IBA)

21	Phosphotransferases (Kinase)IBA 11/2021 - 01/2004
20	Imatinib Mesylate (Gleevec)FDA Link 01/2021 - 03/2003
15	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 03/2003
14	Proteins (Proteins, Gene)FDA Link 01/2023 - 05/2003
8	RNA (Ribonucleic Acid)IBA 01/2024 - 01/2013
7	Tyrosine (L-Tyrosine)FDA Link 05/2014 - 11/2005
6	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 05/2014 - 06/2003
5	Transcription Factors (Transcription Factor)IBA 01/2023 - 01/2013
5	tyrosine receptor (receptor, tyrosine)IBA 04/2014 - 04/2006
5	Tyrosine Kinase InhibitorsIBA 08/2012 - 05/2003
4	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 02/2024 - 11/2003
4	Dexamethasone (Maxidex)FDA LinkGeneric 01/2023 - 04/2008
4	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2023 - 04/2008
4	ruxolitinibIBA 12/2021 - 12/2019
4	Interleukin-7 (Interleukin 7)IBA 05/2021 - 05/2011
4	Protein Isoforms (Isoforms)IBA 01/2019 - 04/2006
4	LigandsIBA 01/2019 - 05/2014
4	midostaurinIBA 12/2008 - 02/2005
3	DNA (Deoxyribonucleic Acid)IBA 04/2022 - 08/2014
3	venetoclaxIBA 01/2021 - 12/2014
3	EltanexorIBA 01/2021 - 05/2017
3	Messenger RNA (mRNA)IBA 01/2021 - 12/2016
3	Anaplastic Lymphoma KinaseIBA 01/2017 - 08/2002
3	Protein Tyrosine PhosphatasesIBA 06/2015 - 06/2010
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 05/2012 - 06/2011
3	Sorafenib (BAY 43-9006)FDA Link 09/2008 - 08/2006
3	Platelet-Derived Growth Factor alpha ReceptorIBA 04/2004 - 03/2003
2	Serine (L-Serine)FDA Link 01/2023 - 11/2019
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2023 - 11/2019
2	Histone Deacetylases (Histone Deacetylase)IBA 12/2022 - 10/2019
2	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2022 - 11/2020
2	MRK 560IBA 01/2021 - 01/2019
2	Gamma Secretase Inhibitors and ModulatorsIBA 01/2021 - 04/2008
2	Vincristine (Oncovin)FDA LinkGeneric 11/2020 - 04/2008
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 10/2019 - 01/2007
2	Janus Kinase 3IBA 01/2018 - 11/2015
2	Small Interfering RNA (siRNA)IBA 12/2016 - 05/2008
2	Janus Kinase InhibitorsIBA 11/2015 - 10/2015
2	Cytokine Receptors (Cytokine Receptor)IBA 11/2015 - 11/2014
1	Antimalarials (Antimalarial Agents)IBA 01/2024
1	PalmitatesIBA 01/2023
1	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 01/2023
1	NF-kappa B (NF-kB)IBA 01/2023
1	Etoposide (VP 16)FDA LinkGeneric 01/2023
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 01/2023
1	Sertraline (Zoloft)FDA LinkGeneric 01/2023
1	Lysine AcetyltransferasesIBA 01/2023
1	Histone Deacetylase InhibitorsIBA 12/2022
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 10/2022
1	Lysine (L-Lysine)FDA Link 09/2022
1	Histones (Histone)IBA 09/2022
1	AnthracyclinesIBA 09/2022
1	histone H3 trimethyl Lys4IBA 09/2022
1	NucleotidesIBA 04/2022
1	SteroidsIBA 12/2021
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2021
1	AZD 6244IBA 12/2021
1	AZD1208IBA 01/2021
1	lambda Spi-1IBA 01/2021
1	palbociclibIBA 01/2021
1	dactolisibIBA 01/2021
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2021
1	Tetracycline (Achromycin)FDA LinkGeneric 01/2021

Therapy/Procedure

15	Therapeutics 01/2023 - 11/2003
5	Drug Therapy (Chemotherapy) 01/2023 - 04/2008
1	Transplantation 01/2021