Marcia R Cominetti Selected Research

Cisplatin (Platino)

1/2022	Ruthenium(II)-diphosphine complexes containing acylthiourea ligands are effective against lung and breast cancers.
11/2020	Ru(II)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer.
4/2020	Selective Coordination Mode of Acylthiourea Ligands in Half-Sandwich Ru(II) Complexes and Their Cytotoxic Evaluation.
10/2019	Non-mutagenic Ru(ii) complexes: cytotoxicity, topoisomerase IB inhibition, DNA and HSA binding.
1/2018	Hydrolysis reaction promotes changes in coordination mode of Ru(II)/acylthiourea organometallic complexes with cytotoxicity against human lung tumor cell lines.
11/2017	Selective Ru(II)/lawsone complexes inhibiting tumor cell growth by apoptosis.
3/2016	Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: Cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole.
9/2015	Ru(II)-based complexes with N-(acyl)-N',N'-(disubstituted)thiourea ligands: Synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells.

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Marcia R Cominetti Research Topics

Disease

18	Neoplasms (Cancer) 12/2022 - 08/2009
11	Breast Neoplasms (Breast Cancer) 01/2021 - 08/2009
9	Triple Negative Breast Neoplasms 06/2021 - 09/2017
4	Lung Neoplasms (Lung Cancer) 01/2022 - 09/2015
3	Cognitive Dysfunction 02/2024 - 01/2021
3	Alzheimer Disease (Alzheimer's Disease) 02/2024 - 01/2020
3	Inflammation (Inflammations) 10/2021 - 01/2020
3	Prostatic Neoplasms (Prostate Cancer) 04/2020 - 09/2015
2	Dementia (Dementias) 02/2024 - 01/2020
2	Neoplasm Metastasis (Metastasis) 01/2019 - 09/2017
1	COVID-19 01/2021
1	Retinoblastoma (Glioblastoma, Retinal) 01/2020
1	Frailty 11/2018
1	Ulcer 01/2018
1	Wounds and Injuries (Trauma) 01/2018
1	Thrombosis (Thrombus) 05/2008

Drug/Important Bio-Agent (IBA)

8	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 09/2015
7	RutheniumIBA 12/2022 - 03/2016
6	Biomarkers (Surrogate Marker)IBA 02/2024 - 01/2018
6	gingerolIBA 06/2021 - 01/2017
3	Antineoplastic Agents (Antineoplastics)IBA 01/2019 - 07/2018
2	LigandsIBA 01/2022 - 05/2014
2	Hormones (Hormone)IBA 01/2021 - 09/2020
2	NaphthoquinonesIBA 01/2021 - 11/2020
2	tesmilifene (DPPE)IBA 11/2020 - 01/2019
2	DNA (Deoxyribonucleic Acid)IBA 09/2020 - 10/2017
2	1,10-phenanthrolineIBA 01/2019 - 11/2017
2	bathophenanthrolineIBA 01/2019 - 11/2017
2	2,2'-Dipyridyl (2,2 Bipyridine)IBA 01/2019 - 11/2017
2	CollagenIBA 01/2018 - 08/2009
1	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 12/2022
1	Cytotoxins (Cytolysins)IBA 01/2022
1	hydroxide ionIBA 10/2021
1	25-hydroxyvitamin DIBA 10/2021
1	Gallic AcidIBA 01/2021
1	Interleukin-10 (Interleukin 10)IBA 01/2021
1	CytokinesIBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Diclofenac (SR 38)FDA LinkGeneric 09/2020
1	2,4-dinitrophenylhydrazineIBA 01/2020
1	AcidsIBA 01/2020
1	Amyloid (Amyloid Fibrils)IBA 01/2020
1	Coumaric AcidsIBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	DiaminesIBA 01/2019
1	Estrogens (Estrogen)FDA Link 01/2019
1	ethylenediamine (ethylenediamine dihydroiodide)FDA Link 01/2019
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2019
1	Transferrin Receptors (Transferrin Receptor)IBA 01/2019
1	human ERBB2 proteinIBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2018
1	CaspasesIBA 07/2018
1	Estrogen Receptor alphaIBA 01/2018
1	GlycosaminoglycansIBA 01/2018
1	phytobacteriomycin (PBM)IBA 01/2018
1	triphenylphosphineIBA 11/2017
1	lawsoneIBA 11/2017
1	4,4'-dimethyl-2,2'-bipyridineIBA 11/2017
1	dichlorotetrakis(dimethyl sulfoxide)ruthenium II (trans-Ru)IBA 11/2017
1	Coordination ComplexesIBA 10/2017
1	Caspase 3 (Caspase-3)IBA 09/2017
1	GelsIBA 01/2017
1	ErbB Receptors (EGF Receptor)IBA 01/2017
1	Laminin (Merosin)IBA 01/2017
1	benzonidazole (benznidazole)IBA 03/2016
1	ThiazolidinesIBA 03/2016
1	ThionesIBA 03/2016
1	SugarsIBA 07/2010
1	Integrin beta1IBA 08/2009
1	DisintegrinsIBA 08/2009
1	matrigelIBA 08/2009
1	Integrin beta3 (GPIIIa)IBA 05/2008

Therapy/Procedure

2	Therapeutics 09/2017 - 01/2017
1	Drug Therapy (Chemotherapy) 01/2019
1	Artificial Skin 01/2018