Joanna Cieśla Selected Research

Trichinellosis

10/2017	Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.
9/2005	Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme.

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Joanna Cieśla Research Topics

Disease

5	Neoplasms (Cancer) 02/2023 - 01/2012
2	Leukemia 07/2019 - 08/2018
2	Trichinellosis 10/2017 - 09/2005
2	Leukemia L1210 12/2015 - 01/2006
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/2019
1	Breast Neoplasms (Breast Cancer) 08/2018

Drug/Important Bio-Agent (IBA)

6	Thymidylate SynthaseIBA 02/2023 - 09/2005
6	EnzymesIBA 01/2022 - 01/2006
3	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 02/2023 - 05/2017
3	Casein Kinase II (Casein Kinase 2)IBA 01/2022 - 08/2018
2	Methotrexate (Mexate)FDA LinkGeneric 07/2019 - 05/2017
1	LigandsIBA 10/2017
1	thymidylate synthase-dihydrofolate reductaseIBA 05/2017
1	Fluorouracil (Carac)FDA LinkGeneric 05/2017
1	FluorodeoxyuridylateIBA 12/2015
1	Proteins (Proteins, Gene)FDA Link 12/2015
1	AntibodiesIBA 01/2012
1	Tyrosine (L-Tyrosine)FDA Link 01/2012
1	fexofenadine (Allegra)FDA LinkGeneric 09/2005
1	Messenger RNA (mRNA)IBA 09/2005

Therapy/Procedure

2	Therapeutics 07/2019 - 05/2017
2	Drug Therapy (Chemotherapy) 05/2017 - 02/2015