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Hong Cheng Selected Research

Tamoxifen

1/2021SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models.
1/2020GPER mediates decreased chemosensitivity via regulation of ABCG2 expression and localization in tamoxifen-resistant breast cancer cells.
1/2020Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
5/2015Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells.

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Hong Cheng Research Topics

Disease

142Neoplasms (Cancer)
04/2024 - 11/2002
32Obesity
11/2023 - 06/2007
19Breast Neoplasms (Breast Cancer)
04/2024 - 05/2013
18Hypertension (High Blood Pressure)
12/2023 - 01/2004
18Infections
04/2023 - 07/2004
18Neoplasm Metastasis (Metastasis)
01/2023 - 03/2014
13Insulin Resistance
01/2023 - 01/2004
11Inflammation (Inflammations)
02/2024 - 06/2006
11Hypoxia (Hypoxemia)
01/2023 - 10/2017
10Chronic Renal Insufficiency
01/2024 - 01/2018
9Abdominal Obesity
01/2022 - 06/2007
8Membranous Glomerulonephritis (Membranous Nephropathy)
02/2024 - 01/2016
8Overweight
05/2023 - 06/2007
8Ischemic Stroke
06/2022 - 01/2012
7Proteinuria
02/2024 - 12/2011
7Stroke (Strokes)
01/2024 - 01/2012
7Cardiovascular Diseases (Cardiovascular Disease)
12/2023 - 12/2016
7Dyslipidemias (Dyslipidemia)
12/2023 - 08/2011
6COVID-19
05/2024 - 02/2021
6Type 2 Diabetes Mellitus (MODY)
12/2023 - 01/2021
6Pain (Aches)
12/2023 - 01/2009
6Hypersensitivity (Allergy)
12/2023 - 09/2009
6Hyperglycemia
11/2023 - 01/2017
6Fibrosis (Cirrhosis)
06/2022 - 06/2012
6Glioma (Gliomas)
01/2020 - 06/2010
6Metabolic Syndrome (Dysmetabolic Syndrome X)
11/2013 - 06/2007
5Spinal Cord Injuries (Spinal Cord Injury)
07/2023 - 06/2004
5Starvation
01/2023 - 01/2017
5Necrosis
01/2019 - 03/2006
4Glomerulonephritis
05/2024 - 12/2012
4IGA Glomerulonephritis (IGA Nephropathy)
05/2024 - 02/2021
4Non-alcoholic Fatty Liver Disease
12/2023 - 08/2011
4Neuralgia (Stump Neuralgia)
11/2023 - 11/2014
4Birth Weight (Birth Weights)
11/2023 - 07/2010
4Vitamin D Deficiency
11/2023 - 01/2020
4Hepatocellular Carcinoma (Hepatoma)
05/2023 - 03/2004
4B-Cell Lymphoma (Lymphoma, B Cell)
01/2023 - 12/2018
4Body Weight (Weight, Body)
01/2023 - 01/2015
4Prostatic Neoplasms (Prostate Cancer)
08/2022 - 11/2002
4Ischemia
06/2022 - 10/2005
4Hemorrhage
04/2022 - 01/2019
4Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
01/2022 - 12/2014
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022 - 09/2012
4Carcinogenesis
01/2022 - 02/2007
4Wounds and Injuries (Trauma)
01/2021 - 12/2011

Drug/Important Bio-Agent (IBA)

391-phenyl-3,3-dimethyltriazene (PDT)IBA
04/2024 - 01/2011
30Proteins (Proteins, Gene)FDA Link
02/2024 - 05/2004
25Glucose (Dextrose)FDA LinkGeneric
01/2022 - 06/2007
18DNA (Deoxyribonucleic Acid)IBA
04/2024 - 06/2010
17LipidsIBA
12/2023 - 08/2005
13Reactive Oxygen Species (Oxygen Radicals)IBA
04/2024 - 10/2017
12Therapeutic UsesIBA
02/2024 - 03/2004
12Messenger RNA (mRNA)IBA
02/2022 - 03/2006
11Photosensitizing Agents (Photosensitizers)IBA
04/2024 - 11/2017
11Triglycerides (Triacylglycerol)IBA
11/2023 - 01/2004
11Oxygen (Dioxygen)IBA
01/2023 - 12/2014
9AntigensIBA
01/2024 - 07/2004
9HDL CholesterolIBA
11/2023 - 01/2004
8Peptides (Polypeptides)IBA
04/2024 - 12/2003
8Biomarkers (Surrogate Marker)IBA
11/2023 - 10/2011
7EnzymesIBA
10/2022 - 03/2012
7Immunoglobulin G (IgG)IBA
12/2021 - 09/2012
7AdipokinesIBA
01/2018 - 12/2008
7LeptinIBA
01/2018 - 07/2007
6protoporphyrin IXIBA
04/2024 - 12/2015
6oxidized low density lipoproteinIBA
05/2023 - 12/2008
6CholesterolIBA
01/2022 - 06/2007
6Insulin (Novolin)FDA Link
10/2021 - 12/2008
5RNA (Ribonucleic Acid)IBA
12/2023 - 01/2021
5Vitamin DFDA LinkGeneric
11/2023 - 01/2020
5hydroxide ionIBA
11/2023 - 01/2020
5InflammasomesIBA
05/2023 - 01/2018
5Amoxicillin (Wymox)FDA LinkGeneric
04/2023 - 08/2012
5Caspase 3 (Caspase-3)IBA
02/2022 - 05/2004
5CateninsIBA
01/2022 - 01/2015
5LDL CholesterolIBA
01/2022 - 12/2008
5AcidsIBA
01/2022 - 03/2012
5Blood Glucose (Blood Sugar)IBA
01/2020 - 04/2008
5Antihypertensive Agents (Antihypertensives)IBA
08/2018 - 01/2004
4Complement System Proteins (Complement)IBA
05/2024 - 01/2012
4CytokinesIBA
04/2023 - 01/2014
4AntioxidantsIBA
01/2023 - 10/2005
4Adenosine Triphosphate (ATP)IBA
06/2022 - 11/2013
4MicroRNAs (MicroRNA)IBA
01/2022 - 12/2018
4Doxorubicin (Adriamycin)FDA LinkGeneric
01/2022 - 07/2015
4Circular RNAIBA
01/2022 - 01/2021
4MetalsIBA
10/2021 - 09/2009
4Phospholipids (Phosphatides)FDA LinkGeneric
03/2021 - 08/2017
4CreatinineIBA
01/2021 - 12/2011
4Estrogen ReceptorsIBA
01/2021 - 05/2015
4TamoxifenFDA LinkGeneric
01/2021 - 05/2015
4Phosphotransferases (Kinase)IBA
01/2019 - 10/2013
4ProdrugsIBA
01/2019 - 10/2014
4AdiponectinIBA
01/2018 - 02/2011

Therapy/Procedure

91Therapeutics
04/2024 - 10/2009
34Photochemotherapy (Photodynamic Therapy)
04/2024 - 01/2011
23Drug Therapy (Chemotherapy)
09/2023 - 09/2009
14Immunotherapy
04/2024 - 10/2017
9Precision Medicine
01/2022 - 10/2016
5Chinese Traditional Medicine (Traditional Chinese Medicine)
01/2023 - 06/2017